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Multilayer coaxial fibrous bone repairing membrane material and preparation method thereof

A technology for bone repair and membrane material, which is used in fiber processing, medical science, non-woven fabrics, etc.

Active Publication Date: 2018-01-26
北京市创伤骨科研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Method used

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  • Multilayer coaxial fibrous bone repairing membrane material and preparation method thereof
  • Multilayer coaxial fibrous bone repairing membrane material and preparation method thereof
  • Multilayer coaxial fibrous bone repairing membrane material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0052] (1) Take 1 g of gelatin, add it to 10 mL of trifluoroethanol solvent, and stir magnetically at room temperature for 6 hours to obtain a solution A with a gelatin mass concentration of 0.1 g / mL;

[0053] (2) Add 0.01g of ciprofloxacin to solution A, stir magnetically at room temperature for 6h to obtain solution B, the mass ratio of ciprofloxacin to gelatin in solution B is 1 / 100;

[0054] (3) Take 0.2 g of polycaprolactone, add it to 10 mL of trifluoroethanol solvent, and stir magnetically at room temperature for 12 hours to obtain a solution C with a mass concentration of polycaprolactone of 0.02 g / mL;

[0055] (4) Add 0.8 g of gelatin to solution C, and magnetically stir at room temperature for 12 hours to obtain solution D. The mass ratio of polycaprolactone to gelatin in solution D is 20 / 80;

[0056] (5) Add 0.01 g of DFO to solution D, and magnetically stir at room temperature for 6 hours to obtain solution E. The ratio of the mass of DFO in solution E to the total...

Embodiment 2

[0065] (1) Take 0.2 g of polycaprolactone, add it to 10 mL of trifluoroethanol solvent, and stir magnetically at room temperature for 6 hours to obtain a solution A with a mass concentration of polycaprolactone of 0.02 g / mL;

[0066] (2) Add 0.8 g of gelatin to solution A, and magnetically stir at room temperature for 12 hours to obtain solution B. The mass ratio of polycaprolactone to gelatin in solution B is 20 / 80;

[0067] (3) Add 0.3g moxifloxacin to solution B, stir magnetically at room temperature for 6h to obtain solution C, the ratio of the mass of moxifloxacin in solution C to the total mass of polycaprolactone and gelatin is 30 / 100;

[0068] (4) Take 0.5 g of polycaprolactone, add it to 10 mL of trifluoroethanol solvent, and stir magnetically at room temperature for 6 hours to obtain a solution D with a mass concentration of polycaprolactone of 0.05 g / mL;

[0069] (5) Add 0.5 g of gelatin to solution D, and magnetically stir at room temperature for 12 hours to obtain...

Embodiment 3

[0079] (1) Take 0.2 g of polylactic acid, add it to 10 mL of N, N-dimethylformamide solvent, and magnetically stir at room temperature for 9 hours to obtain a solution A with a mass concentration of polylactic acid of 0.02 g / mL;

[0080] (2) Add the chitosan of 0.8g in solution A, magnetically stir 10h at room temperature, obtain solution B, the mass ratio of polylactic acid and chitosan in solution B is 20 / 80;

[0081] (3) Add 0.3g penicillin in solution B, magnetically stir at room temperature for 6h, obtain solution C, the ratio of the quality of penicillin in solution C to the total mass of polylactic acid and chitosan is 30 / 100;

[0082] (4) Take 0.4 g of polylactic acid, add it to 10 mL of N,N-dimethylformamide solvent, and magnetically stir at room temperature for 9 hours to obtain a solution D with a mass concentration of polylactic acid of 0.04 g / mL;

[0083] (5) Add the chitosan of 0.6g in the solution D, magnetically stir 10h at room temperature, obtain solution E, ...

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Abstract

The invention relates to a multilayer coaxial fibrous bone repairing material and a preparation method thereof, and belongs to the field of biological materials. The material is through an static spinning technology of biodegradable biodegradable aliphatic polyester and a natural polymer which have biocompatibility and are used as main raw materials through using a four-layer coaxial syringe needle. The fiber of the material has a multilayer coaxial structure, and an antibacterial and anti-inflammatory drug and an osteogenesis promoting drug can be added according to the bone repairing processat different levels. The material has an excellent biocompatibility and a controllable long-term drug release property. The drugs loaded in the fiber are released layer by layer with the proceeding of the bone repairing process in order to provide required corresponding substances for different bone repairing stages. The material can be controllably degraded in vivo as needed, so secondary surgery for taking out the material is avoided.

Description

technical field [0001] The invention relates to a preparation method of a multi-layer coaxial fiber bone repair membrane material, which belongs to the field of biological materials, and specifically relates to a kind of membrane material composed of fibers with a four-layer coaxial structure, and the drug release process is adapted to each stage of bone repair. Bone repair membrane material and preparation method thereof. Background technique [0002] Bone defect is a very common clinical trauma, and the bone repair process is very long, which mainly includes the hematoma and inflammation phase, the initial callus reaction phase, the cartilage formation phase, and the bone formation and remodeling phase. In the process of bone repair, cells secrete a variety of growth factors to play a role in different timing to ensure the repair of bone defects. [0003] Clinically, when a bone defect occurs, the best way is to perform bone grafting, mainly including autologous bone graf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/24A61L27/22A61L27/20A61L27/18A61L27/12A61L27/08A61L27/10A61L27/54A61L27/58D01D5/00D04H1/55D04H1/559D04H1/728
Inventor 石锐池骋张静爽李伟阳田伟
Owner 北京市创伤骨科研究所
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