Method for preparing medical multi-layer placental tissue implant

A placental tissue and production method technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of poor toughness, easy tearing, low immunogenicity, etc., and achieve strong toughness, not easy to tear, and good adhesion effect of effect

Inactive Publication Date: 2017-11-10
江西瑞诺健医学科技有限公司
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  • Abstract
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Problems solved by technology

In order to minimize the immunogenicity of the amnion in the current domestic bio-amnion treatment methods, various chemical reagents are used to decellularize the amnion. Destroying the composition and structure of the amniotic membrane, resulting in too poor toughness to meet clinical needs
The bio-amnion product developed by CN106540323A has been greatly improved in these two aspects, but although the toughness is enhanced, it is still thin and easy to tear

Method used

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Examples

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Embodiment

[0035] A method for making a medical multilayered placental tissue implant, comprising the following steps:

[0036] 1. Obtain placental tissue materials: Placental tissue is obtained from i) full-term, healthy, and qualified cesarean delivery; or ii) full-term, healthy, conventional vaginal delivery. Birth mothers who donate placental tissue must be medically and socially screened and eligible, and routine infectious disease testing of blood and tissue samples at delivery must also meet criteria. The acquisition, packaging and transportation of the tissue must be carried out strictly according to the written plan, so as to preserve the original characteristics of the placental tissue to the greatest extent.

[0037] 2. Isolate amnion and chorionic tissue from placental tissue material: the placental tissue obtained is sent to a controlled treatment environment under aseptic conditions and soaked in a 0.9-3.0wt% sodium chloride aqueous solution (as a rinse solution) Rinse in ...

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PUM

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Abstract

The invention discloses a method for preparing a medical multilayer placental tissue implant. The method for preparing the medical multilayer placental tissue implant comprises the following steps of obtaining a qualified placental tissue material, separating amnion and chorionic tissue from the placental tissue material, treating the amnion and the chorionic tissue, removing blood, cells and DNA, disinfecting decellularized tissue, conducting lamination drying, cutting, and completing preparation. The medical multilayer placental tissue implant has a better adhesion effect on deep wounds, and is strong in toughness and not easy to tear.

Description

technical field [0001] The invention relates to the technical field of medical device dressings, in particular to a method for making a medical multilayer placenta tissue implant. Background technique [0002] Amniotic membrane is a kind of natural excellent biological material, the normal amniotic membrane is thin and transparent, without blood vessel and nerve growth. Clinically, it can be used as a basement membrane to promote epithelial formation, promote epithelial cell migration and differentiation, enhance basal epithelial cell adhesion, prevent epithelial cell apoptosis, and promote epithelial proliferation and differentiation; it can inhibit inflammation and new blood vessels; it can inhibit fibrosis, To achieve the effect of anti-scarring, it can also inhibit the differentiation of myofibroblasts induced by epithelial cells and reduce scar formation; it can be used as a good scaffold for cell migration and growth, and it is used for tissue engineering reconstructio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36
CPCA61L27/3604A61L27/3691A61L2430/40
Inventor 雷良伟
Owner 江西瑞诺健医学科技有限公司
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