Absorbable transmitting tissue regeneration membrane based on magnesium alloy and preparation method thereof

A technology for guiding tissue regeneration and magnesium alloys, which is applied in the field of bio-regenerative medicine and can solve the problems of small space maintenance ability and weak bone induction ability.

Inactive Publication Date: 2018-06-15
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to make up for the deficiencies of the above-mentioned prior art, the present invention provides a magnesium alloy-based absorbable guiding tissue regeneration membrane and its preparation method to solve the problems of existing absorbable GBR / GTR membranes with low space maintenance ability, weak osteoinductive ability, and degradation Problems such as acid production in the process

Method used

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  • Absorbable transmitting tissue regeneration membrane based on magnesium alloy and preparation method thereof
  • Absorbable transmitting tissue regeneration membrane based on magnesium alloy and preparation method thereof
  • Absorbable transmitting tissue regeneration membrane based on magnesium alloy and preparation method thereof

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Effect test

Embodiment 1

[0077] The magnesium alloy is processed into a dense magnesium alloy structure induction film with a thickness of 0.2mm after solid solution, extrusion, aging and other treatments.

Embodiment 2

[0079] The magnesium alloy is processed into a metal film with a thickness of 0.2 mm after solid solution, extrusion, aging and other treatments. Finally, the micro-drilling equipment is used to uniformly drill holes on the surface of the round rod. Note that the drilling depth is controlled at 0.1 mm, and the hole diameter is 300 μm. After electrochemical polishing, an asymmetric magnesium alloy structure-induced film is prepared.

Embodiment 3

[0081] Magnesium alloys are selected and subjected to heat treatments such as solid solution and aging. Firstly, high-purity magnesium and magnesium alloys are specially drawn to obtain magnesium wires with a diameter of 0.05mm; then the magnesium wires are woven into a mesh to obtain a magnesium wire mesh with a thickness of 0.2mm. Microstructure-induced film of porous magnesium alloy after electrochemical polishing.

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Abstract

The invention belongs to the field of biological regenerative medicine and relates to an absorbable transmitting tissue regeneration membrane based on a magnesium alloy and a preparation method thereof. The absorbable transmitting tissue regeneration membrane solves the problem that the existing absorbable transmitting tissue regeneration membrane has poor space maintaining ability, has a poor acid production and bone induction capacity in degradation and needs second operation for tissue regeneration membrane removal. The absorbable transmitting tissue regeneration membrane can be processed into a compact membrane, an asymmetric membrane or a porous membrane. Through fluorine conversion, calcium and phosphorus deposition, phosphating and magnetron sputtering, the surface is modified and the modified transmitting tissue regeneration membrane has good biocompatibility. Through degradation of released ions, the inhibition of inflammation and induction of bone tissue regeneration are realized and the clinical needs of transmitting tissue regeneration and repair are satisfied.

Description

technical field [0001] The invention belongs to the field of bioregenerative medicine, and relates to a membrane for guiding tissue regeneration and a preparation method thereof. Background technique [0002] Guided bone / tissue regeneration (GBR / GTR) is currently an effective means to promote bone tissue regeneration. GBR / GTR membrane is placed between soft tissue and bone defect to establish a biological barrier and create a relatively closed tissue environment. , prevent fibrous connective tissue cells and epithelial cells that interfere with bone formation and migrate quickly into the defect area, allow precursor osteoblasts with potential growth ability and slow migration speed to preferentially enter the bone defect area, grow preferentially, and protect blood at the same time The clot slows down the pressure of the covering tissue, gathers osteoinductive factors, conducts bone conduction and other functions, and realizes the repair and regeneration of bone tissue in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/08A61L31/14B22F3/11B22F5/00C25D9/12C23C22/34C23C14/35C23C14/06
CPCA61L31/022A61L31/086A61L31/14A61L31/146A61L31/148A61L2400/18A61L2420/02B22F3/1125B22F5/00B22F2998/10C23C14/06C23C14/35C23C22/34C25D9/12B22F1/0003B22F3/02
Inventor 陈晔王滢
Owner ZHEJIANG SCI-TECH UNIV
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