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Pharmaceutical composition, preparation method and use for preventing or treating gouty arthritis

A technology for gouty arthritis and a composition, which is applied in the field of traditional Chinese medicine, can solve the problems of allopurinol being prone to hypersensitivity reactions, limiting clinical application, and hormone level disorders, achieving outstanding pharmacological effects, improving clinical efficacy, and reducing uric acid levels. Effect

Active Publication Date: 2021-03-12
和光中药科技(天津)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, colchicine has side effects such as gastrointestinal tract, kidney and bone marrow suppression; non-steroidal anti-inflammatory drugs have obvious gastrointestinal side effects such as indigestion, bleeding, erosion and ulcers; Disorder, obesity, adverse reactions such as rebound after drug withdrawal; allopurinol is prone to hypersensitivity reactions, etc., which greatly limits its clinical application

Method used

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  • Pharmaceutical composition, preparation method and use for preventing or treating gouty arthritis
  • Pharmaceutical composition, preparation method and use for preventing or treating gouty arthritis
  • Pharmaceutical composition, preparation method and use for preventing or treating gouty arthritis

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Effect test

Embodiment 1

[0034] The preparation of embodiment 1 QTNF extract

[0035] Take 1 kg of medicinal materials of Qinpi, 2 kg of Smilax cocos, and 1 kg of Achyranthes bidentata, and use 70% v / v ethanol whose weight is 10 times the total weight of medicinal materials to reflux extract three times, each time for 2 hours, collect the extract, and recover the solvent under reduced pressure at 60 ° C to a relative Density 1.20, that is, QTNF extract.

Embodiment 2

[0036] The preparation of embodiment 2 QTNF extract

[0037] Take 1kg of medicinal materials of Qinpi, 5kg of Smilax cocos, and 0.5kg of Achyranthes bidentata, and reflux extraction with 50% v / v ethanol whose weight is 8 times the total weight of medicinal materials, for 1 hour each time, collect the extract, and recover the solvent under reduced pressure at 75°C When the relative density is 1.15, the QTNF extract is obtained.

Embodiment 3

[0038] The preparation of embodiment 3 QTNF extract

[0039] Take 1 kg of medicinal materials of Qinpi, 10 kg of Smilax cocos, and 0.1 kg of Achyranthes bidentata, and extract once with 30% v / v ethanol whose weight is 20 times the total weight of the medicinal materials, for 3 hours each time, collect the extract, and recover the solvent under reduced pressure at 65°C When the relative density is 1.10, the QTNF extract is obtained.

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Abstract

The invention provides a pharmaceutical composition for preventing or treating gouty arthritis, which is prepared by extracting 10% v / v-90% v / v ethanol aqueous solution from Qinpi, Smilax smilax and Achyranthes bidentata. The invention also provides the preparation method and application of the pharmaceutical composition, as well as the pharmaceutical preparation containing the pharmaceutical composition and the preparation method thereof. The pharmaceutical composition of the invention has good anti-inflammatory and antibacterial effects, and can effectively prevent or treat gouty arthritis. Although the pharmaceutical composition of the present invention has few raw materials and medicinal flavors, the combined use of the three has better detoxification and synergistic effects. The source of raw materials of the pharmaceutical composition of the invention is easy to obtain, easy to be industrialized, can be made into various dosage forms according to needs, and provides more convenient, more effective and more controllable modern Chinese medicine for clinical practice.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical composition for preventing or treating gouty arthritis, a preparation method and application thereof, and a pharmaceutical preparation containing the pharmaceutical composition and a preparation method thereof. Background technique [0002] Gout is a disease in which urate is deposited in tissues due to the disorder of purine metabolism, which leads to increased blood uric acid level and / or decreased excretion of uric acid. Urate deposition in joints can lead to acute and chronic arthritis, which is called gouty arthritis . [0003] Acute gouty arthritis is an inflammatory response caused by urate sodium salt microcrystals. Its clinical symptoms are joint swelling, unbearable pain, and recurrent attacks. The solubility of uric acid in body fluids is low. At pH=7.4, the highest solubility of uric acid is 380 μmol / L. When the solubility is exceeded, a sup...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/90A61K36/896A61P19/02A61P29/00A61P19/06
CPCA61K36/21A61K36/63A61K36/896A61K36/90A61K2236/333A61K2236/51A61K2300/00
Inventor 田成旺任涛只德广姜溪陈芙蓉岳南郭倩成雅婷
Owner 和光中药科技(天津)有限公司
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