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Anti-adhesion composition for coating of tissue repair film, and use method of anti-adhesion composition

A technology of tissue repair and composition, which is applied in coating, drug delivery, pharmaceutical formulation, etc., can solve the problems of unfavorable tissue crawling, regeneration, uncontrollable, and fragmentation, and reduce secondary operations and follow-up care and treatment , reduce the accumulation of antigen concentration, improve the effect of tolerance

Active Publication Date: 2017-11-28
GUANGZHOU YUEQING REGENERATION MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when coating a high-concentration sol on the surface of the material and setting the shape, due to the large number of initial crosslinking points and sufficient concentration of the solution, a tight sodium alginate-calcium gel layer can be formed on the surface of the material, but ions will still continue to occur in the gel layer. Cross-linking reaction, as the degree of cross-linking increases, the water that can be retained in it is continuously squeezed out, and finally a dense hydrophobic film is formed on the surface of the material, and the material as a whole becomes hydrophobic, which is completely unfavorable for the crawling and regeneration of tissues
If treated with a low concentration of solvent and sizing agent, due to the strong non-directional charge interaction between sodium alginate carboxyl anions and calcium cations, as the reaction proceeds, the anions and cations in the solution will continue to enrich toward the initial crosslinking point. Agglomeration or even precipitation, resulting in the inability to form a uniform gel, which eventually leads to fragmentation due to internal force, unable to adhere to the material, or even adhesion to the wound because the material is too water-absorbent
Therefore, it is difficult to make the material have a short-term anti-adhesion effect by controlling the concentration of the sol and the setting solution
[0007] The reason is that its ionic cross-linking is too strong and uncontrollable

Method used

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  • Anti-adhesion composition for coating of tissue repair film, and use method of anti-adhesion composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take 30 parts of sodium alginate (in the state of 1% aqueous solution, the viscosity is 0.2~0.3 Pa s), 20 parts of polymer (hydroxypropyl methylcellulose, weight average molecular weight ≥ 20000) for filling, oligomeric anion ( 40 parts of oligomeric sodium alginate with a weight average molecular weight of 1000), mix well, measure 1.5g of the composition, fully swell it in water, and prepare it as a jelly solution with a concentration of 1.5% wt. After fully soaking in the water, take out the soaked membrane material, blot the residual liquid on the surface, spread it out and immerse it in 0.5%wt calcium chloride aqueous solution for 2min, take it out, wash it, and freeze-dry it to get the final product.

Embodiment 2

[0041] Take 60 parts of sodium alginate (in the state of 1% aqueous solution, the viscosity is 0.3~0.4 Pa s), 10 parts of polymer for filling (hyaluronic acid, weight average molecular weight ≥ 20000), oligomeric anion (weight average molecular weight 8000 oligomeric γ-polyglutamic acid) 40 parts, mixed uniformly, measured 0.1g of the composition, fully swelled in saline, prepared as a jelly solution with a concentration of 0.1 wt%, and tissue repair membrane in Fully soak in the colloidal solution, take out the soaked membrane material, blot the residual liquid on the surface, spread it out and immerse it in 2%wt calcium chloride aqueous solution for 30min, take it out, wash it, and freeze-dry to obtain the final product.

Embodiment 3

[0043] Take 40 parts of sodium alginate (in the state of 1% aqueous solution, the viscosity is 0.35~0.45 Pa s), 15 parts of polymer for filling (konjac glucomannan, weight average molecular weight ≥ 20000), oligomeric anion (weight Oligomerized oxidized cellulose with an average molecular weight of 3000) 10 parts, mix evenly, measure 0.5g of the composition and fully swell it in a physiological buffer solution, prepare a jelly solution with a concentration of 0.5% wt, and place the tissue repair membrane in the jelly Fully soak in the solution, take out the soaked membrane material, blot the residual liquid on the surface, spread it out and immerse it in 1%wt calcium chloride aqueous solution for 10min, take it out, wash it, and freeze-dry to obtain the final product.

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Abstract

The invention discloses an anti-adhesion composition for coating of a tissue repair film, and a use method of the anti-adhesion composition. The anti-adhesion composition comprises components in parts by weight as follows: 30-60 parts of sodium alginate, 10-20 parts of filling macromolecules, and 10-40 parts of oligomerized anions. At the initial period, the composition provides a good anti-adhesion character, but after 1-2 weeks, the anti-adhesion function is gradually lost. When being used for certain clinical operation materials, the composition provided by the invention can enable a biological tissue repair film and tissue to slowly fuse, so that the interreaction of the repair film and the tissue is buffered, the concentration accumulation of antigens possibly casing immunoreaction is reduced, and the tolerance of the tissue to a heterologous biological material is improved. Application provided by the invention can reduce the difficulty in a clinical operation, a second operation and subsequent nursing and treatment are reduced, and requirements for special materials are met.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an anti-adhesion composition for tissue repair membrane coating and an application method thereof. Background technique [0002] After the local tissue is damaged or died due to some pathogenic factors, it will be repaired by the regeneration of adjacent healthy cells to restore the integrity of the tissue. The speed and completeness of the process are affected by many factors. In addition to the type of damaged tissue, these factors also include injury factors, nutrition, blood supply, infection, and the number of tissue defects. The tissue repair of the biological body generally includes coagulation, inflammation and repair phases, in which the coagulation phase is completed within a few minutes, the inflammation phase may last for 2-7 days, and the repair phase lasts for several weeks or even longer. In some severe cases, complete The tissue repair may even tak...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L27/34
CPCA61L27/34A61L31/10A61L2400/04A61L2420/06C08L5/04
Inventor 李贤别拓铭易静楠官习鹏
Owner GUANGZHOU YUEQING REGENERATION MEDICINE TECH CO LTD