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A kind of nanoscale enteral nutrition preparation and preparation method thereof

An enteral nutrition preparation, nano-scale technology, applied in the function of food ingredients, vitamin-containing food ingredients, oligosaccharide-containing food ingredients, etc., can solve the protection of mixed peptides or multi-component small peptides. Nutrients do not have relatively extensive and effective practical application and other problems, and achieve the effect of promoting comprehensive development and utilization, improving the scope of practical application and high cost performance.

Inactive Publication Date: 2021-07-13
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few reports on the entrapment protection of mixed peptides or multi-component small peptides
At the same time, the application of nanotechnology in food is mostly limited to the application of packaging, but there is no extensive and effective practical application of nutrients themselves.

Method used

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  • A kind of nanoscale enteral nutrition preparation and preparation method thereof
  • A kind of nanoscale enteral nutrition preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Step 1: Take 50mL of PBS buffer solution, add 60mg of egg yolk lecithin, 5mL of chloroform, stir for 5min, rotate evaporate at 30°C for 8min, dry in a drying oven at 40°C for 30min, add 40mL of PBS buffer solution and stir evenly Finally, add 420 mg of egg white-derived small peptides and 240 mg of soybean-derived small peptides, stir evenly and then sonicate for 15 minutes to obtain a small peptide liposome nanoparticle solution with an embedding rate of 87% and a particle size of 85 nm;

[0024] Step 2: Add 135 mg medium-chain triglycerides and 70 mg olive oil to the small peptide liposome nanoparticle solution prepared in step 1, and ultrasonicate for 10 minutes to obtain medium-chain triglycerides in a water-oil-water system with a particle size of 162 nm. Ester+olive oil / small peptide liposome nanoparticle solution, spray-dried to obtain the desired sample;

[0025] Step 3: Take 50% of the sample obtained by spray drying in Step 2, mix it with 0.5% multivitamins, 1...

Embodiment 2

[0032] Step 1. Take 100mL of PBS buffer solution, add 100mg of soybean lecithin, 12mL of chloroform, stir for 7 minutes, and rotate at 35°C for 5 minutes, dry in a drying oven at 40°C for 35 minutes, add 65mL of PBS buffer solution and stir evenly Finally, add 560 mg of egg white-derived small peptides and 440 mg of soybean-derived small peptides, stir evenly and then sonicate for 10 minutes to obtain a small peptide liposome nanoparticle solution with an embedding rate of 91% and a particle size of 90 nm;

[0033] Step 2: Add 160 mg medium-chain triglycerides and 85 mg olive oil to the small peptide liposome nanoparticle solution prepared in step 1, and ultrasonicate for 13 minutes to obtain medium-chain triglycerides in a water-oil-water system with a particle size of 175 nm. Ester+olive oil / small peptide liposome nanoparticle solution, spray-dried to obtain the desired sample;

[0034] Step 3: Take 55% of the sample obtained by spray drying in Step 2, mix it with 0.7% multivi...

Embodiment 3

[0041] Step 1: Take 150mL of PBS buffer solution, add 130mg of egg yolk lecithin, 13.5mL of chloroform, stir for 4 minutes, and rotate at 35°C for 10 minutes, dry in a drying oven at 42°C for 35 minutes, add 70mL of PBS buffer solution and stir After uniformity, add 650 mg of small peptides derived from egg white and 520 mg of small peptides derived from soybeans, stir well and then sonicate for 18 minutes to obtain a small peptide liposome nanoparticle solution with an embedding rate of 89% and a particle size of 82 nm;

[0042] Step 2: Add 185 mg of medium-chain triglycerides and 13 mg of olive oil to the small peptide liposome nanoparticle solution prepared in step 1, and sonicate for 13 minutes to obtain medium-chain triglycerides in a water-oil-water system with a particle size of 152 nm. Ester+olive oil / small peptide liposome nanoparticle solution, spray-dried to obtain the desired sample;

[0043] Step 3: Take 48% of the sample obtained by spray drying in Step 2, mix it...

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Abstract

The invention discloses a nanoscale enteral nutritional preparation and a preparation method thereof. The nutritional preparation includes egg white-derived small peptides, soybean-derived small peptides, maltodextrin, medium-chain triglycerides, olive oil, prebiotics, multivitamins, Total dietary fiber, minerals and lecithin, the contents of various raw materials by mass percentage are: egg white-derived small peptides 15-25%, soybean-derived small peptides 10%-15%, maltodextrin 20-35%, medium-chain glycerol Triesters 5‑10%, Olive Oil 2‑5%, Prebiotics 1‑3%, Multivitamins 0.2‑1%, Total Dietary Fiber 5‑10%, Minerals 3‑6% and Lecithin 3‑7%. The preparation method is as follows: step 1, preparation of small peptide liposome nanoparticles; step 2, preparation of composite small peptide liposome nanoparticles; The nanoscale enteral nutrition preparation is prepared by spray-drying the peptide liposome nanoparticle solution. Beneficial effects: the related process effectively removes the organic solvent used in the process, and is safe, stable and efficient.

Description

technical field [0001] The invention relates to an enteral nutrition preparation and a preparation method thereof, in particular to a nanoscale enteral nutrition preparation and a preparation method thereof. Background technique [0002] At present, enteral nutrition is an important method of clinical nutritional support treatment, and it is also an important way to effectively supplement nutrients that are relatively deficient in daily food. Enteral nutrition adapts to the digestion and absorption of the human body, and the metabolic mode is more in line with physiology, which helps to maintain the integrity of the intestinal mucosa structure and function, promotes the recovery of the body, promotes the repair of the digestive tract mucosa, maintains the intestinal mucosal barrier, reduces microbial infections, It plays an important role in promoting the secretion of related substances, strengthening metabolism and reducing the occurrence of related diseases. [0003] Mode...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/18A23L33/125A23L33/115A23L33/15A23L33/155A23L33/21A23L33/16A23L33/10
CPCA23V2002/00A23L33/10A23L33/115A23L33/125A23L33/15A23L33/155A23L33/16A23L33/18A23L33/21A23V2200/30A23V2250/55A23V2250/5114A23V2250/1944A23V2250/28A23V2250/511A23V2250/708A23V2250/71A23V2250/712A23V2250/7056A23V2250/5116A23V2250/5118A23V2250/1842A23V2250/1578A23V2250/161A23V2250/1642A23V2250/1592
Inventor 刘静波杜志阳谭大伟丁龙张婷
Owner JILIN UNIV
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