Purification and preparation method of morphine base, morphine hydrochloride, heroin hydrochloride standard substance for forensic drug detection

The technology of heroin hydrochloride and heroin hydrochloride is applied in the field of preparation of forensic drug standard products, and can solve the problems of toxicity and easy deterioration when exposed to light, and achieve the effects of ensuring validity, improving accuracy, and effective mutual recognition.

Active Publication Date: 2020-07-28
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Toxic, perishable when exposed to light

Method used

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  • Purification and preparation method of morphine base, morphine hydrochloride, heroin hydrochloride standard substance for forensic drug detection
  • Purification and preparation method of morphine base, morphine hydrochloride, heroin hydrochloride standard substance for forensic drug detection
  • Purification and preparation method of morphine base, morphine hydrochloride, heroin hydrochloride standard substance for forensic drug detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] In this example, the remaining heroin samples after case identification were used to optimize and screen the experimental conditions for separation and purification of heroin by preparative liquid chromatography.

[0041] 1. Instruments, reagents and materials

[0042] 1.1 Main Instruments

[0043] Analytical high-performance liquid chromatography (Shimadzu, Japan), including: LC-20AD high-pressure infusion pump; SIL-10A automatic sampler; SPD-20A diode array detector; CTO-20A column thermostat.

[0044] Preparative high-performance liquid chromatography (Shimadzu, Japan), including: LC-8A high-pressure infusion pump; SIL-10AP autosampler; SPD-M20A diode array detector; FRC-10A automatic fraction collector; CBM-20A system controller.

[0045] BUCHI rotary evaporator (Japan BUCHI company); KQ3200 ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); Feige brand TDL-40B desktop centrifuge (Shanghai Anting Scientific Instrument Factory); XS105 Dual Range electron...

Embodiment 2

[0109] This embodiment mainly hydrolyzes the remaining heroin samples after case identification, using preparative high-performance liquid chromatography, using methanol-0.05% trifluoroacetic acid aqueous mobile phase system or methanol-0.5% acetic acid aqueous mobile phase system to hydrolyze heroin The morphine was separated from the liquid, and further processed to obtain morphine hydrochloride and morphine. The experimental conditions for the preparation of morphine by separation and purification by preparative liquid chromatography were optimized and screened.

[0110] 1. Instruments, reagents and materials

[0111] 1.1 Main Instruments

[0112] Analytical high-performance liquid chromatography (Shimadzu, Japan), including: LC-20AD high-pressure infusion pump; SIL-10A automatic sampler; SPD-20A diode array detector; CTO-20A column thermostat.

[0113] Preparative high-performance liquid chromatography (Agilent), including: G1361A high-pressure infusion pump; G2260A autom...

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Abstract

The invention discloses a purification preparation method of morphine alkaloid, morphine hydrochloride and a heroin hydrochloride standard substance for forensic science drug detection. The purification preparation method comprises: (1) detecting the purity of heroin hydrochloride in seized heroin samples, and selecting the seized heroin samples having a heroin hydrochloride content of more than or equal to 60 wt% as a raw material for purification preparation of morphine alkaloid, morphine hydrochloride and a heroin hydrochloride standard substance; and (2) preparing the morphine alkaloid, the morphine hydrochloride and the heroin hydrochloride standard substance by using high performance liquid chromatography. According to the present invention, the obtained morphine alkaloid, the obtained morphine hydrochloride and the obtained heroin hydrochloride standard substance are analyzed and confirmed by nuclear magnetic resonance, liquid chromatography-tandem mass spectrometry and infrared spectroscopy, the definite values of the purifies are determined by liquid chromatography and gas chromatography, and the impurities unresponsive to chromatography are determined; and according to the standard substance development requirements, the evaluation of the stability, the uniformity, the definite value and the total uncertainty meets the relevant provisions, and the desired indicators are met.

Description

technical field [0001] The invention relates to the preparation of forensic science drug standard products. More specifically, it relates to a method for purifying and preparing standard substances of morphine base, morphine hydrochloride and heroin hydrochloride for forensic drug detection. Background technique [0002] At present, the increasingly serious drug problem has become a global disaster. The proliferation of drugs directly endangers people's physical and mental health, and poses a huge threat to economic development and social progress. Therefore, establishing a forensic scientific drug detection quantity traceability system, improving the measurement technology of drug components, ensuring the reliability and comparability of measurement results, establishing the sharing and mutual recognition of measurement data, and providing accurate and reliable evidence for courts has become a national standard in the world. A general concern of drug identification agenci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D489/04C07D489/02
CPCC07D489/02C07D489/04
Inventor 郑珲高利生杨虹贤赵彦彪张春水赵阳常颖贺剑锋翟晚枫李彭郑晓雨刘克林钱振华
Owner INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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