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Compound camphor and menthol ointment and preparation method thereof

A technology of salicylate and camphor, applied in the field of medicine, can solve the problems of uneven distribution of main drug components, ineffectiveness of creams, easy instability of creams, etc., and achieves improvement of stability and penetration, promotion of stability, and preparation of The method is simple and easy to control the effect

Inactive Publication Date: 2018-05-08
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are the following problems in the camphor-mentha salicyl ester emulsifiable paste of the prior art: 1, the absorption rate is low, causes waste for raw material drug, 2, because this emulsifiable paste is formed by water phase, oily phase and emulsifier, after emulsifiable paste is placed for a long time It is easy to be unstable, and it is easy to cause the cream to lose its effectiveness due to oil-water separation; the main ingredient is unevenly distributed in the cream, making the drug effect unstable

Method used

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  • Compound camphor and menthol ointment and preparation method thereof
  • Compound camphor and menthol ointment and preparation method thereof
  • Compound camphor and menthol ointment and preparation method thereof

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preparation example Construction

[0041] The present invention also provides a kind of preparation method of above-mentioned camphor mint salicyl ester emulsifiable paste, it comprises:

[0042] S1. Stir and mix the water-based auxiliary material, carbomer and water at 20-30r / min to obtain the water phase.

[0043] It is preferably mixed in a water phase tank, and the operation is simple and convenient.

[0044] Specifically, the mixing steps of the aqueous phase are as follows:

[0045]Mix water edetate disodium and ethylparaben first, add carbomer under stirring state, overnight, so that carbomer fully swells and dissolves. After filtering, for example, the filtrate can be transferred to an emulsification tank under reduced pressure, and sorbitol and triethanolamine are added to the filtrate under the condition that the stirring rate is 20-30r / min, and after continuing to stir for 5 minutes, heat to 65-75 ℃.

[0046] Optionally, after heating to 65-75°C, it is mixed with dimethyl sulfoxide and edetate dis...

Embodiment 1

[0056] A kind of camphor mint salicyl ester emulsifiable paste, it is made by following method:

[0057] S1. Mix water-based auxiliary materials, carbomer and water, specifically: first mix disodium ethylenediamine tetraacetate and ethylparaben, add carbomer under stirring state, overnight, filter, add to the filtrate Add sorbitol and triethanolamine under the condition that the stirring rate is 25r / min, continue stirring for 5 minutes, and then heat to 65°C.

[0058] Wherein, the water-based auxiliary materials include disodium edetate, ethylparaben, sorbitol and triethanolamine in a weight ratio of 0.015:0.015:15:1.2 in sequence.

[0059] S2. Mix the oil-based auxiliary materials at 74°C and keep warm for 28 minutes to obtain the oil phase.

[0060] The oil-based excipients include stearic acid, glyceryl stearate and polyethylene glycol stearate, pinpina, stearyl alcohol and cetyl alcohol in a weight ratio of 8:3:3:3:2.

[0061] S3. Methyl salicylate, menthol and camphor w...

Embodiment 2

[0065] A kind of camphor mint salicyl ester emulsifiable paste, it is made by following method:

[0066] S1. Mix water-based auxiliary materials, carbomer and water, specifically: first mix disodium ethylenediamine tetraacetate and ethylparaben, add carbomer under stirring state, overnight, filter, add to the filtrate Add sorbitol and triethanolamine under the condition that the stirring rate is 20r / min, continue stirring for 5 minutes, and then heat to 68°C.

[0067] Among them, the water-based auxiliary materials include disodium edetate, ethylparaben, sorbitol and triethanolamine in a weight ratio of 0.02:0.015:14:1.5 in sequence.

[0068] S2. Mix oil-based auxiliary materials at 76°C and keep warm for 30 minutes to obtain an oil phase.

[0069] The oil-based excipients include stearic acid, glyceryl stearate and macrogol stearate, pinpina, stearyl alcohol and cetyl alcohol in a weight ratio of 7:2:2:2.5:2.5.

[0070] S3. Methyl salicylate, menthol and camphor were mixed ...

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Abstract

The invention relates to a compound camphor and menthol ointment and a preparation method thereof. The compound camphor and menthol ointment is prepared from 9-12 parts by weight of methyl salicylate,9-12 parts by weight of mint camphor, 9-12 parts by weight of camphor, 13.5-17 parts by weight of water-based auxiliary materials, 14.5-18 parts by weight of oil-based auxiliary materials, 0.6-1 partby weight of carbomer, and 136-140 parts by weight of water. The compound camphor and menthol ointment is highly stable, main components are uniformly distributed in the ointment and have stable quality, the skin penetration performance is improved, and the ointment can rapidly relive swelling, stop itching and pain and diminish inflammation. The preparation method of the compound camphor and menthol ointment is easy to control, is suitable for industrial application, and effectively improves the stability and penetration performance.

Description

technical field [0001] The invention relates to the field of medicine, and in particular to a camphor menthyl willow ester cream and a preparation method thereof. Background technique [0002] Camphor-menth salicyl ester cream is used for headache, dizziness, insect bites, mosquito bites, swelling and pain relief. Among them, camphor, menthol, and methyl salicylate are all skin stimulants, which can improve local blood circulation to relieve swelling, and have slight itching, pain relief, and anti-inflammatory effects. When used in combination, they can effectively improve the effect. [0003] There are following problems in the camphor-mentha salicyl ester emulsifiable paste of prior art: 1, absorption rate is relatively low, causes waste for crude drug, 2, because this emulsifiable paste is formed by water phase, oily phase and emulsifier, after emulsifiable paste is placed for a long time It is easy to be unstable, and it is easy to cause the cream to lose its effectiven...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/125A61K31/045A61K31/618A61K9/06A61K47/32A61K47/18A61K47/14A61K47/26A61K47/20A61P29/00A61P17/04
Inventor 杨莉梅勇朱锋罗磊唐攀陈波王凤左娟袁开超
Owner 重庆希尔安药业有限公司
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