A kind of solid lipid nanoparticle and preparation method thereof
A technology of solid lipid nano and lipid materials, applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problem of reducing the order of lipid lattice, reducing the crystallinity of lipids, long-term storage or heating Hydrolysis and other problems to achieve the effect of reducing particle aggregation and growth, reducing lipid crystallinity, and improving storage stability
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Embodiment (1
[0031] Accurately weigh 100 mg of glyceryl behenate (Compritol 888 ATO), put it in a water bath at 80° C. and melt it as the oil phase. Accurately weigh N at the same time, N, N-trimethyl-N-octyl chitosan (TOC, molecular weight 50,000, degree of deacetylation is greater than 85%, degree of substitution of alkylation 0.61, degree of substitution of trimethylation 37 %) 100 mg, dissolved in water, as the water phase, heated to the same temperature, the water phase was added to the oil phase, and a high-speed disperser was used at 11,000 rpm for 3 min to form colostrum. The prepared colostrum was ultrasonicated at 600W for 6 minutes, and cooled to room temperature to obtain solid lipid nanoparticles. Store at 25°C for 6 months, and measure the particle size and Zeta of the solid lipid nanoparticles with a particle size potential analyzer (Nano ZS 90, Malvern, UK) at 0 month, 3 months, and 6 months, respectively. potential, the results are shown in Table 1. From the data of grou...
Embodiment (2
[0033] Accurately weigh 100 mg of glyceryl behenate (Compritol 888 ATO), put it in a water bath at 80° C. and melt it as the oil phase. Accurately weigh N at the same time, N, N-trimethyl-N-octyl chitosan (TOC, molecular weight 50,000, degree of deacetylation is greater than 85%, degree of substitution of alkylation 0.61, degree of substitution of trimethylation 37 %) 100 mg, dissolved in water, as the water phase, heated to the same temperature, the water phase was added to the oil phase, and a high-speed disperser was used at 11,000 rpm for 3 min to form colostrum. The prepared colostrum high-pressure homogenizer is circulated at 10 to 500 psi three times, and cooled to room temperature to obtain solid lipid nanoparticles. Stored at 25°C for 6 months, and measured the particle size and Zeta potential of the solid lipid nanoparticles at 0 month, 3 months, and 6 months, respectively, the results are shown in Table 1. From the data of group 2 in Table 1, it can be seen that th...
Embodiment (3
[0035] 100 mg of glyceryl monostearate were accurately weighed, and melted in a water bath at 80° C. as the oil phase. At the same time, N, N, N-trimethyl-N-octyl chitosan (TOC, molecular weight 100,000, deacetylation degree greater than 85%, alkylation degree of substitution 0.51, trimethylation degree of substitution 31 %) 100mg, dissolved in water, as the water phase, after being heated to the same temperature, the water phase was added to the oil phase, and the colostrum was formed by using a high-speed disperser at 11000 rpm for high-speed shearing and high-speed shearing for 2min. Add the prepared colostrum into a high-pressure homogenizer at 7 500 psi to circulate twice, and cool to room temperature to obtain solid lipid nanoparticles. Stored at 25°C for 6 months, and measured the particle size and Zeta potential of the solid lipid nanoparticles at 0 month, 3 months, and 6 months, respectively, the results are shown in Table 1. From the data of group 3 in Table 1, it c...
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