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A polyvinyl alcohol/hydroxyapatite composite scaffold

A technology of hydroxyapatite and polyvinyl alcohol, which is applied in the fields of medical science, prosthesis, coating, etc., can solve the problems of complicated preparation process, and achieve the effect of excellent sustained release performance and mechanical performance.

Active Publication Date: 2019-02-12
中国人民解放军总医院第八医学中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN101862230A discloses the preparation of isoniazid-rifampicin controlled-release drug-loaded artificial bone prepared by 3D printing technology. The preparation process is complicated, and there is still room for improvement in drug sustained-release and mechanical properties

Method used

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  • A polyvinyl alcohol/hydroxyapatite composite scaffold
  • A polyvinyl alcohol/hydroxyapatite composite scaffold
  • A polyvinyl alcohol/hydroxyapatite composite scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Preparation method of bioactive porous hydroxyapatite

[0030] Concentration is that 2.0% (g / mL) sodium alginate solution 200ml is added dropwise in the calcium chloride solution 10ml that concentration is 1mol / L through metering injection needle, the alginate gel microbead that obtains is fully After cross-linking, followed by three washes with deionized water to remove excess solution, the wet beads were immersed in ethanol for solvent exchange. Hydroxyapatite slurry was prepared by mixing 20 g of hydroxyapatite powder with 500 ml of sodium alginate solution with a concentration of 2% (g / mL). The solvent-exchanged beads and hydroxyapatite slurry were transferred to a cylindrical mold, and the mixture was then uniaxially compressed with a piston to fill the cavities in the beads with the hydroxyapatite slurry. At the same time, bridges are formed between the microbeads. Putting the slurry infiltration template into the calcium chloride solution to make the hydroxy...

Embodiment 2

[0041] The preparation method of bioactive porous hydroxyapatite and porous artificial bone scaffold material is the same as that of Example 1, except that the steps (2)-(5) of preparing porous artificial bone scaffold material are replaced by:

[0042] (2) 8g bioactive porous hydroxyapatite is put into the rifampin-polyvinyl alcohol solution;

[0043] (3) Vacuum suction under a negative pressure of 0.1Mpa until no obvious air bubbles seep out around the material, take out the material, and centrifuge at 1000r / min for 10 minutes to remove excess drug solution in the material to avoid clogging of the internal pores of the material, then take it out again Materials, placed in an electric dryer to dry for 5 hours;

[0044] (4) placing the material obtained in step (3) into the isoniazid-polyvinyl alcohol solution, and repeating step (3);

[0045] (5) placing the material obtained in step (4) into the rifampicin-polyvinyl alcohol solution, and repeating step (3);

[0046] (6) Pu...

Embodiment 3

[0048] The preparation method of bioactive porous hydroxyapatite and porous artificial bone scaffold material is the same as that of Example 1, except that the amount of rifampicin is replaced by 2 g.

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Abstract

A polyvinyl alcohol / hydroxyapatite composite stent adopts an active porous hydroxyapatite carrier as a core layer, and the surface of the carrier is alternately coated with four polyvinyl alcohol coatings, wherein the four polyvinyl alcohol coatings sequentially are one isoniazid-containing polyvinyl alcohol coating, one rifampin-containing polyvinyl alcohol coating, one isoniazid-containing polyvinyl alcohol coating and one rifampin-containing polyvinyl alcohol coating from inside to outside, or sequentially are one rifampin-containing polyvinyl alcohol coating, one isoniazid-containing polyvinyl alcohol coating, one rifampin-containing polyvinyl alcohol coating, one isoniazid-containing polyvinyl alcohol coating from inside to outside.

Description

technical field [0001] The invention relates to the technical field of medical artificial bone graft materials, in particular to a slow-release composite material for postoperative bone filling that can be used for anti-tuberculosis, and a preparation method thereof. Background technique [0002] Bone tuberculosis often comes from pulmonary tuberculosis, mainly including spinal tuberculosis and joint tuberculosis. Most patients come from poor families in developing countries such as India, China and southern Africa. The destruction and deformity of bone tissue, and the secondary nerve damage will seriously affect the life and treatment of patients, and cause a heavy economic burden. Patients with severe complications require surgical treatment, and debridement is the most critical surgical step. However, complete clearance of lesions is often difficult to achieve, resulting in recurrence of tuberculosis. [0003] Long-term oral anti-tuberculosis drugs are the principle fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/34A61L27/54A61L27/56
CPCA61L27/12A61L27/34A61L27/54A61L27/56A61L2300/216A61L2300/404A61L2300/602A61L2420/06A61L2420/08A61L2430/02C08L29/04
Inventor 崔旭翁杰
Owner 中国人民解放军总医院第八医学中心