Pyrolidone hydrochloride drip pill and its preparation method

A technology of pioglitazone hydrochloride and pioglitazone dropping pills, applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the bioavailability of the first-pass effect of the liver and intestines, which is not conducive to improving the ability of patients to seek medical treatment, and is not conducive to the overall health level and other issues, to achieve the effects that are conducive to labor protection and environmental protection, improve bioavailability, and drug safety

Active Publication Date: 2005-10-26
盐城市大丰区生产力促进中心
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AI Technical Summary

Problems solved by technology

[0007] Due to preparation technology and other reasons, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the efficacy of the drug. , also directly affects the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the prepara

Method used

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  • Pyrolidone hydrochloride drip pill and its preparation method
  • Pyrolidone hydrochloride drip pill and its preparation method

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Embodiment Construction

[0032] Now with several groups of specific examples, the preparation method of pioglitazone hydrochloride dropping pills of the present invention will be further described.

[0033] [Group 1: Trials with a single substrate]

[0034] 1. Pioglitazone hydrochloride

[0035] [English name]Pioglitazonehydrochloride

[0036] [Chemical name] (±)-5-[[4-[2-(5-Ethyl-2-pyridyl)dioxy]benzyl]-2,4]thiazolidinedione hydrochloride.

[0037] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;

[0038] 3. Proportion: take g or kg as unit, by weight, pioglitazone hydrochloride: substrate = 1:1~1:9;

[0039] 4. Prepare according to the process given in [Preparation Method] 4-7 ​​to obtain pioglitazone hydrochloride dropping pills of different specifications.

[0040] [tes...

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Abstract

A dripping pill of bigelietong hydrochloride for treating diabetes is prepared from the bigelietong hydrochloride and the pharmacologically acceptable carrier.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating diabetes, in particular to a pharmaceutical composition oral preparation prepared from pioglitazone hydrochloride as a raw material. Background technique [0002] Type II diabetes mellitus (NIDDM) is the third largest disease in the world - the most common type of diabetes. Its main cause is insulin resistance, so long-term use of insulin therapy is not suitable, and the adverse reactions of sulfonylureas and biguanides are more obvious. Patients are not easy to accept. A class of hypoglycemic drugs developed in recent years that do not stimulate insulin secretion and act by enhancing the sensitivity of target tissues to insulin are thiazolidinedione derivatives, mainly including pioglitazone, troglitazone, Ciglitazone, englitazone, etc. can improve insulin resistance in patients, correct glucose and lipid metabolism disorders, and directly improve the toxicity of high glucose. This t...

Claims

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Application Information

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IPC IPC(8): A61K31/4436
Inventor 曲韵智徐俊福
Owner 盐城市大丰区生产力促进中心
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