Dronedarone hydrochloride self-microemulsion preparation and preparing method thereof

Abstract

The invention discloses a dronedarone hydrochloride self-microemulsion preparation and a preparing method thereof. A liquid self-microemulsion preparation is prepared from dronedarone hydrochloride, an oil phase, an emulsifier and a co-emulsifier, or a solid self-microemulsion preparation is further prepared from the obtained liquid self-microemulsion preparation and an excipient.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a dronedarone hydrochloride self-microemulsion preparation and a preparation method thereof. Background technique [0002] Dronedarone (Dronedarone) is a new anti-arrhythmic drug. It was developed by the French Sanofi-Aventis company and registered in the United States and the European Union. my country was approved for clinical use in July 2006. Arrhythmia often troubles many patients and doctors, especially the clinical application of amiodarone, because it has a good effect on the control of many ventricular premature contractions, atrial fibrillation or atrial flutter, but it has a large amount for a long time. The application of it causes its side effects to cause deficiencies, especially it causes liver, lung, thyroid and cornea. The drug has electrophysiological effects similar to amiodarone (amiodarone), and is an alternative newer drug for the latter because it d...

AI Technical Summary

Problems solved by technology

Arrhythmia often troubles many patients and doctors, especially the clinical application of amiodarone, because it has a good effect on the control of many premature ventricular contractions, atrial fibrillation or atrial flutter, but the long-term The application of it makes its side effects a fly in the ointment, especially it causes liver, lung, thyroid and cornea etc.