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Preparation method for monodisperse micro droplets based on capillary pipe

A technology of capillary and micro-droplets, which is applied in the direction of mixing methods, chemical instruments and methods, and laboratory containers, etc., can solve the problems of difficult popularization, high production costs, complex micro-processing processes, etc., and achieve simple and reliable control , fast droplet speed, simple and flexible device construction

Active Publication Date: 2017-12-26
INT ACAD OF OPTOELECTRONICS AT ZHAOQING SOUTH CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the droplets prepared by microfluidic technology have the advantages of good monodispersity and uniform and controllable droplet size compared with the traditional method, the microchannel structure of the microfluidic system can be designed according to the needs; but usually involves more complicated The micro-processing process, so the production cost is high, it is difficult to popularize the application

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  • Preparation method for monodisperse micro droplets based on capillary pipe
  • Preparation method for monodisperse micro droplets based on capillary pipe
  • Preparation method for monodisperse micro droplets based on capillary pipe

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Experimental program
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Embodiment 1

[0041] Such as figure 1 and 2 Shown, be the experimental device that the present invention adopts, concrete experimental operation is:

[0042] Firstly, the continuous phase solution was prepared by dissolving 2.59 g sodium dodecyl sulfate SDS in 99.86 g deionized water, heating and stirring at low temperature (30°C, 350 rpm) for 2 h to form a uniform solution. Then take a small amount of solution and transfer it into a square transparent glass cell (25mm×25mm×25mm); then prepare the dispersed phase (internal phase) solution, add 0.1 g of pure blue ink to 20 mL of n-hexadecane, and vortex Shake for 1 min to make it evenly mixed. Then pipette this solution into the syringe of the syringe pump (try to avoid air entering the syringe), and connect a quartz capillary (20 μm inner diameter, 88 μm outer diameter) to the syringe.

[0043] Insert the quartz capillary vertically into the glass cell containing the continuous phase, and adjust the distance between the capillary opening...

Embodiment 2

[0045] Firstly, the continuous phase solution was prepared by dissolving 2.59 g sodium dodecyl sulfate SDS in 99.86 g deionized water, heating and stirring at low temperature (30°C, 350 rpm) for 2 h to form a uniform solution. Then take a small amount of solution and transfer it into a square transparent glass cell (25mm×25mm×25mm); then prepare the dispersed phase (internal phase) solution, add 0.1 g of pure blue ink to 20 mL of n-hexadecane, and vortex Shake for 1 min to make it evenly mixed. Then transfer this solution into the syringe of the syringe pump (try to avoid air entering the syringe), and connect the quartz capillary (20 μm inner diameter, 88 μm outer diameter) to the syringe.

[0046] Insert the quartz capillary vertically into the glass cell containing the continuous phase, and adjust the distance between the capillary opening and the bottom of the glass cell ( d ) is 5, 15 and 30 μm; the flow rate of the inner phase in the capillary is controlled by a syringe...

Embodiment 3

[0049] Firstly, the continuous phase solution was prepared by dissolving 2.59g sodium dodecyl sulfate SDS in 99.86g deionized water, heating and stirring at low temperature (30°C, 350 rpm) for 2 h to form a uniform solution. Then take a small amount of solution and transfer it into a square transparent glass cell (25mm×25mm×25mm); then prepare the dispersed phase (internal phase) solution, add 0.1 g of pure blue ink to 20 mL of n-hexadecane, and vortex Shake for 1 min to make it evenly mixed. Then pipette this solution into the syringe of the syringe pump (try to avoid air entering the syringe), and connect a quartz capillary (20 μm inner diameter, 88 μm outer diameter) to the syringe.

[0050] Insert two quartz capillaries vertically into the glass cell filled with continuous phase, adjust the distance between the capillary opening and the bottom surface of the glass cell ( d ), so that it is ~5 μm; the flow rate of the inner phase in the capillary is controlled by a syringe...

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Abstract

The invention provides a preparation method for monodisperse micro droplets based on a capillary pipe, wherein the preparation method comprises the steps: the capillary pipe is inserted into a vessel containing a continuous phase solution, the capillary pipe contains a dispersed phase solution, and the distance d between a pipe port of the capillary pipe and the bottom surface of the vessel is controlled to be 0-500 [mu]m; the continuous phase solution is kept still, and the flow rate Q of the dispersed phase solution in the capillary pipe is controlled to be 0.01 [mu]L / min-10 [mu]L / min, to generate a controllable-size micro droplet emulsion. Based on a face that the capillary pipe is a microfluidic channel, high-throughput micro droplets are generated by a capillary pipe array, the price is low, control is simple and reliable, the speed of generation of the droplets is fast, interference is small, and the micro droplets are controllable in size and have potential applications in the fields of cosmetics or medicine and the like.

Description

technical field [0001] The invention belongs to the technical field of droplet generation and emulsion preparation, and more specifically relates to a method for preparing capillary-based monodisperse microdroplets. Background technique [0002] An emulsion is a mixture of at least two or more immiscible fluids, one of which is dispersed in the other in the form of droplets. Emulsion is ubiquitous in daily life, and has a wide range of applications in industry, such as food, pharmacy, cosmetics, etc., and as a new biochemical analysis platform, emulsion droplets have the advantages of high efficiency, high throughput, and low consumption. . [0003] In the traditional method of producing emulsions, emulsions can be prepared by inputting different forms of energy provided by the outside world, such as shaking, shaking, ultrasound, etc. However, the emulsion droplet size distribution produced by these methods is very wide, which seriously affects the reproducibility of dropl...

Claims

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Application Information

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IPC IPC(8): B01L3/00B01F3/08
CPCB01L3/50273B01L3/502784B01F23/4143B01F23/4105
Inventor 水玲玲梅利平金名亮
Owner INT ACAD OF OPTOELECTRONICS AT ZHAOQING SOUTH CHINA NORMAL UNIV