Carbasalate calcium sustained release preparation and preparation method thereof

The technology of carbasalate calcium and sustained-release preparation is applied in the field of carbasalate calcium sustained-release preparation and preparation thereof, and can solve the problems of short biological half-life of carbasalate calcium and the like

Inactive Publication Date: 2018-05-11
珠海天凯生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention proposes a sustained-release preparation of carbasalate calcium, which solves the problem that the biological half-life of carbasalate calcium itself is very short, and has long-lasting antipyretic and antipyretic effects

Method used

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  • Carbasalate calcium sustained release preparation and preparation method thereof
  • Carbasalate calcium sustained release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A carbasalate calcium sustained-release preparation, calculated according to weight percentage, comprises the following components:

[0022] Carbasalate calcium 50%, stearic acid 7%, carnauba wax 8% and starch 35%.

[0023] Preparation:

[0024] 1) Carbasalate calcium and starch are added to the blender and mixed for 10 minutes;

[0025] 2) Stearic acid and carnauba wax are heated to 70°C and dissolved completely, then poured into a blender and mixed for 10 minutes;

[0026] 3) Put the granules in a shaker, and shake them with a 30-mesh sieve to make granules.

Embodiment 2

[0028] A carbasalate calcium sustained-release preparation, calculated according to weight percentage, comprises the following components:

[0029] Carbasalate Calcium 40%, Glyceryl Monostearate 45%, Lactose 5% and Talc 10%.

[0030] Preparation:

[0031] 1) Carbasalate calcium, lactose, and talcum powder are added to the blender and mixed for 10 minutes;

[0032] 2) After the glyceryl monostearate is heated to 70°C and completely dissolved, pour it into a blender and mix for 10 minutes;

[0033] 3) Put the granules in a shaker, and shake them with a 30-mesh sieve to make granules.

Embodiment 3

[0035] In vitro release test method:

[0036] According to the first method of dissolution, 900ml of 0.1M hydrochloric acid solution is used as the dissolution medium, and the rotating speed is 50rpm per minute. Operate according to the law. After 1, 2, 4, 6, and 8 hours, take an appropriate amount of the solution, filter it, and take the subsequent filtrate as the supply. Test solution; another carbasalate calcium reference substance was taken, accurately weighed, dissolved in a dissolution medium and quantitatively diluted to make a corresponding concentration, measured absorbance at 276nm according to ultraviolet spectrophotometry, and calculated dissolution by external standard method. Limits shall comply with the requirements in Table 1 below:

[0037] Table 1 Dissolution Requirement Limit Table

[0038] time

scope

1 hour

10～50％

2 hours

25～75％

4 hours

40～80％

6 hours

>75％

[0039] Carbasalate calcium slow-release ...

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PUM

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Abstract

The invention provides a carbasalate calcium sustained release preparation and a preparation method thereof. The carbasalate calcium sustained release preparation comprises the following components byweight percentage: 20-80% of carbasalate calcium, and 10-60% of a sustained release material, wherein the sustained release material is selected from one or more of an erodible skeleton material, aninsoluble skeleton material and an enteric material. The preparation method includes: heating the sustained release material till complete dissolution, then mixing the dissolved sustained material with carbasalate calcium, and putting the mixture into a swing machine for granulation. The sustained release preparation provided by the invention solves the problem of short biological half-life periodof carbasalate calcium itself, and has long-term antipyretic and fever-reducing effects.

Description

technical field [0001] The invention belongs to the technical field of carbasalate calcium preparations, and in particular relates to a carbasalate calcium sustained-release preparation and a preparation method thereof. Background technique [0002] Carbasalate Calcium is a white crystalline powder with a slightly bitter taste and is easily soluble in water. It is a complex of calcium acetylsalicylate and urea. Its metabolic characteristics and pharmacological effects are the same as those of aspirin. It has antipyretic, analgesic, anti-inflammatory and anti-platelet aggregation effects, and can prevent thrombosis caused by various reasons. Oral absorption is rapid, rapid onset, high bioavailability, metabolized by the liver, excreted by the kidneys. [0003] Carbasalate Calcium is the only antipyretic and analgesic drug approved in the world for pigs, chickens, cattle, rabbits and other livestock and poultry animals, and has been included in the European Pharmacopoeia. Ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/222A61K47/12A61K47/44A61K47/14A61K47/10A61K47/46A61K47/38A61K47/32A61P29/00
CPCA61K9/0002A61K9/1611A61K9/1617A61K9/1623A61K9/1635A61K9/1652A61K31/222
Inventor 麦耀权张晓明朱帆
Owner 珠海天凯生物科技有限公司
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