A kind of antibacterial poly(ε-caprolactone)/mimetic antimicrobial peptide electrospun fiber membrane and preparation method thereof
A technology of electrospun fibers and antimicrobial peptides, applied in the field of preparation of biopolymer materials, to achieve the effect of adjustable hydrophilicity and hydrophobicity, beneficial to sterilization and healing, and obvious antibacterial activity
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Embodiment 1
[0024] (1) Preparation of antibacterial poly(ε-caprolactone) / mimetic antimicrobial peptide electrospun fiber membrane
[0025] Configuration of the electrospinning solution: mix poly(ε-caprolactone) with a number average molecular weight of 80,000 and a polyhedral oligosilsesquioxane-polypeptide with a number average molecular weight of 8750 of the simulated antibacterial peptide at a mass ratio of 12:1 , dissolved in the solvent trifluoroethanol, and stirred for 48 hours to obtain an electrospinning solution with a uniform mass concentration of 130 mg / mL;
[0026] Inject the uniformly mixed electrospinning solution into a 5mL syringe, set the electrospinning voltage to 12kV, the flow rate of the electrospinning solution to 0.4mL / h, the receiving distance to 15cm, and the air humidity to 21%. Start the device for electrospinning, and obtain the PCL / mimetic antimicrobial peptide electrospun fiber membrane on the receiving device. The prepared poly(ε-caprolactone) / mimetic antim...
Embodiment 2
[0030] (1) Preparation of antibacterial poly(ε-caprolactone) / mimetic antimicrobial peptide electrospun fiber membrane
[0031] Mix poly(ε-caprolactone) with a number average molecular weight of 80,000 and a simulated antimicrobial peptide isobutyl-polypeptide with a number average molecular weight of 8080 at a mass ratio of 12:1, dissolve in the solvent trifluoroethanol, and stir for 54 hours , to obtain an electrospinning solution with a uniform mass concentration of 130 mg / mL;
[0032] Inject the homogeneously mixed electrospinning solution into a 5mL syringe, set the electrospinning voltage to 13kV, the flow rate of the electrospinning solution to 0.4mL / h, the receiving distance to 15cm, and the air humidity to 25%. The device was started to perform electrospinning, and poly(ε-caprolactone) / mimetic antimicrobial peptide electrospun fiber membrane was obtained on the receiving device. The prepared poly(ε-caprolactone) / mimetic antimicrobial peptide electrospun fiber membrane...
Embodiment 3
[0036] (1) Preparation of antibacterial poly(ε-caprolactone) / mimetic antimicrobial peptide electrospun fiber membrane
[0037] Poly(ε-caprolactone) with a number average molecular weight of 80,000 was mixed with polyethylene glycol-polypeptide with a number average molecular weight of 5320 of the simulated antimicrobial peptide at a mass ratio of 12:1, dissolved in the solvent trifluoroethanol, Stir for 42 hours to obtain an electrospinning solution with a uniform mass concentration of 130 mg / mL;
[0038] Inject the homogeneously mixed electrospinning solution into a 5mL syringe, set the electrospinning voltage to 12kV, the flow rate of the electrospinning solution to 0.4mL / h, the receiving distance to 15cm, and the air humidity to 18%. The device was started to perform electrospinning, and poly(ε-caprolactone) / mimetic antimicrobial peptide electrospun fiber membrane was obtained on the receiving device. The prepared poly(ε-caprolactone) / mimetic antimicrobial peptide electros...
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