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A kind of preparation method of skin-adhesive nano silver ion antibacterial dressing

A nano-silver ion, adhesive technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of non-bacterial, poor air permeability, low comfort, etc., and achieve the effect of no skin residue, strong affinity, and not easy to fall off

Active Publication Date: 2020-04-28
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a preparation method of skin-adhesive nano-silver ion antibacterial dressing, which solves the problems of low comfort, poor air permeability and no antibacterial in the prior art

Method used

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  • A kind of preparation method of skin-adhesive nano silver ion antibacterial dressing
  • A kind of preparation method of skin-adhesive nano silver ion antibacterial dressing
  • A kind of preparation method of skin-adhesive nano silver ion antibacterial dressing

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preparation example Construction

[0021] The present invention provides a kind of preparation method of skin-adhesive nano-silver ion antibacterial dressing, and concrete steps are as follows:

[0022] Step 1, mix chloroform and ethanol as a pure solvent according to a volume ratio of 1 to 3:1 as a solvent, dissolve polylactic acid and polyethylene glycol with a mass percentage concentration of 8% to 20%, and form a mixed solution, wherein polylactic acid The volume ratio to polyethylene glycol is 1 to 4:1;

[0023] Step 2, adding the mixed solution obtained in step 1 to the electrospinning device, under the conditions of a voltage of 15KV-30KV and a spinning speed of 0.8ml / h-1.2ml / h, the receiving distance is in the range of 5cm-15cm, Receive a dressing with a thickness of 0.1 mm to 0.8 mm, soak the received dressing in ethanol with a mass percentage concentration of 70% to 75%, sterilize it for 90 min to 180 min, take it out and dry it;

[0024] Step 3: Soak the dressing obtained after the treatment in step...

Embodiment 1

[0033] Step 1, chloroform and ethanol as a pure solvent are mixed according to a volume ratio of 1:1 as a solvent, and polylactic acid and polyethylene glycol with a mass percentage concentration of 8% are dissolved to form a mixed solution, wherein polylactic acid and polyethylene glycol The volume ratio is 1:1;

[0034] Step 2, add the mixed solution obtained in step 1 to the electrospinning device, under the conditions of 15KV voltage and spinning speed of 0.8ml / h, the receiving distance is 5cm, and the receiving thickness is 0.8mm. Dressing, the received dressing Soak in 70% ethanol to sterilize for 180min, take it out and dry it;

[0035] Step 3: Soak the dressing obtained after the treatment in step 2 in a silver nitrate solution with a concentration of 5% by mass for 3 minutes, take it out and dry it to prepare a skin-adhesive nano-silver ion antibacterial dressing.

Embodiment 2

[0037] Step 1, chloroform and ethanol as a pure solvent are mixed according to a volume ratio of 3:1 as a solvent, and polylactic acid and polyethylene glycol with a mass percentage concentration of 8% are dissolved to form a mixed solution, wherein polylactic acid and polyethylene glycol The volume ratio is 4:1;

[0038] Step 2, add the mixed solution obtained in step 1 to the electrospinning device, under the conditions of 30KV voltage and spinning speed of 1.2ml / h, the receiving distance is 15cm, and the receiving thickness is 0.1mm. Dressing, the received dressing Soak in ethanol with a mass percentage concentration of 75% for 90 minutes to sterilize, take it out and dry it;

[0039] Step 3: Soak the dressing obtained after the treatment in step 2 in a silver nitrate solution with a mass percent concentration of 50% for 5 minutes, take it out and dry it to prepare a skin-adhesive nano-silver ion antibacterial dressing.

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Abstract

The invention discloses a preparation method for skin adhering type nano-silver ion anti-microbial dressing. The method comprises the following steps: mixing the pure solvent chloroform and ethyl alcohol at volume ratio of (1-3):1, and by taking the mixture as a solvent, dissolving the polylactic acid and polyethylene glycol at volume ratio of (1-4):1 in the mass concentration of 8%-20%; adding the acquired mixed solution into an electrostatic spinning device for preparing the dressing; sterilizing the acquired dressing by utilizing a sterilizing method, taking out and airing; andsoaking the aired dressing into a silver nitrate solution, taking out and then airing, thereby acquiring the skin adhering type nano-silver ion anti-microbial dressing. The invention has the advantages that the use is comfortable, no pressure-sensitive adhesive is required for fixing, the problems of poor air permeability, poor adhesion, low fitting degree, adhesion to wound and incapability of isolating from and resisting against bacteria of the traditional medical dressing can be solved, the skin motion and sweat are not influenced in the use process and the dressing is thin and soft, reusable and free from residue on the skin.

Description

technical field [0001] The invention belongs to the technical field of medical auxiliary products, and in particular relates to a preparation method of a skin-adhesive nano-silver ion antibacterial dressing. Background technique [0002] Protection and antimicrobial healing of acute and chronic cutaneous wounds are common clinical challenges. Long-term medical practice has confirmed that dressings play an important role in antibacterial and healing promotion. Traditional cotton fiber or polymer textile dressings are used as wound barriers, which have low adhesion to the skin and poor comfort. They need to be fixed with adhesive strips, which affect normal physiological metabolism such as skin sweating. The ability to isolate bacteria is weak, and they must be used frequently Change to avoid bacterial growth in the dressing itself. At the same time, sticky substances such as pressure-sensitive adhesives used as fixed dressings can cause skin allergic reactions. [0003] Mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/08A61L15/42A61L15/44A61L15/46
CPCA61L15/08A61L15/26A61L15/42A61L15/44A61L15/46A61L2300/104A61L2300/404C08L67/04C08L71/02
Inventor 沈文史康洁张宁
Owner SHAANXI UNIV OF SCI & TECH
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