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3D printed vaginal drug delivery device

A vaginal drug delivery and 3D printing technology, applied in the field of medical products, can solve the problem of no vaginal device, achieve good application prospects and market value, save the mold making process, and be convenient to use.

Inactive Publication Date: 2018-06-19
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the preparation of vaginal devices using 3D printing technology

Method used

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  • 3D printed vaginal drug delivery device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1. 3D printed progesterone vaginal device

[0030] 1. Materials

[0031] Progesterone, purchased from Jiangsu Yuanda Xinyi Pharmaceutical Co., Ltd., batch number: 20170216; polyethylene glycol-4000, purchased from Tianjin Tiantai Fine Chemical Co., Ltd., batch number: 19920705; polylactic acid (PLA), model: 2002D, purchased from American NatureWorks company, batch number: 20160924; Polycaprolactone, model: 6800, purchased from American Solvay Company, batch number: 20160722; Tween-80, purchased from Shanghai Dazhong Pharmaceutical Factory, batch number: 2011923; Hot melt extruder, Model: WellzoomB, purchased from Shenzhen Mistar Technology Co., Ltd.; 3D shape design software, AutoCAD 2007; fused deposition 3D printer, model: CF-12410B, purchased from Hong Kong Renaissance Technology Group.

[0032] 2. Method results

[0033] Weigh 1.5g of progesterone and sieve it, stir and mix with 3g of crushed polyethylene glycol-4000, then put it into a beaker, heat and st...

Embodiment 2

[0036] Example 2. 3D printed estradiol vaginal device

[0037] 1. Materials

[0038] Estradiol, purchased from Guangzhou Yangye Biotechnology Co., Ltd., batch number: 20160524; polyethylene glycol-4000, purchased from Tianjin Tiantai Fine Chemical Co., Ltd., batch number: 19920705; polylactic acid (PLA), model: 2002D, purchased From NatureWorks, USA, batch number: 20160924; polycaprolactone, model: 6800, purchased from Solvay, USA, batch number: 20160722; Tween-80, purchased from Shanghai Dazhong Pharmaceutical Factory, batch number: 2011923; hot melt extruder , model: WellzoomB, purchased from Shenzhen Mistar Technology Co., Ltd.; 3D shape design software, AutoCAD 2007; fused deposition 3D printer, model: CF-12410B, purchased from Hong Kong Renaissance Technology Group.

[0039] 2. Method results

[0040] Take 0.6g of estradiol and 2g of polyethylene glycol-4000 in a small beaker and mix evenly with a vortex mixer; stir it with a glass rod in a water bath at 70°C to dissolv...

Embodiment 3

[0043] Example 3. 3D printed oxytetracycline vaginal device

[0044] Oxytetracycline was purchased from Henan Tianfu Chemical Co., Ltd. Other materials are the same as in Example 1.

[0045] Take oxytetracycline 0.5g and polyethylene glycol-4000 2.0g in a small beaker and mix evenly; stir in a 70°C water bath to melt, then pour it on a stainless steel plate and let it spread naturally. After solidification, cut Form into granules with a diameter of about 3 mm, and set aside; take 0.8 g of Tween-8, 13.0 g of polylactic acid, 3.0 g of polycaprolactone and the above solid dispersion, mix them evenly, put them in the hopper of a desktop extruder, and melt them at 180 ° C Blend and extrude to obtain extruded strips, use the obtained extruded strips to print O-shaped, Y-shaped, M-shaped, U-shaped, and twist-shaped oxytetracycline vaginal devices with a fused deposition 3D printer under heating conditions of 180°C .

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Abstract

The invention discloses a 3D printed vaginal drug delivery device. The device is prepared through 3D printing, and polymer, medicine, pore former and surface active agent are included. The shape of the device can be selected from an O-shape, a Y-shape, an M shape, a T shape, a V shape, a U shape, a twisted shape, a triangle shape, an anchor shape, and other special shapes designed according to disease demands and personal characteristics. The device is characterized in that an individualized design is adopted, medicine carrying dosage can be adjusted, using is convenient, and the shape and themedicine carrying dosage can be flexibly changed according to the personal characteristics and demands to achieve personalized treatment.

Description

technical field [0001] The invention relates to the field of medical products, in particular to a 3D printed vaginal drug delivery device. Background technique [0002] In conventional gynecological drug administration or prevention, vaginal rings are often used, mainly including metal rings, plastic rings and silicone rubber rings. Metal rings and plastic rings cannot be loaded with medicine and can only achieve the purpose of contraception through mechanical stimulation. Silicone rubber vaginal rings can be used for contraception or treatment of certain diseases by loading some chemical substances, but their types, materials, drugs and dosages are limited by existing technologies and production lines, and basically remain fixed, and cannot be adjusted according to the needs of disease treatment and patients. Its own characteristics are adjusted in time. [0003] 3D printing technology is an additive manufacturing process that can be constructed by computer-aided design s...

Claims

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Application Information

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IPC IPC(8): A61M31/00B33Y80/00
CPCA61M31/00A61M2210/1475B33Y80/00A61M2210/005
Inventor 金义光付俊辉王忠泽
Owner ACADEMY OF MILITARY MEDICAL SCI
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