A hard capsule preparation

A technology of hard capsules and preparations, which is applied in capsule delivery, medical preparations containing non-active ingredients, and medical preparations containing active ingredients. Excellent stability and uniform drug content
CN107638403BActive Publication Date: 2020-05-05JIANGSU VCARE PHARMATECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU VCARE PHARMATECH
Publication Date
2020-05-05

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Abstract

The invention relates to a lubiprostone hard capsule preparation and a preparation method thereof, wherein the lubiprostone hard capsule preparation comprises a gelatin capsule shell, lubiprostone-containing particles, and a lubricant. According to the present invention, the lubiprostone hard capsule preparation has advantages of uniform drug content, excellent stability, rapid dissolution in vitro and simple operation, and is particularly suitable for the industrial production of solid preparation workshops.
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Description

Technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and particularly relates to a hard capsule preparation of lubiprostone and a preparation method thereof. Background technique

[0002] Lubiprostone is a selective chlorine channel activator. It has a novel mechanism of action. It can increase the secretion of intestinal juice and enhance intestinal peristalsis. It is beneficial to alleviate the symptoms of constipation. It has been approved by the FDA to treat adult chronic idiopathic constipation and adult chronic chronic constipation. Constipation caused by opioid use in non-cancerous pain patients and constipated irritable bowel syndrome in women over 18 years of age.

[0003] Because this product is easily degraded in water and has low stability, the commercially available product dissolves the drug in medium-chain triglycerides to make a soft capsule preparation. The preparation method has been disclosed by patent CN101410097A. Although ...

Claims

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