Pharmaceutical composition containing cefcapene pivoxil hydrochloride

A technology of cefcapine hydrochloride and a composition, applied in the field of medicine, can solve the problems of increased preparation cost, poor effect, serious adhesion phenomenon and the like

Inactive Publication Date: 2018-06-22
天津双硕医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Wetting agent water or alcohol needs to be added in the process of wet granulation, which is easy to cause gelation and serious caking phenomenon
The effect of powder direct compression is poor, so it is generally necessary to add a large amount of fillers, and the requirements for fillers are high, which greatly increases the preparation cost and the drug dissolution is not good
Dry granulation can avoid the gelation problem of wet granulation, and the obtained granules can be used to prepare tablets, capsules or granules. falling problem

Method used

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  • Pharmaceutical composition containing cefcapene pivoxil hydrochloride
  • Pharmaceutical composition containing cefcapene pivoxil hydrochloride
  • Pharmaceutical composition containing cefcapene pivoxil hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0135] Example 1 Preparation of Cefcapene Pivoxil Hydrochloride Film Coated Tablets (Unit: g)

[0136] prescription:

[0137]

[0138] The preparation process is as follows:

[0139] 1) Take cefcapene pivoxil hydrochloride raw material and smash it through a 200-mesh sieve for use;

[0140] 2) Take the filler mannitol and 50% of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose, sieve, and set aside;

[0141] 3) Take the prescription amount of cefcapene pivoxil hydrochloride, the filler mannitol and 50% of the prescription amount disintegrant low-substituted hydroxypropyl cellulose, mix them uniformly, dry granulation, and granulate to obtain drug-loaded cefcapene pivoxil hydrochloride granules ;

[0142] 4) Take the drug-loaded cefcapene pivoxil hydrochloride granules, the remaining 50% of the prescription amount is the disintegrant low-substituted hydroxypropyl cellulose, the gel inhibitor acesulfame potassium, the glidant colloidal silicon dioxide, t...

Embodiment 2

[0145] Example 2 Preparation of Cefcapene Pivoxil Hydrochloride Hard Capsules (Unit: g)

[0146] prescription:

[0147]

[0148]

[0149] The preparation process is as follows:

[0150] 1) Take cefcapene pivoxil hydrochloride raw material and smash it through a 200-mesh sieve for use;

[0151] 2) Take the filler mannitol and 50% of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose, sieve, and set aside;

[0152] 3) Take the prescription amount of cefcapene pivoxil hydrochloride, the filler mannitol and 50% of the prescription amount disintegrant low-substituted hydroxypropyl cellulose, mix them uniformly, dry granulation, and granulate to obtain drug-loaded cefcapene pivoxil hydrochloride granules ;

[0153] 4) Take the drug-loaded cefcapene pivoxil hydrochloride granules, the remaining 50% of the prescription amount is the disintegrant low-substituted hydroxypropyl cellulose, the gel inhibitor acesulfame potassium, the glidant colloidal silicon dioxide...

Embodiment 3

[0155] Example 3 Preparation of Cefcapene Pivoxil Hydrochloride Granules (Unit: g)

[0156] prescription:

[0157]

[0158] The preparation process is as follows:

[0159] 1) Take cefcapene pivoxil hydrochloride raw material and smash it through a 200-mesh sieve for use;

[0160] 2) Take the filler mannitol and 50% of the prescription amount of the disintegrant low-substituted hydroxypropyl cellulose, sieve, and set aside;

[0161] 3) Take the prescription amount of cefcapene pivoxil hydrochloride, the filler mannitol and 50% of the prescription amount disintegrant low-substituted hydroxypropyl cellulose, mix them uniformly, dry granulation, and granulate to obtain drug-loaded cefcapene pivoxil hydrochloride granules ;

[0162] 4) Take the drug-loaded cefcapene pivoxil hydrochloride granules, the remaining 50% of the prescription amount is the disintegrant low-substituted hydroxypropyl cellulose, the gel inhibitor acesulfame potassium, the glidant colloidal silicon dioxide, the lubrican...

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PUM

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Abstract

The invention discloses a pharmaceutical composition containing cefcapene pivoxil hydrochloride. By adding acesulfame potassium into the pharmaceutical composition to serve as a gelation inhibitor, the phenomenon is effectively inhibited that a solid preparation gelatinizes in an aqueous solution, the dissolving performance of the solid preparation is effectively improved, and therefore the bioavailability is improved. Besides, by utilizing the sweetening property of acesulfame potassium, the bitter taste problem of a granular preparation is solved. Through a dry granulation technology, moisture, high temperature and other adverse factors are avoided, and in combination with a preparation prescription, and the problem is solved that ester bonds, amide bonds, lactam bonds and primary aminegroups in active pharmaceutical ingredient molecules are hydrolyzed or oxidatively degraded. Through experiments, it is proved that the effects of the pharmaceutical composition containing cefcapene pivoxil hydrochloride are good.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to a pharmaceutical composition containing cefcapene pivoxil hydrochloride and a preparation method thereof. Background technique [0002] Infectious diseases are one of the important diseases that threaten human health, and the occurrence of bacterial drug resistance brings great difficulties to clinical anti-infective treatment. Therefore, rational application of anti-infective drugs and continuous development of new anti-infective drugs are one of the important methods to treat bacterial resistance and improve anti-infective effects. [0003] In recent years, the research of antibacterial drugs has made some progress. Cephalosporins are the largest branch of antibiotics. Since the successful development of cephalothin by E. Lilly in the United States in 1964, about 56 cephalosporin varieties including the first to fourth generations have been marketed worldwide for decades...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/546A61K47/22A61P31/04
CPCA61K31/546A61K9/2013A61K9/2054
Inventor 不公告发明人
Owner 天津双硕医药科技有限公司
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