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Pharmaceutical preparation for chronic pelvic inflammatory disease and preparation method thereof

A technology for chronic pelvic inflammatory disease and pharmaceutical preparations, which is applied in the direction of medical formulas, drug combinations, and medical preparations containing active ingredients, and can solve problems such as high cost, many types of raw materials, and unclear mechanism of action

Active Publication Date: 2020-09-01
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Puling Penyankang Granules is a pharmaceutical preparation independently developed by the applicant with a drug batch number. It has a good therapeutic effect on chronic pelvic inflammatory disease. For this product, the applicant has also applied for a patent technology on Puling Penyankang Granules. For example, "2006101525479, a drug for treating chronic pelvic inflammatory disease and its preparation method", which protects Puling Penyankang granules on sale; the later patent "2015103361326, a pharmaceutical preparation of Puling Penyankang for pelvic inflammatory disease and its detection method" has been improved on the basis of the known Puling Penyankang Granules, including 40 parts of Dandelion, 35 parts of Smilax, 35 parts of Bangui, 35 parts of Pueraria, 30 parts of Lily, 30 parts of Cyperus, 30 parts of Radix Paeoniae Rubra, 25 parts of Patrinia, 25 parts of Phellodendron Phellodendri, 25 parts of Draconis japonicus, 25 parts of Cinnamon, 20 parts of Trigonium, 20 parts of Puhuang, 20 parts of Citrus aurantium, 17 parts of Myrrh, 17 parts of Platycodon grandiflorum, 15 parts of Angelica dahurica 10 parts, 10 parts of madder, 10 parts of poria cocos, 10 parts of forsythia, 10 parts of hundred parts, 5 parts of honeysuckle, its effect is better than known medicines, but there are many types of raw materials, unclear mechanism of action, high defects such as cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A pharmaceutical preparation for chronic pelvic inflammatory disease, which is prepared from the following raw materials:

[0035] Smilax 400g, Salvia 200g, Prunella vulgaris 200g, Dandelion 250g, Carnation 2000g, Rhizoma 150g, Eucommia 150g, Panax notoginseng 50g, Chuanxiong 80g.

[0036] The preparation method of described pharmaceutical preparation comprises the steps:

[0037]Step 1): take Danshen, crush it into 200 mesh powder, impregnate it with 1.5 times the weight of 90% (v / v) ethanol for 24 hours, then add 90% (v / v) ethanol solution for percolation, and the flow rate is 1-3ml / min, collect the percolation liquid, obtain the medicinal liquid A after the percolation liquid reclaims ethanol, and the medicinal residue is for subsequent use;

[0038] Step 2): Take Rhizoma Chuanxiong, Eucommia, Panax notoginseng and Carnation, mix and grind them into 200-mesh powder, add 70% (v / v) ethanol 5 times the weight of the crude drug each time for impregnation for 24 hours, ...

Embodiment 2

[0046] Embodiment 2 Zoology experiment

[0047] Establish mouse animal model of pelvic inflammatory disease: Select healthy Kunming strain mice to construct mouse pelvic inflammatory disease model. Inject 4% chloral hydrate intraperitoneally according to 1% of the mouse's body weight, general anesthesia, place the mouse on a fixed table after a few minutes, subtract the abdominal hair, sterilize the skin with 75% ethanol, take sterilized scissors and tweezers, and cut it open The skin and muscle layer of the mouse’s lower abdomen were cut about 1 cm to expose the uterus. A sterile needle was used to puncture the middle of the uterine horn on one side of the uterus for about 5-6 needles. After the completion, the abdomen was closed layer by layer and the abdominal operation area was disinfected.

[0048] Experimental procedure: select the mice of above-mentioned modeling, be divided into blank control group (do not do any processing) at random after 7 days, sham operation group...

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and discloses a pharmaceutical preparation for chronic pelvic inflammation. The pharmaceutical preparation for the chronicpelvic inflammation is prepared from the following raw materials: 400g of rhizoma smilacis glabrae, 200g of radix salviae miltiorrhizae, 200g of spica prunellae, 250g of herba taraxaci, 2000g of semenplantaginis, 150g of rhizoma dioscoreae hypoglaucae, 150g of cortex eucommiae, 50g of radix notoginseng, and 80g of rhizoma chuanxiong. Animal experiments indicate that the pharmaceutical preparationdisclosed by the invention has good effects and smaller toxic and side effects.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a medicine preparation for chronic pelvic inflammatory disease and a preparation method thereof. Background technique [0002] Pelvic inflammatory disease refers to the inflammation of female pelvic reproductive organs, connective tissue around the uterus and pelvic peritoneum. There are two types of clinical manifestations of pelvic inflammatory disease: acute and chronic. The symptoms of chronic pelvic inflammatory disease are lower abdomen swelling, pain and lumbosacral pain, which are often aggravated after fatigue, sexual intercourse and before and after menstruation. For a long time, there may be symptoms of neurasthenia such as lack of energy, general discomfort, and insomnia. The incidence rate of the disease tends to increase. The causes of the disease are complicated, the condition is stubborn, and it is easy to relapse. The symptoms are good and bad, whic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/90A61K36/896A61P15/00
CPCA61K36/236A61K36/258A61K36/288A61K36/46A61K36/536A61K36/537A61K36/68A61K36/8945A61K36/896A61K36/90A61K2236/15A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 林凡儒林祥宇孙永喜付君叶陈仁燕
Owner XIANGYU PHARMA