CaCO3-(PLO/Fucoidan)<4> self-assembly carriers and preparation method

A technology of polyornithine and fucoidan, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of low drug loading of calcium carbonate microspheres No biological activity and other problems, to achieve the effect of ensuring non-toxic and harmless, improving long-term release and slowing down the release rate

Inactive Publication Date: 2017-11-24
HUAQIAO UNIVERSITY
View PDF7 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of strong reaction, complex operation, no biological activity of modifiers and low drug loading of calcium carbonate microspheres faced by many surface modification technologie...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • CaCO3-(PLO/Fucoidan)&lt;4&gt; self-assembly carriers and preparation method
  • CaCO3-(PLO/Fucoidan)&lt;4&gt; self-assembly carriers and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] In order to further explain the technical solution of the present invention, the present invention will be described in detail below through specific examples.

[0021] 1. Preparation of Self-Assembled Carriers

[0022] a CaCO 3 -(PLO / Fucoidan) 4 Self-assembled carrier, the self-assembled carrier is a LbL microsphere with a core-shell structure formed by polyelectrolyte layer-by-layer assembly on the surface of calcium carbonate microspheres, wherein the polyelectrolyte is composed of polycationic polyornithine (PLO) and polyanionic fucoidin Glycan (Fucoidan) composition.

[0023] a CaCO 3 -(PLO / Fucoidan) 4 The preparation method of self-assembly carrier comprises the following steps:

[0024] (1) Configuration of each solution: use ultrapure water to configure 0.5mol / L sodium carbonate solution and 0.5mol / L calcium chloride solution, configure 0.1mg / mL polyornithine solution and 0.1mg / mL rock The alginate solution, the pH of the polyornithine solution was adjuste...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses CaCO3-(PLO/Fucoidan)<4> self-assembly carriers and a preparation method. CaCO3 microspheres with good biocompatibility are prepared through a coprecipitation method firstly, and growth of the CaCO3 microspheres is controlled by utilizing carboxymethyl chitosan; and polyelectrolytes of PLO and Fucoidan are assembled on the surfaces of the CaCO3 microspheres layer by layer, wherein the polyelectrolytes have nutrient and pharmacological efficacies and are degradable, and thus LbL microspheres, namely the CaCO3-(PLO/Fucoidan)<4> self-assembly carriers, are prepared. According to the preparation method, the coprecipitation method and an LbL technique are combined, the technology is simple, operation is convenient, a complex instrument and equipment are not needed, and the problems of poor biocompatibility of carriers, initial burst release in drug release and the like are solved. The LbL microspheres are of core-shell type structures, can enhance the adsorbing capacity of a drug, reduces the toxic and side effects caused by pure use of the drug and can obviously slow down the release rate of the drug.

Description

technical field [0001] The present invention relates to a calcium carbonate-(polyornithine / fucoidan) 4 Self-assembling carrier and its preparation method. Background technique [0002] With the in-depth study of drug carrier systems and the continuous development of surface modification technology, surface-modified drug carrier systems have become the focus of research in recent years. In the treatment of diseases, the drug carrier entering the animal body may be unable to exert its effect due to the deposition of the adsorbed protein or the phagocytosis of the immune cells. Therefore, the stability of the drug carrier in the animal body is very important for the drug effect. Using surface modification technology Putting an "invisibility cloak" on the surface of the drug carrier can solve this problem to some extent. Therefore, the use of surface modification technology to protect the drug carrier system to achieve safe drug delivery and sustained release therapy can reduc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/16A61K47/36A61K47/34A61K47/02A61K31/785A61K31/715
CPCA61K9/1676A61K9/1682A61K31/715A61K31/785A61K47/02A61K47/34A61K47/36A61K2300/00
Inventor 刘源岗王士斌王沛范静骞
Owner HUAQIAO UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap