Compound nicotine salt and preparation method thereof

A technology of nicotine salt and nicotine is applied in the field of nicotine salt to achieve the effects of boosting spirit, soft and smooth inhalation, and sweet and comfortable taste of smoke

Inactive Publication Date: 2018-03-20
东莞济信生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the above problems in the prior art, the present invention provides a method for preparing a compound nicotine salt. The compound nicotine salt prepared by the method has good stability, the content is not easy to decay, and the color is ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method of compound nicotine salt, comprising the steps of:

[0038] (1) Add 0.9g of citric acid, 0.2g of lactic acid, 0.1g of lauric acid, 1g of glucose, 1.36g of propylene glycol and 5.44g of glycerin into a glass beaker, mix evenly, place the glass beaker on a constant temperature heater, and start to heat up to Keep heating at a constant temperature after 55°C, start stirring for 23 minutes from the time of heating, stop heating after fully dissolving, and obtain an organic acid solution, which contains sugar and ester at the same time;

[0039] (2) After the organic acid solution is cooled to normal temperature, 1 g of nicotine is added to the organic acid solution;

[0040] (3) After the nicotine and the organic acid solution are mixed, the mixed solution becomes turbid and self-heating, and begins to fully react. After 3.2 hours, the mixed solution stops reacting and is cooled to normal temperature. At this time, the solution appears as a clear yello...

Embodiment 2

[0041] A preparation method of compound nicotine salt, comprising the steps of:

[0042] (1) Add 6g of citric acid, 5.5g of malic acid, 5.2g of oxalic acid, 2g of succinic acid, 1.8g of gluconic acid, 1.5g of fructose acid, 2g of glucose, 28g of propylene glycol and 28g of glycerin into a glass beaker, mix well, and put the glass Place the beaker on a constant temperature heater, start to heat up to 60°C, and then keep heating at a constant temperature. Stir for 25 minutes from the time of heating to fully dissolve and then stop heating to obtain an organic acid solution. The organic acid solution contains sugar and ester at the same time;

[0043](2) After the organic acid solution is cooled to normal temperature, 20 g of nicotine is added to the organic acid solution;

[0044] (3) After the nicotine and the organic acid solution are mixed, the mixed solution appears turbid and self-heating, and begins to fully react. After 3.5 hours, the mixed solution stops reacting and is ...

Embodiment 3

[0046] A preparation method of compound nicotine salt, comprising the steps of:

[0047] 1) Add 6.8g of citric acid, 6.2g of malic acid, 5.9g of oxalic acid, 2.7g of isovaleric acid, 2.3g of benzoic acid, 2.1g of myristic acid, 4g of fructose, 32.2g of propylene glycol and 13.8g of glycerin into a glass beaker, and carry out Mix evenly, place the glass beaker on a constant temperature heater, start heating to 65°C and keep heating at a constant temperature, start stirring for 27 minutes from the time of heating, stop heating after fully dissolving, and obtain an organic acid solution, which contains sugar at the same time and esters;

[0048] (2) After the organic acid solution is cooled to normal temperature, 24 g of nicotine is added to the organic acid solution;

[0049] (3) After the nicotine is mixed with the organic acid solution, the mixed solution becomes turbid and self-heating, and begins to fully react. After 3.7 hours, the mixed solution stops reacting and is cool...

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PUM

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Abstract

The invention discloses compound nicotine salt and a preparation method thereof. The preparation method comprises the following steps: (1) uniformly mixing organic acid, sugar, propylene glycol and glycerin, carrying out constant temperature heating, and stirring for dissolving, so as to obtain an organic acid solution; (2) after the organic acid solution is cooled to the room temperature, addingnicotine into the organic acid solution; and (3) reacting by virtue of nicotine and the organic acid solution, and after the reaction is finished, cooling, so as to obtain the compound nicotine salt.The compound nicotine salt prepared by virtue of the preparation method is good in stability and relatively stable in color, and the content is unlikely to be decreased; and by utilizing the compoundnicotine salt, the acidity and sugar degree in a product can be increased, nicotine can be neutralized, the phenomena of piquancy and throat choking during the smoking of the product are reduced, andthe product becomes sweet and comfortable.

Description

technical field [0001] The invention belongs to the technical field of nicotine salts, and in particular relates to a compound nicotine salt and a preparation method thereof. Background technique [0002] Nicotine, also known as nicotine, is a neurotoxic agent. The mechanism of toxicity is mainly the N-choline response system to the central nervous system and cholinergic nerves. There will be a burning sensation and a local irritation to the digestive tract. [0003] Nicotine salts are characterized by the interaction between nicotine in ionic form and the coform (e.g., acid) in ionic form via the transfer of one or more protons from the coformer donor to the nicotine acceptor Nicotine form. The structure of nicotine is such that it contains two nitrogen atoms capable of accepting protons from the conformant, and therefore, it can exist in a given sample in non-protonated, monoprotonated and / or diprotonated forms. [0004] In tobacco, nicotine mostly exists in the form of...

Claims

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Application Information

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IPC IPC(8): A61K31/465A61K47/12A61K47/26A61K47/10A61P25/28A61P25/16A61P37/04A61P25/26A24B15/16A24B15/38A24F47/00A23G4/12
CPCA23G4/12A24B15/167A24B15/38A24F47/00A61K31/465A61K47/10A61K47/12A61K47/26
Inventor 张伟滨
Owner 东莞济信生物科技有限公司
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