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Method for preparing arbitrary concentration, racemic dl-lactic acid by mixing method

A technology of racemization and mixing, applied in organic chemistry methods, organic chemistry, etc., can solve the problems that the inherent quality of DL-lactic acid products cannot be guaranteed, and achieve controllable key quality indicators, controllable concentration, and reliable product application effects Effect

Active Publication Date: 2020-08-04
湖北壮美生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because if D-lactic acid and L-lactic acid are simply mixed according to the weight ratio without other treatment, there is no guarantee that the mixed DL-lactic acid product will be the same or similar to the "racemic mixed DL-lactic acid" produced by the above two methods intrinsic quality of

Method used

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  • Method for preparing arbitrary concentration, racemic dl-lactic acid by mixing method
  • Method for preparing arbitrary concentration, racemic dl-lactic acid by mixing method
  • Method for preparing arbitrary concentration, racemic dl-lactic acid by mixing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Preparation of dilute DL-lactic acid

[0029] A. After the cleaning of the system equipment is completed, 1000Kg of L-lactic acid (L-lactic acid accounts for 98.64%, D-lactic acid accounts for 1.36%, optical rotation -14, and the total content of lactic acid is 90.27%) that has completed the evaluation (acceptance) is input once into the reaction tank, add 1600kg of distilled water to dilute under stirring state, so that the lactic acid content is controlled between 32-38%. Start the reactor heating device, heat up to 55.5°C under continuous stirring, drop in 3kg 767 activated carbon for injection, and continue stirring for 30 minutes. Put the feed liquid into the transfer tank at one time and keep it warm for 3 hours. During the period, take samples and filter at any time to measure the specific rotation. When the rotation is -3.5, filter the feed liquid in the transfer tank through a candle filter and then input it for leveling. Can. After the feeding is complete...

Embodiment 2

[0051] 1. Preparation of dilute DL-lactic acid. Method is with embodiment 1.

[0052] 2. Preparation of concentrated DL-lactic acid

[0053] (1) After pouring 5500kg of the prepared dilute DL-lactic acid into the reaction tank at one time, turn on the stirring device of the reaction tank.

[0054] (2) Check the vacuum system matched with the reaction tank, open the cooling water valve of the spiral wound tube condenser, start the water circulation vacuum pump, and turn on the reaction tank heating device until the system pressure drops to 2700-2000Pa.

[0055] (3) When the system pressure is 2400-2200Pa, when the temperature of the material in the reaction tank rises to 85-90°C (corresponding to the target content according to experience), stop heating, remove and stop the vacuum.

[0056] (4) Add 3kg of 767 activated carbon for injection and stir for 5-10min.

[0057] (5) Input the feed liquid into the transfer tank at one time, keep the feed liquid at 50-80°C for 15 minut...

Embodiment 3

[0064] 1. Preparation of dilute DL-lactic acid. Method is with embodiment 1.

[0065] 2. Refining of dilute DL-lactic acid

[0066] (1) After pouring 5000kg of the prepared dilute DL-lactic acid into the reaction tank at one time, turn on the stirring device of the reaction tank.

[0067] (2) Check the vacuum system matched with the reaction tank, open the cooling water valve of the spiral wound tube condenser, start the water circulation vacuum pump, and turn on the reaction tank heating device until the system pressure drops to 2700-2000Pa.

[0068] (3) When the system pressure is 2400-2200Pa, when the temperature of the material in the reaction tank rises to 85-90°C (corresponding to the target content), stop heating, remove and stop the vacuum.

[0069] (4) Add 3kg of 767 activated carbon for injection, and stir for 5-10 minutes.

[0070] (5) Input the feed liquid into the transfer tank at one time, keep the feed liquid at 50-80°C for 15 minutes.

[0071] (6) The materia...

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Abstract

The invention discloses a method for preparing racemized DL-lactic acid with an arbitrary concentration by using a mixing process. The method comprises the following steps: firstly carrying out a series of pretreatment such as dilution, hydrolysis and detection of D-lactic acid and L-lactic acid which are used as raw materials in a content of 80-100%, then mixing the raw materials, sampling, measuring, correspondingly adjusting, then concentrating the raw materials to a target content, and obtaining thermally stable refined DL-lactic acid products with fewer non-lactic acid impurities, higher whole quality and arbitrary concentration. The method overcomes the defect of quality of the DL-lactic acid products which are obtained by only mixing D-lactic acid and L-lactic acid according to a weight ratio without other corresponding treatment, has the advantages of simple process and high equipment utilization rate; the quality of the products is higher than that of the products of the same industry in China and is equivalent to that of imported products.

Description

technical field [0001] The invention relates to the technical field of chemical engineering and technology, in particular to a method for preparing racemic DL-lactic acid of arbitrary concentration by a mixing method. Background technique [0002] The chemical name of lactic acid is 2-hydroxypropionic acid (also known as α-hydroxypropionic acid), molecular formula C 3 h 6 o 3 , relative molecular mass 90.08. Lactic acid is the smallest chiral molecule in nature. Since the α-position carbon atom in the molecule is an asymmetric carbon atom, it has two configurations, L and D. There are left-handed L-lactic acid, right-handed D-lactic acid and racemic There are three forms of spin-type DL-lactic acid (theoretically, it should be in the molecular free state, a mixture of D and L in equal proportions). [0003] However, the usual lactic acid products are not a single pure substance. Besides water, lactic acid, polylactyl lactic acid, lactide and lactic anhydride are also lik...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07B55/00C07C59/08
CPCC07B55/00C07C59/08
Inventor 郑修萍汪芳芳付振宇陈传武丁广建
Owner 湖北壮美生物科技有限公司
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