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Method for producing injection type preparation for 3D printed artificial bone

A 3D printing and injection technology, applied in the medical field, can solve the problems of unsuitable storage, a single type of slow-release drug, and the inability to use multiple drugs in combination, so as to achieve the effect of controllable dosage

Pending Publication Date: 2018-03-23
河北点云生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The embodiment of the present application provides a method for manufacturing injection-type preparations by 3D printing artificial bone, which solves the problems in the prior art that the slow-release drugs currently in clinical use are only a single type, and cannot be used in combination with multiple drugs, and are not suitable for storage. , to achieve the technical effect of taking at any time, controllable dosage, convenient and hygienic

Method used

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  • Method for producing injection type preparation for 3D printed artificial bone
  • Method for producing injection type preparation for 3D printed artificial bone
  • Method for producing injection type preparation for 3D printed artificial bone

Examples

Experimental program
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Embodiment 1

[0031] figure 1 It is a schematic flowchart of a manufacturing method of 3D printing artificial bone provided in the embodiment of the present application. Such as figure 1 As shown, the method includes:

[0032] Step 110: dissolving the 0.1%-20% by weight copolymer containing lactic acid acetic acid into a solvent with 1,4-dioxane;

[0033] Step 120: Dissolving the first sensitive drug in the solvent to make a first suspension;

[0034] Specifically, the sensitive drug refers to the drug required for long-term sustained-release treatment of the target object during the treatment of osteomyelitis. Among them, according to the level of drug sensitivity, it can be divided into the first sensitive drug, the second sensitive drug, and the third sensitive drug, wherein, according to the degree of sensitivity to the target object, it can be defined as: the first sensitive drug The sensitivity is lower than the second sensitive drug, and the sensitivity of the second sensitive dr...

Embodiment 2

[0048] In order to realize the use of more moderately sensitive drugs and further improve the sustained-release effect, the embodiment of the present application also provides a method for manufacturing injection-type preparations by 3D printing artificial bones, such as figure 2 As shown, the method includes:

[0049] Step 210: adding the first paste material into a biological 3D printer for printing to form an inner layer;

[0050] Specifically, the first paste material that meets the input requirements of the biological 3D printer is added to the biological 3D printer for 3D printing. Since the 3D printing technology already belongs to the basic technology, the embodiment of the present application will not elaborate on the printing process and details of the 3D printer. method. It should be noted that the structure printed by the above 3D printer should match the bone defect required by the target object. That is to say, through the personalized characteristics of 3D pri...

Embodiment 3

[0065] In order to realize the use of more sensitive drugs and further improve the sustained-release effect, the embodiment of this application also provides a method for manufacturing injection-type preparations by 3D printing artificial bone, please refer to image 3 , the method includes:

[0066] Step 310: dissolving the fifth sensitive drug in the solvent, and making a fifth suspension;

[0067] Step 320: After adding the first solid substance into the fifth suspension, add the calcium-containing compound with a weight percentage of 5%-50% to form a third solid substance.

[0068] Step 330: dissolving the sixth sensitive drug in the solvent, and making a sixth suspension;

[0069] Step 340: After adding the third solid substance into the sixth suspension, add the calcium-containing compound with a weight percentage of 5%-50% to form a fourth solid substance.

[0070] Step 350: After adding the fourth solid matter into the second suspension, add a calcium-containing comp...

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Abstract

An embodiment of the invention provides a method for producing an injection type preparation for 3D printed artificial bone and relates to the technical field of medicine. The method comprises the steps as follows: a lactic acid-acetic acid containing copolymer with the weight percentage being 0.1%-20% is dissolved with 1,4-dioxane into a solvent; a first sensitive drug is dissolved in the solventand a first suspension is prepared; a first solid is prepared; a second sensitive drug is dissolved and a second suspension is prepared; a first pasty material is prepared after the first solid is added; the first pasty material is subjected to freeze drying to form a first preparation intermediate; then, the first preparation intermediate is mixed with a suspension of hydroxyapatite, the obtained mixture is placed in a syringe and the injection type preparation is formed. The problems that clinically applied slow release drugs are of the single kind, combined use of multiple drugs cannot berealized and the drugs are not easy to store in the prior art are solved, and the technical effects that multiple different drugs can be carried simultaneously and taken when used, the dosage is controllable and the injection type preparation is convenient and sanitary are realized.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for manufacturing injection-type preparations by 3D printing artificial bones. Background technique [0002] Osteomyelitis is an infection and destruction of bone caused by aerobic or anaerobic bacteria, mycobacteria and fungi. In the treatment of osteomyelitis, it is often necessary to penetrate the bone injury site and fill it with bone cement and other substances. [0003] However, in the process of realizing the technical solution of the invention in the embodiment of the present application, the inventor of the present application found that the above-mentioned technology has at least the following technical problems: [0004] In the prior art, in the clinical treatment of osteomyelitis, bone cement is used as a carrier or support to use slow-release drugs, but the above-mentioned scheme cannot be used in combination with multiple drugs because the slow-release dr...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/18A61L27/50A61L27/54B33Y10/00B33Y50/00B33Y70/00B33Y80/00
CPCA61L27/12A61L27/18A61L27/50A61L27/54A61L2300/406A61L2300/45A61L2300/602A61L2400/06A61L2430/02B33Y10/00B33Y50/00B33Y70/00B33Y80/00C08L67/04
Inventor 李征宇曾庆丰
Owner 河北点云生物科技有限公司
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