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Microcapsules containing shikonin, preparation method and application

A shikonin and microcapsule technology is applied in the field of shikonin-containing microcapsules and its preparation, which can solve problems such as difficult industrialization, complex preparation process, and poor controllability, and achieve improved stability, easy dispersion, and encapsulation. The effect of high sealing rate

Active Publication Date: 2020-11-24
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method needs to prepare graphene / mesoporous silicon nanocomposites first, and also needs to use hyaluronic acid to plug pores, so the preparation process is complicated, the controllability is poor, and the encapsulation efficiency is low, so the industrialization is very difficult.

Method used

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  • Microcapsules containing shikonin, preparation method and application
  • Microcapsules containing shikonin, preparation method and application
  • Microcapsules containing shikonin, preparation method and application

Examples

Experimental program
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Effect test

Embodiment approach

[0048] According to one embodiment of the present invention, comprise following specific steps:

[0049] (1) Mix gelatin aqueous solution, sodium alginate aqueous solution, shikonin-containing sesame oil solution and emulsifier, and heat to 55°C, and then emulsify at 10000rpm for 2min to obtain the first liquid; wherein, the gelatin aqueous solution The mass volume percentage concentration is 1.5% (m / v), the mass volume percentage concentration of described sodium alginate aqueous solution is 1.5% (m / v), the weight of the sodium alginate of the gelatin of gelatin aqueous solution and sodium alginate aqueous solution The ratio is 5:1, and the emulsifier is Tween and Span with a weight ratio of 1:1;

[0050] (2) Disperse the first liquid in water under the action of continuous stirring, and slowly adjust the pH value to 4.0 to 4.2 with an aqueous acetic acid solution with a mass volume percent concentration of 10% (m / v), and continue stirring for 30 minutes, thereby forming a s...

Embodiment 1

[0065] (1) The gelatin aqueous solution that the mass volume percent concentration is 1.5% (m / v), the sodium alginate aqueous solution that the mass volume percent concentration is 1.5% (m / v) and the sesame oil solution containing shikonin are mixed, and the gelatin The weight ratio with sodium alginate is 5:1. Then add Tween and Span with a weight ratio of 1:1 [Tween-Span (1:1)] as an emulsifier, use a water bath to heat to 55 ° C, and then use a high-speed shearing machine to emulsify at 10,000 rpm for 2 minutes to obtain the first a liquid.

[0066] (2) Use an electric stirrer to disperse the first liquid in water under continuous stirring at 150 rpm, and slowly adjust the pH value to 4.0 with an aqueous acetic acid solution with a mass volume percent concentration of 10% (m / v), and continue stirring 30min, thereby forming the second liquid;

[0067] (3) Use an ice bath to cool the second liquid to below 5°C, slowly add tannic acid (concentration: 0.44% (m / v)) as a curing...

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Abstract

The invention discloses a microcapsule containing alkannin and a preparation method and application thereof. The microcapsule comprises a core and a wall; the core is made from alkannin and sesame oil; the wall comprises gelatin and sodium alginate. Alkannin is micro-encapsulated herein, with high efficiency.

Description

technical field [0001] The invention relates to a drug-containing microcapsule, its preparation method and application, in particular to a shikonin-containing microcapsule, its preparation method and application. Background technique [0002] Shikonin is the main medicinal component of comfrey. Shikonin has anti-inflammation, anti-oxidation, promotion of wound healing, detoxification and rash, anti-virus, anti-tumor and other effects. Shikonin has a very significant curative effect in skin topical preparations. However, shikonin is a naphthoquinone compound, which has poor water solubility, is extremely sensitive to pH, is unstable under alkaline conditions, and is easily decomposed when exposed to light. These factors limit the development of new formulations of shikonin. [0003] Shikonin has good fat solubility, and its external preparations are mainly oily, which easily stains clothes. Making shikonin into microcapsules can isolate it from the external environment an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K31/122A61K47/44A61P17/00
CPCA61K9/0014A61K9/5057A61K31/122A61K47/44
Inventor 马群
Owner BEIJING UNIV OF CHINESE MEDICINE