Preparation method and application of a fluorescent probe for detecting glutamic acid and aluminum ions based on polydopamine quantum dots

A polydopamine quantum and nano fluorescent probe technology, applied in the nano field, can solve the problems of complex synthesis process, low fluorescence quantum yield, etc., and achieve the effects of high quantum yield, simple synthesis process and good sensitivity

Active Publication Date: 2020-03-27
NANJING TECH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These methods have problems such as low fluorescence quantum yield and complicated synthesis process.

Method used

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  • Preparation method and application of a fluorescent probe for detecting glutamic acid and aluminum ions based on polydopamine quantum dots
  • Preparation method and application of a fluorescent probe for detecting glutamic acid and aluminum ions based on polydopamine quantum dots
  • Preparation method and application of a fluorescent probe for detecting glutamic acid and aluminum ions based on polydopamine quantum dots

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Experimental program
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Embodiment 1

[0036] Embodiment 1: At room temperature, take 94.82mg of dopamine hydrochloride and deionized water configuration 10mL mixed solution in a 20mL glass bottle, make the concentration of dopamine hydrochloride in the mixed solution be 50μM and place it in a dark room for three months to form polydopamine quantum dots. The prepared polydopamine quantum dots were sonicated for one hour, freeze-dried, and a certain amount of polydopamine quantum dots were dropped on a silicon wafer, and characterized by TEM; figure 1 .

Embodiment 2

[0037] Embodiment 2: At room temperature, take 94.82mg of dopamine hydrochloride and deionized water configuration 10mL mixed solution in a 20mL glass bottle, make the concentration of dopamine hydrochloride in the mixed solution be 50μM and place it in a dark room for three months to form polydopamine quantum dots. The prepared polydopamine quantum dots were sonicated for one hour, freeze-dried, and a certain amount of polydopamine quantum dots were taken and characterized by AFM; figure 2 .

Embodiment 3

[0038] Embodiment 3: At room temperature, take 94.82mg of dopamine hydrochloride and deionized water configuration 10mL mixed solution in a 20mL glass bottle, make the concentration of dopamine hydrochloride in the mixed solution be 50μM and place it in a dark room for three months to form polydopamine quantum dots. The prepared polydopamine quantum dots were sonicated for one hour, freeze-dried, and a certain amount of polydopamine quantum dots were taken and characterized by XPS; image 3 .

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Abstract

The invention relates to a preparation method and application of a glutamic acid and aluminum ion detecting nanofluorescent probe based on poly dopamine quantum dots and belongs to the technical fieldof nano materials. The method comprises the step that dopamine (DA) is utilized as a unique precursor to synthesize poly dopamine quantum dots (PDADs) under room temperature; thus, a flexible and controllable method for synthesizing high fluorescence quantum yield PDADs is developed, and the formed PDADs can recognize the glutamic acid and the aluminum ions in high flexibility and high selectivity. In addition, the fluorescent probe is successfully applied to determining a content of the glutamic acid in human serum and monitoring a content of the aluminum ions in a water sample. The fluorescent probe disclosed by the invention has the characteristics of better flexibility, chemical stability, biological compatibility, selectivity and the like.

Description

technical field [0001] The invention relates to a preparation method and application of a polydopamine quantum dot-based fluorescent probe for detecting glutamic acid and aluminum ions, and belongs to the field of nanotechnology. Background technique [0002] Polymeric fluorescent nanoparticles are widely used in chemical sensors, fluorescence imaging, drug delivery, and bioanalytical applications because of their low cytotoxicity, simple surface functionalization, and low cost. Polymeric fluorescent nanoparticles are almost composed of conjugated polymers, which possess either a conjugated backbone or an aromatic building block, resulting in strong fluorescence emission. However, conjugated polymers are usually poorly water-soluble, so functional modifications are inevitable for further analytical and biological applications. Therefore, a progressive strategy to facilitate dispersion in water is to prepare non-conjugated polymer nanoparticles. In recent years, many non-co...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): G01N21/64C09K11/06B82Y20/00B82Y40/00
CPCB82Y20/00B82Y40/00C09K11/06C09K2211/1425G01N21/6428G01N2021/6432
Inventor张承武慈乔乔韩林奇刘金华李林黄维
OwnerNANJING TECH UNIV