Choline phosphate modified acne treatment cream and preparation method thereof

A technology of phosphorylcholine and acne-removing cream, which is applied in the field of phosphorylcholine-modified acne-removing cream and its preparation, and can solve problems such as skin allergies, single therapeutic effect, and poor therapeutic effect

Inactive Publication Date: 2017-11-10
WUHU FOMAN BIOPHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, most of the cosmetics for treating acne currently on the market contain chemical components such as mercury and fruit acids, which are likely to cause adverse reactions such as skin allergies, damage the skin tissue structure, and have unsatisfactory therapeutic effects. Although the few Chinese herbal cosmetics are non-toxic and non-toxic Sti

Method used

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  • Choline phosphate modified acne treatment cream and preparation method thereof
  • Choline phosphate modified acne treatment cream and preparation method thereof

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preparation example Construction

[0016] The invention provides a preparation method of phosphorylcholine modified acne cream, comprising:

[0017] 1) crushing the Chinese herbal medicine, then decocting it in ethanol, then filtering the filtrate, and finally distilling the filtrate to remove the ethanol to obtain the Chinese herbal medicine essence;

[0018] 2) heating glyceryl monostearate, stearyl alcohol, glycerin and herbal essence to form an oil phase;

[0019] 3) heating propylene glycol, phosphorylcholine, triethanolamine, alkyl glucoside and water to form an aqueous phase;

[0020] 4) adding the water phase to the oil phase and stirring, then cooling, and then adding Ligustilide, Saikosaponin, and Abietin acid and stirring to obtain an acne cream;

[0021] Among them, the Chinese herbal medicine consists of white silkworm, white peony root, curcuma, trigonum, comfrey and Burnet.

[0022] In step 1) of the above-mentioned preparation method, the consumption of each material can be selected in a wide ...

Embodiment 1

[0035] 1) Chinese herbal medicines (white silkworm, white peony root, curcuma, trigonum, comfrey and Burnet in a weight ratio of 100:28:45:90:70:50) were crushed to an average particle size of 6 μm, and then placed in 130 decoct in ethanol (the weight ratio of Chinese herbal medicine and ethanol is 100:400) at ℃ for 3 hours, then filter the filtrate, and finally spin the filtrate to remove ethanol to obtain the Chinese herbal medicine essence;

[0036] 2) Heating glyceryl monostearate, stearyl alcohol, glycerin and herbal essence according to the weight ratio of 100:24:33:24 at 85°C for 1.8h to form an oil phase;

[0037] 3) Propylene glycol, phosphorylcholine, triethanolamine, alkyl glucoside and water were heated at 85°C for 1.8 hours at a weight ratio of 100:4:8:16:45 to form a water phase;

[0038] 4) Add the water phase to the oil phase and stir, then naturally cool to 20°C, then add ligustonin, saikosaponin, abietine acid (water phase, oil phase, ligustonin, saikosaponin...

Embodiment 2

[0040] 1) Chinese herbal medicines (white silkworm, white peony root, curcuma, three-lens, comfrey and Burnet in a weight ratio of 100:22:40:80:60:45) were crushed to an average particle size of 3 μm, and then placed in 120 decoct in ethanol (the weight ratio of Chinese herbal medicine and ethanol is 100:300) at ℃ for 2 hours, then filter the filtrate, and finally spin the filtrate to remove ethanol to obtain the Chinese herbal medicine essence;

[0041] 2) Heating glyceryl monostearate, stearyl alcohol, glycerin and herbal essence according to the weight ratio of 100:21:30:22 at 80°C for 1.5h to form an oil phase;

[0042] 3) Propylene glycol, phosphorylcholine, triethanolamine, alkyl glucoside and water were heated at 80°C for 1.5 hours at a weight ratio of 100:3:6:12:40 to form a water phase;

[0043]4) Add the water phase to the oil phase and stir, then naturally cool to 15°C, then add ligustonin, saikosaponin, abietine acid (water phase, oil phase, ligustonin, saikosaponi...

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Abstract

The invention discloses a choline phosphate modified acne treatment cream and a preparation method thereof. The preparation method comprises the steps that 1, Chinese herbal medicine is crushed, then put in ethyl alcohol for decoction and filtered to obtain a filtrate, finally the filtrate is distilled to remove ethyl alcohol, and Chinese herbal medicine essence is prepared; 2, glycerin monostearate, stearyl alcohol, glycerinum and the herbal essence are heated to form an oil phase; 3, propylene glycol, choline phosphate, triethanolamine, alkyl glycoside and water are heated to form a water phase; 4, the water phase is added to the oil phase and stirred, cooled, then added with ligusticum wallichii, bupleurum chinense, abietinic acid, and after mixing, the acne treatment cream is prepared; the Chinese herbal medicine is composed of silkworm larva, radix paeoniae alba, curcuma phaeocaulis, rhizoma sparganii, lithospermum and radix sanguisorbae. The choline phosphate modified acne treatment cream has excellent acne-removing effect and stability, and the preparation method has the advantages of simple process and easy availability of raw materials.

Description

technical field [0001] The invention relates to an acne-removing cream, in particular to a phosphorylcholine-modified acne-removing cream and a preparation method thereof. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous glands, mostly on the face, chest, and back. It is more common in adolescents, and the main forms of onset are acne and acne. Acne has a variety of skin damage forms, including comedones, papules, pustules, nodules, etc. Therefore, acne has always been a common and frequently-occurring disease in dermatology. The cause of disease of acne is comparatively complicated, and modern medicine thinks that the pathogenesis of acne is mainly closely related to factors such as excessive sebum secretion, pilosebaceous duct blockage, bacterial infection and inflammatory response. After entering puberty, the content of androgen in the human body, especially testosterone, increases rapidly, which promotes the development of s...

Claims

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Application Information

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IPC IPC(8): A61K8/98A61K8/9794A61K8/9789A61K8/63A61K8/41A61K8/60A61K8/55A61K8/37A61K8/36A61K8/34A61Q19/00A61P17/10
CPCA61K8/97A61K8/342A61K8/345A61K8/36A61K8/37A61K8/375A61K8/41A61K8/55A61K8/602A61K8/63A61K8/987A61Q19/00
Inventor 苏福男
Owner WUHU FOMAN BIOPHARMA CO LTD
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