A kind of external medicinal oil for treating solar dermatitis and preparation method thereof

A technology for medicated oil and dermatitis, which is applied in the field of external medicinal oil for treating solar dermatitis and its preparation, can solve the problems of unsatisfactory treatment effect and the like, and achieves the effects of a preparation method without side effects, fast onset of effect and short course of treatment

Active Publication Date: 2019-10-15
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the treatment effect is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1, the preparation of test sample

[0017] (1) Sample 1 formula: 10 parts of pearl powder, 8 parts of calcined gypsum, and 6 parts of calcined mother-of-pearl.

[0018] (2) Sample 2 formula: 10 parts of pearl powder, 8 parts of calcined gypsum, and 1 part of calcined mother-of-pearl.

[0019] (3) Formula of sample 3: 10 parts of pearl powder, 1 part of calcined gypsum, and 6 parts of calcined mother-of-pearl.

[0020] (4) Formula of sample 4: 1 part of pearl powder, 8 parts of calcined gypsum, and 6 parts of calcined mother-of-pearl.

[0021] (5) Formula of sample 5: 20 parts of pearl powder, 5 parts of calcined gypsum, and 10 parts of calcined mother-of-pearl.

[0022] (6) Preparation method: according to the formula, the raw materials are pulverized into fine powder according to a certain weight ratio, and after passing through a 400 mesh sieve, the fine powder is placed in 8 times the volume of mixed oil, each of which is 50% by white sesame oil and came...

Embodiment 2

[0023] Embodiment 2, sample-clinical efficacy test

[0024] (1) General information

[0025] A total of 32 cases were treated (23 males and 9 females). The youngest is 19 years old, the oldest is 46 years old, and the average is 34.7 years old; the shortest course of disease is 0.5 days, and the longest is 3 days. The sun exposure time is 2 to 8 hours. All cases developed edema and erythema with clear borders from 3 hours to more than 10 hours after sun exposure, and 26 cases (22 males, 4 females) also showed symptoms such as bullae and erosion, and the affected area had obvious burning pain, itching or tightness. Severe cases may be accompanied by systemic symptoms such as headache, palpitations, nausea, and fever.

[0026] (2) Treatment methods

[0027] First use 0.9% sodium chloride injection to clean the wound surface (for seriously polluted wound surface, add 0.1% bromogeramine solution when cleaning), then dry the wound surface with sterile dry gauze, and then apply...

Embodiment 3

[0036] Embodiment 3, sample two clinical curative effect test

[0037] After 7 days of treatment in 25 patients, 15 cases were cured, 1 case was markedly effective, 0 cases were effective, and 9 cases were ineffective. The recovery rate was 60%, and the total effective rate was 64%. The 7.2±2.1 before the application of the oil decreased to 7.0±1.9 (compared with before the application of the oil, the difference was not statistically significant P>0.05) and 4.5±1.3 (compared with the before the application of the oil, the difference was statistically significant P0.05) and 6.4±2.1 2.8 (compared with before applying the oil, the difference was statistically significant P<0.05); during the entire treatment process, all patients had no clinical adverse reactions.

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PUM

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Abstract

The invention relates to an externally applied medicinal oil for treating solar dermatitis, and a preparation method thereof. The externally applied medicinal oil comprises a medicinal component and an oily matrix, and the medicinal component comprises 1-20 parts of pearl powder, 1-10 parts of calcined gypsum and 1-10 parts of calcined Concha Margaritifera; and the oily matrix includes white sesame oil, or camellia oil, or white sesame oil and camellia oil mixed oil. The preparation method of the externally applied medicinal oil comprises the following steps: crushing the medicinal raw materials to prepare fine powder; and adding the oily matrix according to a solid-liquid ratio of 1:(8-10), immersing the fine powder at an oil temperature of 80-120 DEG C for 12-48 hours, and filtering the obtained mixture, and taking obtained oil to prepare the externally applied medicinal oil. Experiments prove that the medicinal oil has an obvious curative effect on the solar dermatitis, and has the advantages of quick effect, short treatment course, low cost, simplicity in preparation, and no side effects.

Description

technical field [0001] The invention relates to an external medicinal oil for treating solar dermatitis and a preparation method thereof. Background technique [0002] Solar dermatitis, also known as sunburn or sunburn, is an acute phototoxic reaction or acute inflammatory reaction of the skin caused by excessive sunlight on the exposed parts of the skin. A few hours after the affected part is exposed to the sun, edema and erythema with clear borders appear on the exposed skin. In severe cases, blisters may appear, and the affected part has obvious burning or tingling sensation. Symptoms often reach a peak within 24 hours. After the erythema and edema subside, there are bran-like or large scales of desquamation and mild pigmentation. Severe cases may be accompanied by general malaise symptoms such as headache, palpitations, nausea, and fever. Traditional Chinese medicine believes that solar dermatitis is mostly caused by the evil of sunlight and heat invading the skin, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/618A61P17/00A61K33/06
Inventor 李沛波姚宏亮苏薇薇王永刚彭维吴忠
Owner SUN YAT SEN UNIV
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