Method for preparing novel valved vessels

Abstract

The invention relates to a method for preparing novel valved vessels. The method is characterized in that the novel valved vessel comprises a blood vessel pipe, valves and a connection; the valves areconnected to the blood vessel pipe through the connection. This method not only ensures the internal and external fixation of blood vessels, but also ensures the natural state of blood vessels whichare not folded and twisted, and is beneficial to surgical anastomosis, anti-calcification, anti-aging, and significantly improve the long-term results.

Description

technical field [0001] The invention relates to a blood vessel, in particular to a preparation method of a novel blood vessel with a valve, and belongs to the technical field of medical biomaterials. Background technique [0002] The incidence rate of congenital heart disease in my country is about 0.6-0.9%, ranking first in birth defects. There are about 150,000 to 200,000 new children with congenital heart disease every year, and more than 2 million existing children with congenital heart disease. Among them, complex congenital heart disease is about Accounted for 20%. A considerable number of complex congenital heart disease lesions involve the right ventricular outflow tract, such as severe tetralogy of Fallot, complete transposition of the great arteries, common arterial trunk, double outlet of the right ventricle, and pulmonary atresia. The perfection of the structure and function of the pulmonary valve is an important issue, which directly affects the long-term curati...

AI Technical Summary

Problems solved by technology

At present, it is believed that the main reasons for the calcification of biomaterials caused by glutaraldehyde cross-linking and immobilization are as follows: 1) After cross-linking, biomaterials lose a large amount of soluble protein, and the exposed amino acid aldehyde groups on the surface can induce the formation of calcium crystals, and make phosphoric acid, adenosine triphosphate, The effect of proteoglycan on inhibiting calcification is destroyed; 2) Glutaraldehyde cross-linking can destroy the normal calcium regulation mechanism of cells, causing calcium ions to accumulate in cells, and the fragments and lipids of dead cells can become the initial core of calcification; 3) There are still unpaired carboxyl groups after glutaraldehyde treatment. The carboxyl groups contained in amino acids in biomaterial collagen are most likely to combine with calcium salts. In addition, the cytotoxicity after glutaraldehyde treatment makes it difficult for vascular endothelial cells to grow and cover. Fiber exposure; 4) The cytotoxicity of free aldehyde groups of glutaraldehyde can also induce inflammatory cell chemotaxis, cause chronic inflammatory cell infiltration, and promote local calcium salt deposition

Those skilled in the art try to solve this technical problem, but this problem has not been well solved

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