Feed additive capable of promoting health of livestock and poultry intestines and preparation method

A feed additive and intestinal health technology, applied in animal feed, animal husbandry, pharmaceutical formulations, etc., can solve the problems of reducing livestock and poultry feed intake, ineffective dissolution, affecting feed processing, etc., to promote the intestinal tract of livestock and poultry Healthy, not easy to develop drug resistance, and the effect of inhibiting the proliferation of harmful intestinal bacteria in livestock and poultry

Inactive Publication Date: 2018-05-29
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, carvacrol also has many defects that limit its application in feed: ① strong pungent odor not only affects feed processing but also reduces feed intake of livestock and poultry; ② strong volatility makes it easy to volatilize and lose during feed storage Dosage must be increased; 3. carvacrol is more toxic to animals, and the oral median lethal dose to rats is 810mg / kg body weight; 4. carvacrol is a fat-soluble substance, which cannot be effectively dissolved in the intestinal tract of livestock and poultry, affecting its effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment l

[0031] 1) Add water and stir the montmorillonite, together with sodium chloride equivalent to 15% of the weight of the montmorillonite, to make a suspension slurry with a concentration of 10%, sodiumize it at room temperature for 10 hours, wash it with water 5 times, and remake it with water Ore pulp with a concentration of 15%;

[0032] 2) Slowly add cetylpyridinium chloride equivalent to 15% by weight of montmorillonite into the slurry in step 1) under stirring, and continuously stir and react at room temperature for 6 hours;

[0033] 3) Carvacrol equivalent to 10% of the weight of montmorillonite is slowly added to the slurry in step 2) under stirring, and the reaction is continuously stirred at room temperature for 5 hours;

[0034] 4) The reaction solution in step 3) is filtered and dehydrated, and the obtained filter cake is vacuum-dried and pulverized to obtain a feed additive for promoting intestinal health of livestock and poultry.

[0035]The minimum inhibitory conc...

Embodiment 2

[0039] 1) Add montmorillonite, together with sodium chloride equivalent to 5% of the weight of montmorillonite, add water and stir evenly to make a suspension slurry with a concentration of 20%, sodiumize it at room temperature for 15 hours, wash with water 3 times, and remake it with water Ore pulp with a concentration of 40%;

[0040] 2) Slowly add cetylpyridinium chloride equivalent to 10% by weight of montmorillonite into the slurry in step 1) under stirring, and continuously stir and react at room temperature for 3 hours;

[0041] 3) Carvacrol equivalent to 2% of the weight of montmorillonite was slowly added to the slurry in step 2) under stirring, and the reaction was continuously stirred at room temperature for 3 hours;

[0042] 4) The reaction solution in step 3) is centrifuged and dehydrated, and the obtained filter cake is vacuum-dried and pulverized to obtain a feed additive for promoting intestinal health of livestock and poultry.

[0043] Adding 0.15% of the fee...

Embodiment 3

[0046] 1) Add montmorillonite, together with sodium chloride equivalent to 10% of the weight of montmorillonite, add water and stir evenly to make a suspension slurry with a concentration of 15%, sodiumize it at room temperature for 12 hours, wash 5 times with water, and remake it with water Ore pulp with a concentration of 20%;

[0047] 2) Slowly add cetylpyridinium chloride equivalent to 12% by weight of montmorillonite into the slurry in step 1) under stirring, and continuously stir and react at room temperature for 4 hours;

[0048] 3) Carvacrol equivalent to 5% of the weight of montmorillonite was slowly added to the slurry in step 2) under stirring, and the reaction was continuously stirred at room temperature for 4 hours;

[0049] 4) The reaction solution in step 3) is filtered and dehydrated, and the obtained filter cake is vacuum-dried and pulverized to obtain a feed additive for promoting intestinal health of livestock and poultry.

[0050] Adding 0.1% (mass percent...

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Abstract

The invention discloses a feed additive capable of promoting health of livestock and poultry intestines and a preparation method. Montmorillonite modified with cetylpyridinium chloride is used for loading carvacrol. The montmorillonite is modified with the cetylpyridinium chloride, so that the layer spacing / specific surface area and the hydrophobic character of the montmorillonite are improved, and the adsorption rate of the montmorillonite for the carvacrol is greatly increased. The montmorillonite has favorable biocompatibility and gastrointestinal tract mucosa substantivity, has the release control effect on the loaded carvacrol, can effectively exert the effects of resisting bacteria, resisting inflammation, resisting oxidation and the like, and has the synergistic effect and the synergism effect on antibacterial activity. The feed additive has the characteristics that the antibiotic action is high, and bacteria are not liable to cause drug resistance. The proliferation of harmfulbacteria in intestines of livestock and poultry can be effectively restrained, the height of intestinal villus and the intestinal barrier function are increased, secretion of digestive enzymes is facilitated, digestion of feed nutrients is facilitated, health of the intestines of the livestock and poultry is promoted, and the production performance of the livestock and poultry can be improved.

Description

technical field [0001] The invention relates to a feed additive for promoting intestinal health of livestock and poultry and a preparation method thereof. Background technique [0002] Nowadays, more and more unfavorable factors continue to threaten the health of livestock and poultry, leading to the occurrence of diseases. Once the livestock and poultry get sick, it will reduce the production efficiency of the breeder. Therefore, ensuring the health of livestock and poultry is a prerequisite for ensuring efficient production. The intestine is an important part of the animal body. The health of the intestine determines the overall function and productivity of livestock and poultry. Improving the structure and function of the intestine is of great significance to the development of healthy farming. A stable intestinal environment, a complete intestinal structure and a relatively balanced intestinal micro-ecosystem are the basis for animal intestinal health. The intestinal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/28A23K20/22A23K20/132A23K20/111A61K31/44A61K31/05A61K47/02A61P31/04
CPCA23K20/111A23K20/132A23K20/22A23K20/28A61K31/05A61K31/44A61K47/02A61K2300/00
Inventor 胡彩虹章倩晖曹舒婷王春春吴焕焦乐飞
Owner ZHEJIANG UNIV
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