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Magnesium alloy stent for loading medical/genic nanometer particles and preparation method thereof

A magnesium alloy stent, magnesium alloy technology, applied in drug delivery, pharmaceutical formulation, medical science, etc., can solve problems such as inability to degrade in vivo

Inactive Publication Date: 2018-04-06
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to provide a magnesium alloy stent loaded with drugs / gene nanoparticles and its preparation method, which solves the problem that currently commonly used DES are mostly permanent stents, and the carrier materials are mostly stainless steel, nickel-titanium alloy and cobalt-titanium alloy, etc. , the problem of not being able to degrade in the body

Method used

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preparation example Construction

[0014] The invention provides a method for preparing a magnesium alloy stent loaded with drugs / gene nanoparticles, the preparation method comprising:

[0015] (1) Mix ethanol and silane coupling agent to prepare coupling agent mixture;

[0016] (2) Dip the magnesium alloy test piece into the coupling agent mixture to obtain the modified magnesium alloy test piece;

[0017] (3) Immerse the modified magnesium alloy test piece in the everolimus / chitosan solution, and dry to obtain the magnesium alloy scaffold loaded with drug nanoparticles; or

[0018] The modified magnesium alloy test piece was immersed in the microRNA-130a / chitosan solution, dried to obtain a magnesium alloy scaffold loaded with gene nanoparticles.

[0019] In a preferred embodiment of the present invention, in order to further improve the biodegradability of the prepared magnesium alloy stent and its drug or gene efficacy, the volume fraction of the coupling agent mixture is 4-6%.

[0020] In a preferred emb...

Embodiment 1

[0034] Mix ethanol and silane coupling agent for 8 seconds to obtain a coupling agent mixture (volume fraction 4%); the magnesium alloy test piece (the magnesium alloy test piece needs to be polished from 800 mesh to 2000 mesh with metallographic sandpaper, and then use acetone and absolute ethanol to remove surface oil stains, then ultrasonically cleaned in deionized water, and dried for later use) immersed in the coupling agent mixture to obtain a modified magnesium alloy test piece; the modified magnesium alloy test piece was immersed in everolimus / In a chitosan solution (obtained by mixing 0.1 mg / mL everolimus solution and 1 mg / mL chitosan solution at a volume ratio of 0.8:10), vertically pull at a constant speed of 4 cm / min The modified magnesium alloy test piece was pulled for 3 times and dried (at a temperature of 35°C for 22 hours) to obtain a magnesium alloy scaffold loaded with drug nanoparticles; the modified magnesium alloy test piece was immersed in microRNA-130a / ...

Embodiment 2

[0036]Mix ethanol and silane coupling agent for 12s to obtain a coupling agent mixture (volume fraction 6%); the magnesium alloy test piece (the magnesium alloy test piece needs to be polished from 800 mesh to 2000 mesh with metallographic sandpaper, and then use acetone and absolute ethanol to remove surface oil stains, then ultrasonically cleaned in deionized water, and dried for later use) immersed in the coupling agent mixture to obtain a modified magnesium alloy test piece; the modified magnesium alloy test piece was immersed in everolimus / In a chitosan solution (obtained by mixing 0.1 mg / mL everolimus solution and 1 mg / mL chitosan solution at a ratio of 1.2:10 by volume), pull vertically at a constant speed of 6 cm / min The modified magnesium alloy test piece was pulled 5 times and dried (at a temperature of 45°C for 26 hours) to obtain a magnesium alloy scaffold loaded with drug nanoparticles; the modified magnesium alloy test piece was immersed in microRNA-130a / In the...

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Abstract

The invention discloses a magnesium alloy stent for loading medical / genic nanometer particles and a preparation method thereof. The preparation method includes the steps of blending ethyl alcohol witha silane coupling agent to prepare a coupling agent mixed liquid; soaking a magnesium alloy testing sheet into the coupling agent mixed liquid to obtain a modified magnesium alloy testing sheet; soaking the modified magnesium alloy testing sheet into everolimus / chitosan liquid, and drying the sheet to obtain the magnesium alloy stent for loading the medical nanometer particles; or soaking the modified magnesium alloy testing sheet into micro RNA-130a / chitosan liquid, and then drying the sheet to obtain the magnesium alloy stent for loading the genic nanometer particles. The magnesium alloy stent for loading the medical / genic nanometer particles solves the problems that since DES frequently used nowadays usually is a permanent stent, carrier materials often are stainless steel, nitinol alloy, titanium alloy and the like which cannot be degraded in the human body. Meanwhile, by loading the medical / genic nanometer particles, the prepared magnesium alloy stent can reduce the risk that thrombi are formed since the interior of a stent body is too narrow.

Description

technical field [0001] The invention relates to a magnesium alloy stent, in particular to a magnesium alloy stent loaded with drug / gene nanoparticles and a preparation method thereof. Background technique [0002] Coronary heart disease, namely coronary atherosclerotic heart disease, is the most common cardiovascular disease with acute onset and high mortality. The main symptoms are plaques after coronary atherosclerosis, resulting in vascular stenosis, acute thrombosis after plaque rupture, accompanied by coronary artery spasm, which leads to a sharp reduction or suspension of coronary blood flow, and ultimately leads to myocardial insufficiency. Percutaneous coronary stenting is an important means of treatment of coronary artery disease. At present, most of the commonly used DES are permanent stents, and the carrier materials are mostly stainless steel, nickel-titanium alloy, and cobalt-titanium alloy, which cannot be degraded in vivo. After the surface drug coating is e...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/08A61L31/02A61L31/14A61L31/16
CPCA61L31/022A61L31/08A61L31/10A61L31/148A61L31/16A61L2300/204A61L2300/236A61L2300/258A61L2300/41A61L2300/416A61L2300/42A61L2300/602A61L2300/606A61L2400/12A61L2400/18A61L2420/06C08L5/08
Inventor 宋春莉
Owner JILIN UNIV
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