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Method for treating child cerebral palsy through neural precursor cells (NPC)

A technology of neural precursor cells and children with cerebral palsy, applied in the medical field, can solve the problems of nerve regeneration without directly preventing the process of brain injury, and achieve good differentiation and regulation, strong proliferation ability, and improved hand-eye coordination.

Inactive Publication Date: 2018-01-12
杨涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, great progress has been made in the etiology and pathogenesis of HIE, drug treatment and intervention measures, which have been extended to the gene and molecular level. Measures to promote regeneration of damaged nerves

Method used

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  • Method for treating child cerebral palsy through neural precursor cells (NPC)
  • Method for treating child cerebral palsy through neural precursor cells (NPC)
  • Method for treating child cerebral palsy through neural precursor cells (NPC)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Embodiment 1: as Figure 1-2 As shown, the present invention provides a method for neural precursor cells to treat children with cerebral palsy, comprising the steps of:

[0068] 1) Preoperative preparation:

[0069] (1) Preparation of the patient

[0070] 1. Preoperative examination

[0071] (1) Hematological examination: four items of immunity, three items of coagulation, six items of hepatitis B, liver and kidney function, blood routine, blood type;

[0072] (2) Electroencephalogram: Children with no seizures and suspicious seizures should undergo routine EEG examination; children with suspicious seizures and previous obvious convulsive seizures should undergo video EEG examination or 24-hour dynamic EEG monitoring;

[0073] (3) Imaging data: head MRI examination within half a year;

[0074] (4) Intellectual motor assessment before operation, using the comprehensive function assessment of disabled children, GMFM88 scale;

[0075] 2. Parents or legal guardians of...

Embodiment 2

[0123] Embodiment 2: as Figure 1-2 As shown, the clinical application of the method of treating children with cerebral palsy with neural precursor cells:

[0124] 1. Select the patient

[0125] (1) Indications

[0126] Children aged l-l4 with moderate to severe cerebral palsy;

[0127] (1) Children with CP who meet the diagnostic conditions and classification criteria for children with cerebral palsy formulated by the National Cerebral Palsy Conference in 1989;

[0128] (2) According to the GMFCS grading system, children with grades Ⅲ-Ⅴ;

[0129] (3) Spastic cerebral palsy, involuntary motor cerebral palsy, mixed cerebral palsy and ataxia cerebral palsy;

[0130] (4) Children with cerebral palsy whose rehabilitation treatment has failed for 6 months or whose rehabilitation treatment has contraindications;

[0131] (5) Exclude progressive genetic metabolic diseases.

[0132] (2) Contraindications

[0133] (1) Severe congenital heart disease, cardiac insufficiency;

[0...

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PUM

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Abstract

The invention discloses a method for treating child cerebral palsy through neural precursor cells. The method comprises the following steps: preoperative preparation, cell transplantation and postoperative treatment. The NPC in the invention is wide in source and convenient in collection, has high multiplication capacity and high cell viability, also has excellent differentiation regulation property and multi-potential differentiation, and can serve as a good carrier for gene therapy. Meanwhile, due to the test performed by the method, gross motor functions, such as lying and turning, sitting,walking and initiative grabbing and hand-eye coordination abilities, of cerebral palsy children treated within four weeks can be obviously improved. Therefore, according to the method disclosed by the invention, the cerebral injury process can be directly inhibited or regeneration of injured nerves can be promoted.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for treating children with cerebral palsy with neural precursor cells. Background technique [0002] It has been found that there are many factors that can cause neonatal brain damage, the most important of which is perinatal asphyxia and the resulting neonatal hypoxic-ischemic encephalopathy (hypoxia-ischemic encephalopathy, HIE). According to statistics, about 4‰ of full-term newborns will have perinatal asphyxia, and the incidence rate of premature infants will be higher. Among them, 20%-50% of the infants will die in the neonatal period due to brain damage caused by the disease, while the surviving infants There are also 25%-60% of children with persistent neurodevelopmental disorders, such as cerebral palsy, epilepsy, mental retardation and other sequelae. Among the newborns born in my country every year, there are about 300,000 asphyxiated children with permanent...

Claims

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Application Information

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IPC IPC(8): A61K35/30A61P25/00
Inventor 杨涛隋昳
Owner 杨涛
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