An anti-adhesion composition for tissue repair film coating and its application method

Abstract

The invention discloses an anti-adhesion composition for coating of a tissue repair film, and a use method of the anti-adhesion composition. The anti-adhesion composition comprises components in parts by weight as follows: 30-60 parts of sodium alginate, 10-20 parts of filling macromolecules, and 10-40 parts of oligomerized anions. At the initial period, the composition provides a good anti-adhesion character, but after 1-2 weeks, the anti-adhesion function is gradually lost. When being used for certain clinical operation materials, the composition provided by the invention can enable a biological tissue repair film and tissue to slowly fuse, so that the interreaction of the repair film and the tissue is buffered, the concentration accumulation of antigens possibly casing immunoreaction is reduced, and the tolerance of the tissue to a heterologous biological material is improved. Application provided by the invention can reduce the difficulty in a clinical operation, a second operation and subsequent nursing and treatment are reduced, and requirements for special materials are met.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and specifically relates to an anti-adhesion composition for coating tissue repair membranes and a method of use thereof. Background technique [0002] After the local tissue is damaged or died due to some pathogenic factors, it will be repaired by the regeneration of neighboring healthy cells to restore the integrity of the tissue. The speed and integrity of the process are affected by many factors. In addition to the type of damaged tissue, these factors include injury-causing factors, nutrition, blood supply, infection, and tissue defects. The tissue repair of the organism itself generally includes blood coagulation, inflammation, and repair period. The blood clotting period is completed within a few minutes, the inflammation period may last 2-7 days, and the repair period lasts for several weeks or even longer. In some severe cases, complete The tissue repair will even exceed 1 year, and the l...

AI Technical Summary

Problems solved by technology

However, when coating a high-concentration sol on the surface of the material and setting the shape, due to the large number of initial crosslinking points and sufficient concentration of the solution, a tight sodium alginate-calcium gel layer can be formed on the surface of the material, but ions will still continue to occur in the gel layer. Cross-linking reaction, as the degree of cross-linking increases, the water that can be retained in it is continuously squeezed out, and finally a dense hydrophobic film is formed on the surface of the material, and the material as a whole becomes hydrophobic, which is completely unfavorable for the crawling and regeneration of tissues

If treated with a low concentration of solvent and sizing agent, due to the strong non-directional charge interaction between sodium alginate carboxyl anions and calcium cations, as the reaction proceeds, the anions and cations in the solution will continue to enrich toward the initial crosslinking point. Agglomeration or even precipitation, resulting in the inability to form a uniform gel, which eventually leads to fragmentation due to internal force, unable to adhere to the material, or even adhesion to the wound because the material is too water-absorbent

Therefore, it is difficult to make the material have a short-term anti-adhesion effect by controlling the concentration of the sol and the setting solution

[0007] The reason is that its ionic cross-linking is too strong and uncontrollable

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