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Calcium removal method of phosphorylcholine calcium chloride

A phosphorylcholine calcium chloride and cation exchange technology, which is applied in the field of calcium removal of phosphorylcholine calcium chloride, can solve the problems of affecting the condensation reaction speed and conversion rate, insufficient calcium ion removal, troublesome removal procedures, etc. , to achieve the effect of easy serialization and automation, realizing serialization and automation, and saving time

Inactive Publication Date: 2018-06-01
ZHONGSHAN BAILING BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main shortcoming of existing method, the one, remove calcium ion thoroughly enough, there will be a certain amount of calcium ion residue, can affect the speed and conversion rate of condensation reaction to a certain extent; It will cause the hydrolysis of chloroglycerin and become glycerol or glycidol. It is troublesome to remove glycerol or glycidol from the reaction system, which will cause certain difficulties for the post-reaction treatment; the third is that the calcium carbonate in the reaction needs to be filtered from the solution. remove
This process takes more time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A method for removing calcium from phosphorylcholine calcium chloride, comprising the following steps:

[0045] A. Dissolving phosphorylcholine calcium chloride in aqueous solution to obtain phosphorylcholine calcium chloride aqueous solution; wherein the mass ratio of water to phosphorylcholine calcium chloride is 3:1.

[0046] B. Use potassium-type D001 cation-exchange resin to fill the cation-exchange resin column; the amount of potassium-type cation-exchange resin is 1 times the theoretical amount.

[0047] C, at -10 DEG C, allow the phosphorylcholine calcium chloride aqueous solution in the step A to flow through the cation exchange resin column in the step B; The linear velocity of the phosphorylcholine calcium chloride aqueous solution in the cation exchange resin column is 4 m / h;

[0048] D. Detect the calcium ion concentration, if it exceeds the predetermined value, repeat step C.

Embodiment 2

[0050] A method for removing calcium from phosphorylcholine calcium chloride, comprising the following steps:

[0051] A, dissolving phosphorylcholine calcium chloride in an aqueous solution to obtain phosphorylcholine calcium chloride aqueous solution; the mass ratio of water to phosphorylcholine calcium chloride is 200:1.

[0052] B. Potassium-type cation-exchange resin is used to fill the cation-exchange resin column; the potassium-type cation-exchange resin is potassium-type D101 cation-exchange resin. The consumption of potassium type cation exchange resin is 100 times of theoretical consumption. Multiple cation exchange resin columns are used in series.

[0053] C, at 100 DEG C, allow the phosphorylcholine calcium chloride aqueous solution in step A to flow through the cation exchange resin column in step B; The linear velocity of described phosphorylcholine calcium chloride aqueous solution in the cation exchange resin column 0.5 m / h.

[0054] D. Detect the calcium i...

Embodiment 3

[0056] A method for removing calcium from phosphorylcholine calcium chloride, comprising the following steps:

[0057] A. Dissolving phosphorylcholine calcium chloride in aqueous solution to obtain phosphorylcholine calcium chloride aqueous solution; wherein the mass ratio of water to phosphorylcholine calcium chloride is 4:1.

[0058] B. Potassium-type cation-exchange resin is used to fill the cation-exchange resin column; the potassium-type cation-exchange resin is potassium-type D113 cation-exchange resin. The consumption of potassium type cation exchange resin is 50 times of theoretical consumption. Multiple cation exchange resin columns are used in series.

[0059] C, at 20 DEG C, allow the phosphorylcholine calcium chloride aqueous solution in step A to flow through the cation exchange resin column in step B; The linear velocity of described phosphorylcholine calcium chloride aqueous solution in the cation exchange resin column to 2 m / h.

[0060] D. Detect the calcium...

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PUM

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Abstract

The invention discloses a calcium removal method of phosphorylcholine calcium chloride. The calcium removal method is characterized by comprising the following steps of A, dissolving phosphorylcholinecalcium chloride into a water solution, so as to obtain a phosphorylcholine calcium chloride water solution; B, charging potassium type cation exchange resin into a cation exchange resin column; C, enabling the phosphorylcholine calcium chloride water solution in step A to flow through the cation exchange resin column in step B at the temperature of -10 to 100 DEG C; D, detecting the concentration of calcium ions; when the concentration exceeds the preset value, repeating the step C. The calcium removal method of phosphorylcholine calcium chloride has the advantages that the defects in the prior art are overcome; the technology is simple, the calcium removal effect is good, and the calcium removal is quick.

Description

technical field [0001] The invention relates to a method for removing calcium from phosphorylcholine calcium chloride. Background technique [0002] Glycerophosphatidylcholine, referred to as GPC, is a member of the phospholipid family. Plays an important role in the health of cell membranes. Glycerophosphatidylcholine is very abundant in breast milk. It repairs damaged brain function, improves brain function in healthy individuals and rejuvenates aging brains. As a health product, it can promote the biosynthesis of acetylcholine and phosphatidylcholine in the brain, improve people's memory and cognitive ability, and can also effectively treat senile dementia diseases such as Alzheimer's disease. anti-aging nutrients". [0003] Since the content of glycerophosphatidylcholine in food is relatively small, it is difficult to extract it directly from natural products. Generally, semi-synthetic or synthetic methods are required to produce glycerophosphatidylcholine. The sem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/09
CPCC07F9/091
Inventor 欧松彭廷春钟可玲
Owner ZHONGSHAN BAILING BIOTECHNOLOGY CO LTD
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