Long-acting antibacterial hydrogel and preparation method thereof

An antibacterial water and hydrogel technology, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of inconvenient use and short duration of drug efficacy, and achieve the effect of avoiding the weakening of efficacy and avoiding biological toxicity.

Active Publication Date: 2017-11-10
HENAN HUIBO MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the dressing prepared in this traditional way can also exert the antibacterial and healing effects of the functional ingredients, the drug ingredients are released completely and directly at one time, and the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The long-acting antibacterial hydrogel of this embodiment is prepared by the following method:

[0033] 1) Preparation of microcapsules:

[0034] A: Prepare the aqueous phase:

[0035] Prepare the mass concentration of 2% sodium alginate aqueous solution, add organic silicon quaternary ammonium salt and chitosan oligosaccharide in the sodium alginate aqueous solution, the mass concentration of organic silicon quaternary ammonium salt is 3%; the mass concentration of chitosan oligosaccharide is 3.5% dissolve After mixing evenly, the mixed solution 1 was obtained as the water phase;

[0036] B: Prepare the oil phase:

[0037] Take liquid paraffin, add it to the liquid paraffin according to the mass ratio of Tween 80:span80=1:1.5, so that the mass percentage of Tween 80 and span80 is 3.5%, mix evenly, and use it as the oil phase;

[0038] C: Preparation of cross-linking agent:

[0039] Prepare the chitosan acetic acid solution whose volume concentration is 1.5%, add ca...

Embodiment 2

[0045] The long-acting antibacterial hydrogel of this embodiment is prepared by the following method:

[0046] 1) Preparation of microcapsules:

[0047] A: Prepare the aqueous phase:

[0048] Prepare a mass concentration of 1.5% sodium alginate aqueous solution, add organic silicon quaternary ammonium salt and chitosan oligosaccharide in the sodium alginate aqueous solution, the mass concentration of organic silicon quaternary ammonium salt is 2%; the mass concentration of chitosan oligosaccharide is 2% to dissolve After mixing evenly, the mixed solution 1 was obtained as the water phase;

[0049] B: Prepare the oil phase:

[0050] Take liquid paraffin, add it to the liquid paraffin according to the mass ratio of Tween 80:span80=1:1, so that the mass percentage of Tween 80 and span80 is 2%, mix evenly, and use it as the oil phase;

[0051] C: Preparation of cross-linking agent:

[0052] Prepare the chitosan acetic acid solution whose volume concentration is 1%, add calcium...

Embodiment 3

[0058] The long-acting antibacterial hydrogel of this embodiment is prepared by the following method:

[0059] 1) Preparation of microcapsules:

[0060] A: Prepare the aqueous phase:

[0061] Prepare a mass concentration of 2.5% sodium alginate aqueous solution, add organic silicon quaternary ammonium salt and chitosan oligosaccharide in the sodium alginate aqueous solution, the mass concentration of organic silicon quaternary ammonium salt is 5%; the mass concentration of chitosan oligosaccharide is 5% to dissolve After mixing evenly, the mixed solution 1 was obtained as the water phase;

[0062] B: Prepare the oil phase:

[0063] Take liquid paraffin, add it to the liquid paraffin according to the mass ratio of Tween 80:span80=1:2, so that the mass percentage of Tween 80 and span80 is 5%, mix evenly, and use it as the oil phase;

[0064] C: Preparation of cross-linking agent:

[0065] Prepare the chitosan acetic acid solution whose volume concentration is 2%, add calcium c...

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PUM

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Abstract

The invention relates to the technical field of medical functional dressings, in particular to long-acting antibacterial hydrogel and a preparation method thereof. The hydrogel is characterized in that hydrogel dressing is formed through adding medicine ingredients into a sodium alginate solution to be taken as water phases jointly, wrapping the medicine ingredients in a microcapsule and then adding the microcapsule into a gel substrate; a wound surface is coated with the dressing during the use; under the action of wound surface exudates and body temperature, the microcapsule gradually swells to release the medicine ingredients, so that the controllability of medicine ingredient release is realized, a slow-release effect is realized, medicines can continuously act on a wound in a long-acting way, and the defects that the medicine ingredients cannot continuously realize a medicine effect as traditional dressing directly and completely releases the medicines, and the dressing is required to be constantly replaced are overcome. Chitosan oligosaccharide plays a good role in promoting wound healing, and organosilicon quaternary ammonium salt plays an antibacterial role. Meanwhile, in the long-acting antibacterial hydrogel, the combination of the chitosan oligosaccharide, sodium alginate and calcium chloride is adopted for cross-linking to from the microcapsule, so that the biological toxicity of a chemical cross-linking agent is avoided.

Description

technical field [0001] The invention relates to the technical field of medical functional dressings, in particular to a long-acting antibacterial hydrogel and a preparation method thereof. Background technique [0002] Dressings are essential materials for bandaging and treating wounds or wounds. Medical dressing refers to a type of medical treatment that covers the wound and temporarily replaces the damaged skin protection tissue during the continuous recovery of the wound. As a barrier, it prevents the wound from being polluted by the external environment and provides an excellent healing and rehabilitation environment. supplies. In order to promote wound healing, it is usually necessary to add some functional ingredients to the dressing, such as antibacterial ingredients, healing-promoting ingredients, hemostatic ingredients, and the like. However, the functional components in traditional dressings are usually directly used as one of the raw materials of dressings in th...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0066A61L26/008A61L2300/208A61L2300/232A61L2300/404A61L2300/602A61L2300/622A61L2400/04C08L29/04
Inventor 李延浩周新钦彭克林
Owner HENAN HUIBO MEDICAL CO LTD
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