Saurida elongata peptide with function of reducing blood pressure

A technology of blood pressure-lowering peptide and long snake mullet, applied in the field of small peptide preparation, can solve the problems of poor competitiveness, low product added value, backward processing technology, etc., and achieve the effect of increasing NO content

Inactive Publication Date: 2017-12-15
浦江县泰如食品科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The total amount of marine biological protein resources in China ranks among the best in the world. However, in my country's current protein aquatic products, except for a part of direct consumption, most of them are made into food thr

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A long snake mullet antihypertensive peptide, comprising step-by-step enzymatic hydrolysis, isoelectric point precipitation, secondary ultrafiltration and nanofiltration, and freeze-drying. The step-by-step enzymatic hydrolysis step is to add pure water homogenate to long snake mullet minced meat, then add Porphyra zebra protease and active short peptide for enzymatic hydrolysis, adjust the pH and then add flavor protease for enzymatic hydrolysis to obtain an enzymatic hydrolysis solution. Marine biological proteins are very different from terrestrial biological proteins in terms of amino acid composition and amino acid sequence, and many different active peptides can be released by hydrolyzing marine products with marine proteases. First use Porphyra zebra protease, and then continue to use flavor protease to enzymatically hydrolyze, and the blood pressure-lowering peptide with the effect of lowering blood pressure and protecting the myocardium can be obtained. At pres...

Embodiment 2

[0025] A long snake mullet antihypertensive peptide, comprising step-by-step enzymatic hydrolysis, isoelectric point precipitation, secondary ultrafiltration and nanofiltration, and freeze-drying.

[0026] The most preferred preparation method of a long snake mullet hypotensive peptide, the specific steps are:

[0027] 1) Step-by-step enzymatic hydrolysis: add pure water homogenate to long snake mullet minced meat, then add Porphyra zebra protease and active short peptide for enzymatic hydrolysis, adjust the pH and add flavor protease for enzymatic hydrolysis to obtain an enzymatic hydrolysis solution. 26 times the volume of water was added to the ground snake mullet meat, the amount of Porphyra zebra protease added was 6wt‰, the enzymatic hydrolysis temperature was 32°C, the pH was 8.0, the enzymatic hydrolysis time was 34min, and the enzyme was inactivated after the enzymatic hydrolysis. The amount of flavor protease added is 2wt%, the pH of enzymolysis is 6.4, the temperatu...

Embodiment 3

[0032] A long snake mullet antihypertensive peptide, comprising step-by-step enzymatic hydrolysis, isoelectric point precipitation, secondary ultrafiltration and nanofiltration, and freeze-drying.

[0033] The most preferred preparation method of a long snake mullet hypotensive peptide, the specific steps are:

[0034] 1) Step-by-step enzymatic hydrolysis: add pure water homogenate to long snake mullet minced meat, then add Porphyra zebra protease and active short peptide for enzymatic hydrolysis, adjust the pH and add flavor protease for enzymatic hydrolysis to obtain an enzymatic hydrolysis solution. Add 30 times the volume of water to the minced long snake mullet meat, add 5.5wt‰ of Porphyra zebra protease, enzymolysis temperature is 32°C, pH is 8.0, enzymolysis time is 34min, and the enzyme is inactivated after the enzymolysis is completed. The added amount of flavor protease is 1.8wt%, the pH of enzymolysis is 6.4, the temperature of enzymolysis is 55°C, and the time of e...

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Abstract

The invention discloses a saurida elongata peptide with the function of reducing blood pressure. A method comprises steps as follows: step-by-step enzymolysis, isoelectric precipitation, second ultrafiltration, nanofiltration and freeze drying. Marine protease and land protease are adopted for synergetic enzymolysis, porphyra yezoensis protease is adopted firstly, a flavourzyme is adopted continuously on the basis, and the blood-pressure-reducing peptide with the functions of reducing blood pressure and protecting myocardial can be obtained. The saurida elongata peptide with the function of reducing blood pressure has the benefits as follows: the prepared blood-pressure-reducing peptide has the functions similar to those of GABA (gamma-aminobutyric acid), the blood pressure reducing function is related to an RAS (renin-angiotensin system), and the content of ANG-II (angiotensin II) in blood serum of a human body is reduced and the content of NO is increased if people take the saurida elongata peptide for a long time.

Description

technical field [0001] The invention relates to the field of small peptide preparation, in particular to a long snake mullet blood pressure lowering peptide. Background technique [0002] Long snake mullet (Saurida elongata), also known as snake mullet, fairy shuttle, Xiangsuo, long lizard fish, is a warm-water offshore sea-dwelling fish. Body elongated cylindrical, slightly thicker in the middle. The body length is about 450mm. Hi inhabits sea areas with mud and silt bottoms. Swimming quickly, but the range of movement is not large, and they do not perform long-distance migration. Distributed in China's coastal areas, North Korea, and Japan, it is one of the main economic fishes in my country, with a large annual output. [0003] Due to the low content of naturally occurring marine active peptides in organisms and the difficulty of extraction, it is difficult to meet the needs of mass production and supply, and the cost of chemical synthetic peptides is expensive. Ther...

Claims

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Application Information

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IPC IPC(8): C12P21/06C07K14/46C07K1/36C07K1/34C07K1/30A61P9/12
CPCC12P21/06C07K14/461
Inventor 刘洋
Owner 浦江县泰如食品科技有限公司
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