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Girald Daphne Bark total coumarin hydrogel matrix sustained release tablet

A total coumarin and hydrogel technology, which is applied in the field of Zushima total coumarin hydrogel matrix sustained-release tablets, can solve the problems of limited application of Zushima and its extract, short action time, etc. The frequency of taking the medicine, the long-lasting effect, and the effect of improving the curative effect

Inactive Publication Date: 2015-10-14
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition, these preparations account for a large proportion of ancestralin preparations. The existing studies on the chemical components and pharmacological activities of ancestral have shown that it is not only ancestralin that exerts the medicinal effect in ancestral, but also other coumarins. Compounds like these also have certain biological activities, and there may be synergistic effects among these active ingredients. Traditional Chinese medicine treats diseases with holistic, systematic and comprehensive characteristics. The curative effect of traditional Chinese medicine is the result of multi-channel and multi-target synergy , the existing zushima preparations have obvious anti-inflammatory and analgesic effects and quick onset, but the action time is short, and the effect on the acute stage of such diseases is remarkable, while rheumatism and rheumatoid are both chronic diseases, which require long-term medication to consolidate the curative effect. Medications have a mild and long-lasting effect
Therefore, the clinical application of ancestral hemp and its extracts is greatly limited.

Method used

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  • Girald Daphne Bark total coumarin hydrogel matrix sustained release tablet
  • Girald Daphne Bark total coumarin hydrogel matrix sustained release tablet
  • Girald Daphne Bark total coumarin hydrogel matrix sustained release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of Zushima total coumarin hydrogel skeleton sustained-release tablet, calculated by mass percentage, by mixing the following raw material components: Zushima total coumarin 35%, skeleton material 45%, filler 15% (by Microcrystalline cellulose and lactose in a weight ratio of 1:1), binder 2%, lubricant (talc) 3%.

[0030] When preparing, weigh the total coumarin, skeleton material and filler of Zushima, pass through a 100-mesh sieve and mix evenly, add a binder to make a soft material, granulate with a 20-mesh sieve, dry at 60°C for 2 hours, and sieve with a 18-mesh sieve. Granules, add lubricant, mix well, press tablet (pressure is 4, 7, 9kg / cm 2 ) to obtain Zushi Ma total coumarin hydrogel matrix sustained-release tablets.

Embodiment 2

[0032] A kind of Zushi Ma total coumarin hydrogel skeleton sustained-release tablet, calculated by mass percentage, by mixing the following raw material components: Zushi Ma total coumarin 55%, skeleton material 15%, filler 25% (by Microcrystalline cellulose and lactose in a weight ratio of 1:1), binder 4%, lubricant (micropowder silica gel) 1%.

[0033] The preparation method is the same as in Example 1.

Embodiment 3

[0035] A kind of Zushima total coumarin hydrogel skeleton sustained-release tablet, calculated by mass percentage, by mixing the following raw material components: Zushima total coumarin 45%, skeleton material 30%, filler 20% (by Microcrystalline cellulose and lactose in a weight ratio of 1:1), binder 3%, lubricant (magnesium stearate) 2%.

[0036] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a Girald Daphne Bark total coumarin hydrogel matrix sustained release tablet. The Girald Daphne Bark total coumarin hydrogel matrix sustained release tablet is prepared by mixing 35-55 mass% of Girald Daphne Bark total coumarin, 15-45 mass% of a matrix material, 15-25 mass% of a filler, 2-4 mass% of an adhesive and 1-3 mass% of a lubricant. The Girald Daphne Bark total coumarin hydrogel matrix sustained release tablet has the advantages of stable and lasting medicine release, long lasting time, reduction of the administration frequency, and use convenience.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a slow-release tablet of a total coumarin hydrogel matrix. Background technique [0002] Zushi Ma is the dried root bark and stem bark of Daphne giraldii Nitsche. Analgesic effect; clinically used in the treatment of rheumatic arthralgia, headache, stomach pain, low back pain, bruises and other symptoms, widely used in the folk, known as "hitting all over the floor, can not do without the ancestor's hemp". Zushi hemp mainly contains coumarin, flavonoids, lignin and other components, of which coumarin components have significant anti-inflammatory, analgesic, antithrombotic and other effects. [0003] At present, there are Zushima and its extract preparations on the market, including Zushima Tablets, Zushima Injection, Huang Ruixiang Injection, Zushima Joint Pain Relief Cream and other preparations, which are used to treat pain, bruises, rheumatoid arthritis, etc. . Am...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/83A61K47/38A61K47/26A61K9/22A61P29/00A61P7/02
Inventor 石森林王丽丽杨鸽华冯超
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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