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Application of water extracts of okra to protection of function of digestive tract

A technology of water extract and water extract, applied in the field of medicine

Inactive Publication Date: 2017-12-22
广东维尼健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nowadays, chemical or natural drugs are mostly used in clinical practice to directly act on the digestive tract, but the research on protecting the function of the digestive tract is still in a relatively primitive stage, and it is difficult to meet the needs of modern life.

Method used

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  • Application of water extracts of okra to protection of function of digestive tract
  • Application of water extracts of okra to protection of function of digestive tract
  • Application of water extracts of okra to protection of function of digestive tract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: the preparation of okra water extract

[0035] Wash the fresh okra tender fruit and dry it, crush the dried fruit, mix the fine powder with water, extract the fine powder in the extraction tank for several hours, take the supernatant after centrifugation, concentrate and spray dry, and the obtained is okra water extraction thing. The aqueous extract is easily soluble in water.

Embodiment 2

[0036] Embodiment 2: the proliferative effect (MTT method) of okra water extract on GES-1 gastric mucosal cells

[0037] GES-1 gastric mucosal cells in the logarithmic growth phase were taken, and 100 μL of cell suspension was inoculated into each well of a 96-well culture plate. 37°C, 5% CO 2 Incubate overnight. The next day, the cell plate was taken out, the supernatant was discarded, and 100 μL of different concentrations of okra water extract (diluted in medium) were added to each well, and 6 replicate wells were made for each concentration well. Add 100 μL of culture medium to the control group, make another well without adding cells, and only add culture medium (use this well to set zero for colorimetry). Add PBS to the periphery to maintain the moisture inside the cell culture plate, at 37°C, 5% CO 2 cultivated under conditions. At the end of the incubation time, 10 μL of MTT solution with a concentration of 5 mg / ml was added to each well successively, and the incub...

Embodiment 3

[0040] Embodiment 3: Aqueous extract of okra weakens the effect of alcohol-induced gastric injury in mice

[0041] SPF level BALB / c mice were selected, fasted for 24 hours before the experimental operation, and randomly divided into 4 groups (n=6): the first group was the normal control group, the second group was the alcohol treatment group, and the third group was alcohol + okra water Extract high-dose group, the fourth group is alcohol + okra water extract low-dose group. For specific dosing regimens, see image 3 . The mice were sacrificed after anesthesia, the stomach was taken out, the inside of the stomach was opened, cleaned and fixed, and photographed at a resolution of 72dpi (2816 x 2112 pixels). Use computer software to count the area percentage of mucosal bleeding area and injured area. Such as Figure 4 The results showed that the area of ​​gastric mucosal injury accounted for about 40% of the total area in the alcohol treatment group, and administration of ok...

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Abstract

The invention discloses an application of water extracts of okra to preparation of a drug for protecting the function of the digestive tract. The water extracts of okra are prepared according to the steps of cleaning and then drying fresh young okra fruits, smashing the dried fruits, mixing fine powder with water, conducting digestion on fine powder in an extraction tank for several hours, taking supernatant after centrifugation, and conducting concentration and then spray drying to obtain the water extracts of okra. A brand-new approach is provided for protection of the function of the digestive tract. The single-action limitation of chemical drugs in treating and preventing digestive diseases is changed through mucosa protection, tissue regeneration and repair, regulation of the gastrointestinal environment and the like, and technical support is provided for further development of a series of drugs or functional foods for gastrointestinal protection.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new application of okra water extract, in particular to the application of okra water extract in protecting digestive tract function. Background technique [0002] Okra ((Abelmoschus moschatu), coffee ambrette, croissant, croissant, etc., also known as Okra abroad, is an annual herb of the genus Okra (Hibiscus esulentus L.) in the Malvaceae family. It is native to tropical regions of Africa, and was born in the 1990s It was first introduced into the inland of my country, and now it is cultivated all over the country, and the yield per mu is about 3000 kilograms. The staple food part of okra is tender fruit, and its fruit is rich in nutrition, rich in protein, carbohydrates, unsaturated fatty acids, vitamins and minerals, and belongs to medicine. homologous plants [1] . [0003] Studies have shown that okra can significantly reduce the proliferation of mouse melanoma cells (B160F10) [2] ,...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/00A61P1/04A61K131/00
CPCA61K36/185A61K2236/331A61K2236/51A61K2236/53
Inventor 吴宝剑张天鹏邢会杰赵梦静
Owner 广东维尼健康科技有限公司
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