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Preoperative corneal irrigation solution, preparation method and application thereof

A flushing solution and cornea technology, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of irritation in the eye, disinfection of the cornea, and eye cleaning Insufficient and other problems, to achieve the effect of promoting mydriasis, facilitating the identification of lesion sites, and increasing absorption

Active Publication Date: 2020-09-25
湖北远大天天明制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, eye preparations generally include drops for daily use and drops for surgery, and drops for surgery are more researched on drops during surgery, and less research is done on drops before surgery. At the same time, existing pre-operative drops For eye cleaning, normal saline is generally used to clean the cornea, but the use of normal saline to rinse the eyes has a high osmotic pressure, which is irritating to the eye and cannot effectively disinfect the cornea, which in turn leads to eye damage. Insufficient cleansing of the eye area makes it easy to cause secondary infection of the eye or recurrence of eye diseases during or after the follow-up operation

Method used

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  • Preoperative corneal irrigation solution, preparation method and application thereof
  • Preoperative corneal irrigation solution, preparation method and application thereof
  • Preoperative corneal irrigation solution, preparation method and application thereof

Examples

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preparation example Construction

[0020] The present invention also provides a kind of preparation method of preoperative corneal washing solution, comprising the following steps:

[0021] The mydriatic agent, the analgesic, the bactericide and the pH regulator are mixed, the pH is adjusted to 6-7.5, and then mixed with the electrolyte balance regulator to obtain a mixture.

[0022] The mixture and activated carbon are mixed according to the mass ratio of 1:0.01-0.03. Activated carbon can remove certain pigments or impurities in the preoperative corneal irrigation fluid, reduce the content of germs or other impurities in the preoperative corneal irrigation fluid, and make it more comfortable to use.

[0023] The mixture was mixed with activated carbon and filtered. Filtration is to pass through activated carbon filter, 0.44μm filter membrane, and 0.22μm filter membrane in order to remove impurities or bacteria with large particle size in activated carbon and preoperative corneal irrigation fluid.

[0024] Th...

Embodiment 1

[0027]This embodiment provides a preoperative corneal irrigation solution (100 g), which is mainly made of various raw materials. The various raw materials include 0.85g electrolyte balance regulator, 0.56g pH regulator, 0.35g bactericide, 0.06g mydriatic and 0.028g analgesic. Among them, 0.85g electrolyte balance regulator includes 0.64g sodium chloride, 0.075g potassium chloride, 0.048g calcium chloride dihydrate and 0.05g magnesium chloride hexahydrate; mydriatic agent is tropicamide; 0.028g analgesic includes 0.018g taurine and 0.012g Glauber's salt; 0.35g bactericide includes 0.3g carboxymethyl chitosan and 0.05g benzalkonium chloride; 0.56gpH regulator includes 0.39 sodium acetate and 0.17g sodium citrate, and the remainder is water.

[0028] This embodiment also provides an application of the preoperative corneal irrigation solution in the preparation of medicines for the preoperative corneal irrigation solution in ophthalmology.

[0029] The present embodiment also p...

Embodiment 2

[0034] This embodiment provides a preoperative corneal irrigation solution (100 g), which is mainly made of various raw materials. The various raw materials include 0.5g electrolyte balance regulator, 0.3g pH regulator, 0.1g bactericide, 0.07g mydriatic and 0.01g analgesic. Among them, 0.5g electrolyte balance regulator includes 0.37g sodium chloride, 0.005g potassium chloride, 0.03g calcium chloride dihydrate and 0.05g magnesium chloride hexahydrate; mydriatic agent is homatropine; 0.01g analgesic includes 0.007g taurine and 0.003g Glauber's salt; 0.1g bactericide includes 0.08g carboxymethyl chitosan and 0.02g benzalkonium chloride; 0.3gpH regulator includes 0.2 sodium acetate and 0.1g sodium citrate, and the remainder is water.

[0035] This embodiment also provides an application of the preoperative corneal irrigation solution in the preparation of medicines for the preoperative corneal irrigation solution in ophthalmology.

[0036] The present embodiment also provides a...

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Abstract

The invention relates to the field of eye-drop preparations and particularly relates to a pre-operation cornea flushing fluid and a preparation method and application of the pre-operation cornea flushing fluid. The pre-operation cornea flushing fluid is mainly prepared from various raw materials by weight: 0.5-1 part of an electrolyte balance regulator, 0.3-0.7 part of a pH regulator, 0.1-0.4 partof a bactericide, 0.06-0.12 part of a mydriatic, and 0.01-0.03 part of a pain killer. The pre-operation cornea flushing fluid can flush the cornea well before the operation, the particulate matter possibly adhered to the surface of the cornea is cleared, a therapist captures the diseased region conveniently, meanwhile, the cornea is sterilized, the pupillary is dilated, the pain is alleviated, the operation effect of the eye operation is improved, the secondary postoperative infection is prevented, and the osmotic pressure and the pH of the flushing fluid are appropriate, so that the irritation of the flushing fluid on the eye is reduced.

Description

technical field [0001] The invention relates to the field of ophthalmic preparations, in particular to a preoperative corneal washing solution, a preparation method and an application thereof. Background technique [0002] At present, eye preparations generally include drops for daily use and drops for surgery, and drops for surgery are more researched on drops during surgery, and less research is done on drops before surgery. At the same time, existing pre-operative drops For eye cleaning, normal saline is generally used to clean the cornea, but the use of normal saline to rinse the eyes has a high osmotic pressure, which is irritating to the eye and cannot effectively disinfect the cornea, which in turn leads to eye damage. Insufficient internal cleaning makes it easy to cause secondary infection of the eye or recurrence of eye diseases during or after the follow-up operation. Contents of the invention [0003] The purpose of the present invention is to provide a preope...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K33/04A61P27/02A61P29/00A61P31/02A61K31/4409A61K31/185A61K31/46A61K31/14A61K31/722
CPCA61K9/0048A61K9/08A61K31/14A61K31/185A61K31/4409A61K31/46A61K31/722A61K33/04A61K47/12A61K2300/00
Inventor 刘程炜付欢吴鸣王超马新娜李心洁
Owner 湖北远大天天明制药有限公司
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