Unlock instant, AI-driven research and patent intelligence for your innovation.

Ferric-oxide nano material and application thereof used as tumor-drug targeting carriers

A technology of iron oxide nanometer and ferric chloride, which is applied in the field of biomaterials, can solve the problem that drugs cannot be delivered specifically to tumor cells, and achieve high safety effects

Active Publication Date: 2017-11-07
HAIMEN BIWEI INTPROP SERVICE CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, although the existing targeting vectors are targeted to tumor cells, they are not selective to different tumor cells, which leads to the lack of specificity of drugs when performing targeted therapy on patients suffering from multiple cancers at the same time. delivery to specific types of tumor cells, while some drug active ingredients only have inhibitory or killing effects on specific tumor cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ferric-oxide nano material and application thereof used as tumor-drug targeting carriers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of Iron Oxide Nanomaterials

[0021] Prepared by the following method:

[0022] First dissolve ferric chloride hexahydrate, polyvinylpyrrolidone and bis-(3-methyl-1-imidazole) butylene bisulphate in distilled water, then transfer to a reactor with a polytetrafluoroethylene liner for hydrothermal Reaction, the reaction temperature is 200°C, the reaction time is 20h, and finally centrifuged, washed, dried, calcined, and ground; wherein, the molar concentration of ferric chloride hexahydrate is 0.035mol / L, and the concentration of polyvinylpyrrolidone is 10g / L. The molar concentration of bis-(3-methyl-1-imidazole) butylene bissulfate is 0.015mol / L.

[0023] Among them, washing with ethanol and deionized water alternately 4 times, each washing volume is 10 times the weight of the precipitate; the temperature during drying is 70°C, and the drying time is 10h; the calcination temperature is 500°C, and the calcination time is 4h.

[0024] figure 1 It i...

Embodiment 2

[0025] Example 2 Preparation of Iron Oxide Nanomaterials

[0026] Prepared by the following method:

[0027] First dissolve ferric chloride hexahydrate, polyvinylpyrrolidone and bis-(3-methyl-1-imidazole) butylene bisulphate in distilled water, then transfer to a reactor with a polytetrafluoroethylene liner for hydrothermal Reaction, the reaction temperature is 180°C, the reaction time is 22h, and finally centrifuged, washed, dried, calcined, and ground; wherein, the molar concentration of ferric chloride hexahydrate is 0.03mol / L, and the concentration of polyvinylpyrrolidone is 8g / L. The molar concentration of bis-(3-methyl-1-imidazole) butylene bisulphate is 0.01 mol / L.

[0028] Among them, washing with ethanol and deionized water alternately for 3 times, each washing volume is 15 times the weight of the precipitate; the temperature during drying is 60°C, and the drying time is 12h; the calcination temperature is 450°C, and the calcination time is 5h.

[0029] The TEM tran...

Embodiment 3

[0030] Example 3 Preparation of Iron Oxide Nanomaterials

[0031] Prepared by the following method:

[0032] First dissolve ferric chloride hexahydrate, polyvinylpyrrolidone and bis-(3-methyl-1-imidazole) butylene bisulphate in distilled water, then transfer to a reactor with a polytetrafluoroethylene liner for hydrothermal Reaction, the reaction temperature is 220°C, the reaction time is 18h, and finally centrifuged, washed, dried, calcined, and ground; wherein, the molar concentration of ferric chloride hexahydrate is 0.04mol / L, and the concentration of polyvinylpyrrolidone is 12g / L. The molar concentration of bis-(3-methyl-1-imidazole) butylene bissulfate is 0.02 mol / L.

[0033] Among them, washing with ethanol and deionized water alternately 5 times, each washing volume is 5 times the weight of the precipitate; the temperature during drying is 80°C, and the drying time is 8h; the calcination temperature is 550°C, and the calcination time is 3h.

[0034] The TEM transmiss...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a ferric-oxide nano material and an application thereof used as tumor-drug targeting carriers. The ferric-oxide nano material is prepared by the following method including the steps of: firstly dissolving ferric chloride, polyvinylpyrrolidone and bi-(3-methyl-1-imidazole) butylidene bihydrosulfate in distilled water, then carrying out hydrothermal reaction with the reaction temperature of 180-220 DEG C and the reaction time of 18-22 hours, and finally centrifuging, washing, drying, calcining and grinding, wherein the molar concentration of the ferric chloride is 0.03-0.04mol / L, the concentration of the polyvinylpyrrolidone is 8-12g / L, and the molar concentration of the bi-(3-methyl-1-imidazole) butylidene bihydrosulfate is 0.01-0.02mol / L. The ferric-oxide nano material provided by the invention has specific affinity for leukemia tumor cells, has no obvious affinity action for tumor cells of stomach cancer and lung cancer and the like, can be used as drug carriers of specific targeting leukemia tumor cells, has no obvious cytotoxicity for normal cells and is high in safety.

Description

technical field [0001] The invention belongs to the field of biological materials and relates to a drug carrier and its preparation, in particular to an iron oxide nano material and its use as a tumor drug targeting carrier. Background technique [0002] Anticancer drugs have almost no selectivity for tumor tissues and normal cells, and generally have problems such as low curative effect, high toxicity, difficult to control metastases, and poor drug compliance of patients. Therefore, the antitumor drug delivery system has become the research focus and hotspot in the field of pharmacy. Among them, the targeted delivery system has been proven to effectively reduce the adverse reactions of anti-tumor drugs, improve clinical efficacy and drug compliance of patients. [0003] The nano drug carrier system is the product of the combination of nano and modern medicine. It is a nano-scale drug carrier delivery system. Compared with traditional small molecule drugs, it is easier to b...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C01G49/06B82Y40/00A61K47/02A61P35/02
CPCA61K47/02C01G49/06C01P2004/04C01P2004/64
Inventor 王严付玉樊星
Owner HAIMEN BIWEI INTPROP SERVICE CO LTD