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Application of hederagenin and its glucoside in preparation of medicine for inhibiting liver gluconeogenesis

A technology of hedera saponin and gluconeogenesis, which is applied in the field of medicine and can solve the problems of hedera saponin and its glycosides that have not yet been seen

Inactive Publication Date: 2018-03-02
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there is no report about the use of hedera saponin and its glycosides in inhibiting hepatic gluconeogenesis

Method used

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  • Application of hederagenin and its glucoside in preparation of medicine for inhibiting liver gluconeogenesis
  • Application of hederagenin and its glucoside in preparation of medicine for inhibiting liver gluconeogenesis
  • Application of hederagenin and its glucoside in preparation of medicine for inhibiting liver gluconeogenesis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1: The pharmacological action of helexin and its glycosides

[0043] 160 Kunming mice were randomly divided into 16 groups according to body weight and sex: the control group and the hedera saponin or saponin administration group with serial numbers 1-15. The mice in the treatment group were given 50 mg / kg / d helexin or saponin by intragastric administration respectively, and the mice in the control group were given an equal volume of solvent 0.5% CMC-Na by intragastric administration for 4 weeks, and after the last intragastric administration, they were fasted for 12 hours. , Tail vein blood was collected to measure fasting blood glucose, which was recorded as the blood glucose value at 0 min; thereafter, L-a-alanine was injected intraperitoneally at a dose of 2 g / kg body weight, and the eyeball was picked to take blood after 1 hour, and the blood glucose value was measured at 60 min. The gluconeogenesis rate (%) was calculated according to the blood glucose ...

Embodiment 2

[0048] Embodiment 2: Preparation and pharmacological action of an extract containing helexin or its glycosides

[0049] Part 1: Preparation of Extract

[0050] Preparation method one 5kg of dry Lonicera chinense medicinal material, reflux extraction with 70% ethanol for 3 times, 2h each time, filter, combine the filtrate, reclaim the solvent under reduced pressure to obtain extractum (get partly dried to obtain total extract 1), add appropriate amount of water to suspend , filter, and load the sample on D101 macroporous resin, start gradient elution from 10%, 30%, 50%, 70%, 90% ethanol, and monitor whether the eluate contains Decaisoside E, Honeysuckle saponin B or Dipsacus saponin B, any of the three appear in the eluent and start to collect until all three are eluted from the resin and stop collecting. Concentrate and dry this part of the eluent to obtain the extract of Lonicera tomentosa Object 1.

[0051] Preparation method two 5kg of dry Lonicera chinensis medicinal ...

Embodiment 3

[0065] Embodiment 3: pharmaceutical preparation

[0066] 1. Tablet: 5g of helexin or saponin or Lonicera tomentosa extract of serial number 1-15, 50g of starch, 3g of magnesium stearate. Preparation process: take the hedera saponin or saponin or the extract of Lonicera tomentosa with the serial number 1-15, add starch and magnesium stearate, mix evenly, make granules, dry, and compress into tablets.

[0067] 2. Capsules: 5g of hedera saponin or saponin or Lonicera tomentosa extract with serial number 1-15, 50g of starch, 3g of magnesium stearate. Preparation process: take the hedera saponin or saponin or Lonicera tomentosa extract of serial number 1-15, add starch and magnesium stearate, mix evenly, make granules, dry, and pack into capsules.

[0068] 3. Injection: 1g of hedera saponin or saponin or Lonicera tomentosa extract with serial number 1-15, appropriate amount of sodium chloride for injection. Preparation process: take the hedera saponin or saponin or Lonicera chrys...

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Abstract

The invention discloses an application of hederagenin and its glucoside in preparation of a medicine for inhibiting liver gluconeogenesis. The invention provides the application of the hederagenin with a sequence number being 1-15 or saponin in preparation of the medicine for inhibiting liver gluconeogenesis. The experiment result proves that the hederagenin with the sequence number being 1-15 orsaponin has obvious inhibition effect on gluconeogenesis of mice and has obvious promoting effect for synthesis of hepatic glycogen, so that the hederagenin with the sequence number being 1-15 or saponin has obvious effects for inhibiting liver gluconeogenesis. The technical staff of the filed fully believes that the hederagenin with the sequence number being 1-15 or saponin has good inhibiting effect for liver gluconeogenesis, and can be exploited to the medicines for treating diseases such as obesity, non-alcoholic fatty liver disease, and diabetes.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the new application of known natural products, in particular to the application of helexin and its glycosides in the preparation of drugs for inhibiting hepatic gluconeogenesis. Background technique [0002] Hederagenin is a pentacyclic triterpenoid compound with the chemical name (3β,4α)-3,23-dihydroxyolean-12-ene-28-acid, and the molecular formula is C 30 h 48 o 4 . Hedera saponin is a glycosidation product of hedera saponin. [0003] Hedera saponin and hedera saponin are abundant in natural resources, and are widely distributed in Disperaceae, Lonicaceae, Ranunculaceae, Araliaceae and Patrinaceae and other plants, and have good development advantages. The applicant has conducted systematic research on hederagenin and hedera saponin, and found that hedera saponin and hedera saponin have various pharmacological effects, have preventive value for various diseases, and have broad clinical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K31/704A61K31/7024A61P3/04A61P3/10A61P1/16
CPCA61K31/56A61K31/7024A61K31/704
Inventor 李萍刘群齐炼文
Owner CHINA PHARM UNIV
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