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Method for creating multi-index quantitative fingerprint spectrum for food retention-removing and cough-relieving oral solution for children

A technology for eliminating accumulation and relieving cough and fingerprinting in children, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of lack of overall quality of preparations, control research, etc., and achieve the solution of chromatographic peak tailing, high detection accuracy and stability Good results

Active Publication Date: 2017-11-03
SHANDONG ANALYSIS & TEST CENT
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Problems solved by technology

However, the above studies mainly determined the contents of several main active ingredients, and there was a lack of research on the overall quality control of the preparation.

Method used

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  • Method for creating multi-index quantitative fingerprint spectrum for food retention-removing and cough-relieving oral solution for children
  • Method for creating multi-index quantitative fingerprint spectrum for food retention-removing and cough-relieving oral solution for children
  • Method for creating multi-index quantitative fingerprint spectrum for food retention-removing and cough-relieving oral solution for children

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Embodiment Construction

[0031] It should be pointed out that the following detailed description is exemplary and intended to provide further explanation to the present application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0032] It should be noted that the terminology used here is only for describing specific implementations, and is not intended to limit the exemplary implementations according to the present application. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations, means, components and / or combinations thereof.

[0033] 1. Instruments and materials

[0034] Maple S6000 high performance liquid chromatography; Agilent 6520Q-TO...

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Abstract

The invention discloses a method for creating a multi-index quantitative fingerprint spectrum for food retention-removing and cough-relieving oral solution for children, which includes the following steps: high-performance liquid chromatography (HPLC)-diode array detector-electrospray ionization-quadrupole-time of flight mass spectrometry combination is adopted to detect chemical information characteristic peaks of a variety of common chemical substances in multiple batches of food retention-removing and cough-relieving oral solution for children, and according to the detected chromatographic peaks of a variety of the common chemical substances in the multiple batches of retention-removing and cough-relieving oral solution for children in combination with multi-index ingredient content determination, a fingerprint spectrum of the food retention-removing and cough-relieving oral solution for children is created. The method adopts the HPLC-DAD-ESI-Q-TOF / MS technique to analyze and identify chemical ingredients in the food retention-removing and cough-relieving oral solution for children, quality control indexes are chosen in reference to the principle of concerted application of Chinese herbal medicines and by referring to individual herb quality control indexes in one volume of 2015 edition of Chinese Pharmacopoeia and an identification result of each common peak, an HPLC multi-index quantitative fingerprint spectrum is created on the basis, and thereby a relatively comprehensive method and technical support are provided for the research on the evaluation of the overall quality of the food retention-removing and cough-relieving oral solution for children.

Description

technical field [0001] The invention relates to the analysis, identification, content determination and quality control of chemical components in Xiaoer Xiaoji Zhike Oral Liquid, in particular to a method for establishing a multi-index quantitative fingerprint of Xiaoer Xiaoji Zhike Oral Liquid. Background technique [0002] Xiaoer Xiaoji Zhike Oral Liquid is a compound preparation composed of ten kinds of Chinese medicinal materials such as hawthorn, betel nut, citrus aurantium, loquat leaf, melon, radish seed, Tinglizi, bellflower, forsythia, and cicada slough. It has a very obvious curative effect on children with food accumulation cough. The 2015 edition of "Chinese Pharmacopoeia" stipulates that the HPLC method is used to determine the content of synephrine for the quality control of Xiaoer Xiaoji Zhike Oral Liquid. However, the chemical composition of this preparation is extremely complex, and the determination of the content of a single component cannot fully reflect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88G01N30/34
CPCG01N30/34G01N30/88G01N2030/884
Inventor 赵恒强王晓王涛耿岩玲闫慧娇刘伟
Owner SHANDONG ANALYSIS & TEST CENT
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