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Compound pharmaceutical composition containing piperacillin and application thereof

A kind of technology of piperacillin and composition, applied in the field of pharmaceutical composition containing piperacillin

Active Publication Date: 2022-04-12
XIANGBEI WELMAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The combination of avibactam and other β-lactam antibiotics has not been reported

Method used

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  • Compound pharmaceutical composition containing piperacillin and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Piperacillin sodium 1000g, avibactam sodium 125g, pulverized under aseptic conditions (jet mill), mixed together uniformly (single cone ribbon mixer), sub-packaged to obtain piperacillin sodium avibactam Pharmaceutical composition of bactam sodium.

Embodiment 2

[0040] 1200 g of piperacillin sodium and 300 g of avibactam sodium were dissolved in water to form a solution, which was placed in a lyophilizer for lyophilization to obtain a pharmaceutical composition of piperacillin sodium and avibactam sodium.

Embodiment 3-9

[0042] According to the method of Example 1, multiple batches of piperacillin sodium and avibactam sodium pharmaceutical compositions with different ratios of active ingredients were prepared. In embodiment 3-9, the consumption of piperacillin sodium and avibactam sodium is respectively successively: 900g and 450g, 700g and 700g, 500g and 600g, 300g and 600g, 200g and 1000g, 200g and 1440g, and 100g and 900g.

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PUM

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Abstract

The invention provides a compound pharmaceutical composition containing piperacillin and its application. In the compound pharmaceutical composition, piperacillin and avibactam are used as active ingredients, and both piperacillin and avibactam are in solid form exist. The pharmaceutical composition of the present invention has excellent antibacterial activity, especially has good effect on drug-resistant Streptococcus pneumoniae, and improves the efficacy by dozens of times compared with the existing piperacillin product.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing piperacillin. The present invention also relates to the application of the pharmaceutical composition in medicine. Background technique [0002] Piperacillin is a penicillin antibiotic commonly used in clinical practice, and its sodium salt is the main medicinal form. Piperacillin sodium can be used to treat sepsis caused by Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter, etc., upper urinary tract and complicated urinary tract infections, respiratory tract infections, biliary tract infections, abdominal infections, pelvic infections and Skin, soft tissue infections, etc., are widely used clinically. However, after years of use, many pathogenic bacteria have developed resistance to piperacillin. In order to solve the problem of drug resistance, people have developed a compound preparation of piperacillin, which uses a β-lactamase inhibitor and piperacillin to form a prescript...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K31/439A61P31/04
CPCA61K31/439A61K31/496A61K2300/00
Inventor 不公告发明人
Owner XIANGBEI WELMAN PHARMA CO LTD
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