A kind of chitosan bone nail material with helical orientation structure and preparation method thereof

Abstract

The invention discloses a chitosan bone nail material with a spiral orientation structure and a preparation method thereof. The method comprises the following steps: preparing a chitosan solution by adopting a mechanical stirring method; performing wet spinning on the chitosan solution by utilizing an injection device with a duct; performing orientation stretching and sequential spiral winding collection on primary fiber by adopting a collecting device at adjustable rotating speed, thereby acquiring a chitosan fiber bar with a compact three-dimensional piling structure; washing the bar till pH=6-8 and then placing into a SBF (Simulated Body Fluid) for mineralizing; and cleaning and drying, thereby acquiring the chitosan bone nail. A medical chitosan bone nail prepared according to the invention has a height orientation structure and a self-threading function; the step of externally threading is avoided; the structure defects and the raw material waste brought by the process of externally threading are eliminated; the bone induction regeneration capacity of the bone nail is greatly promoted in the mineralizing process; the bone nail is expected to be applied to the field of bone regeneration and repairing.

Description

technical field

[0001] The invention belongs to the field of preparation of bone nail materials, and relates to a preparation method of chitosan bone nails, in particular to a chitosan bone nail material with a helical orientation structure and a preparation method thereof. Background technique

[0002] As a bone fixation device commonly used in the bone repair process, bone nails can be used to treat fractures, bone deformation and other diseases. Traditional bone nails are all made of metal and alloy materials, which have the advantages of high strength and good toughness. However, non-degradable metal materials also bring many problems to the treatment process: (1) metal materials cannot degrade in the human body, and the bone nails need to be removed through a second operation after bone healing, causing pain to the patient; (2) the rigidity is too high (3) In the case of physiological corrosion and wear, toxic metal ions will be produced, leading to inflammation. Ther...

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