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Acaudina molpadioidea active peptide with blood glucose reducing activity

A Haitian melon and hypoglycemic technology, applied in the field of Haitian melon active peptides, can solve problems such as lack of deep processing, and achieve the effects of low cost, good controllability, easy operation and implementation

Active Publication Date: 2018-04-03
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the development of Haitian melon is simply used as food, lack of deep processing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Crush 100g of dried Haitian melon, add water to make a suspension, wherein the mass ratio of Haitian melon to water is 1:6; then add 2% trypsin and papain compound enzyme (1:1) for enzymatic hydrolysis, the enzymatic hydrolysis process A magnetic stirrer was used in the medium, the enzymolysis time was 4 hours, the temperature was 50°C, and the pH value was 7; after the enzymolysis, ethanol was added to precipitate the polysaccharide, and the supernatant was collected after centrifugation at 8000rpm for 20min, and the supernatant was filtered through 1000Da and 360Da membranes , collect the concentrated solution with a molecular weight of 360-1000, decolorize the concentrated solution with activated carbon, remove fishy smell, and spray dry to obtain 10.65g of Haitian melon polypeptide. Through multiple screening and evaluation methods such as α-amylase inhibitor screening model, α-glucosidase inhibitor screening model, DPP4 inhibitor screening model, and insulin secreti...

Embodiment 2

[0022] Crush 100g of dried Haitian melon, add water to make a suspension, wherein the mass ratio of Haitian melon to water is 1:6; then add 2% trypsin and papain (3:2) for enzymatic hydrolysis, the enzymatic hydrolysis process Use a magnetic stirrer in the medium, enzymolysis time 2h, temperature 50°C, pH value 7; after enzymolysis, add ethanol to precipitate polysaccharides, centrifuge at 8000rpm for 20min, take the supernatant, and filter the supernatant through 1000Da and 360Da membranes , collect the concentrated solution with a molecular weight of 360-1000, decolorize the concentrated solution with activated carbon, remove fishy smell, and spray dry to obtain 13.5g of Haitian melon polypeptide. Through multiple screening and evaluation methods such as α-amylase inhibitor screening model, α-glucosidase inhibitor screening model, DPP4 inhibitor screening model, and insulin secretion model of islet cells after high-glucose injury, the combination of trypsin and papain was det...

Embodiment 3

[0024] Crush 100g of dried Haitian melon, add water to make a suspension, wherein the mass ratio of Haitian melon to water is 1:6; then add 4% trypsin and papain compound enzyme (3:1) for enzymatic hydrolysis, the enzymatic hydrolysis process Use a magnetic stirrer in the medium, enzymolysis time 2h, temperature 50°C, pH value 7; after enzymolysis, add ethanol to precipitate polysaccharides, centrifuge at 8000rpm for 20min, take the supernatant, and filter the supernatant through 1000Da and 360Da membranes , collect the concentrated solution with a molecular weight of 360-1000, decolorize the concentrated solution with activated carbon, remove the smell, and spray dry to obtain 17.8g of Haitian melon polypeptide. Through multiple screening and evaluation methods such as α-amylase inhibitor screening model, α-glucosidase inhibitor screening model, DPP4 inhibitor screening model, and insulin secretion model of islet cells after high-glucose injury, the combination of trypsin and ...

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PUM

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Abstract

The invention provides an acaudina molpadioidea active peptide with blood glucose reducing activity. According to a method for preparing an oral solution from an acaudina molpadioidea blood glucose reducing peptide, acaudina molpadioidea is used as a raw material, and the acaudina molpadioidea active peptide can be prepared from the acaudina molpadioidea, so that the method is low in cost, green and environmentally friendly; oral application of the acaudina molpadioidea active peptide can assist in reduction of blood glucose, and the acaudina molpadioidea active peptide has an effect of assisting in reducing blood glucose; and the oral solution can be prepared from the acaudina molpadioidea blood glucose reducing peptide serving as an effective component, and has a good market prospect. The method for preparing the oral solution from the acaudina molpadioidea blood glucose reducing peptide is easy for preparation, high in controllability, easy to operate and implement and favorable forindustrial large-scale production, and has a wide application prospect and good economical benefits.

Description

technical field [0001] The invention belongs to the technical field of active substance development, and in particular relates to a Haitian melon active peptide with hypoglycemic activity and application thereof. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to insulin secretion defect or insulin action disorder, mainly manifested as polydipsia, polydipsia, polyuria, polyphagia, fatigue, weight loss and other symptoms. Sustained high blood sugar and long-term metabolic disorders can lead to damage, dysfunction and failure of tissues and organs throughout the body, especially the eyes, kidneys, cardiovascular and nervous systems. At present, there are many hypoglycemic drugs approved for marketing, but all of them have strong side effects. Therefore, oral administration of food-derived oral liquids with hypoglycemic effect is a very effective method. [0003] Haitian melons are abundant in subtropical sandy sea area...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P21/06C07K1/34A23L33/18A23L33/00
CPCA23V2002/00A23L33/00A23L33/18C12P21/06A23V2200/328A23V2250/55
Inventor 邸多隆王宁丽裴栋魏鉴腾
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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