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Hydroxypropyl methyl cellulose hollow capsule with high oxygen isolation rate and preparing method of hydroxypropyl methyl cellulose hollow capsule

A technology of hollow capsules and hydroxypropylmethyl, which is applied in capsule delivery, pharmaceutical formula, powder delivery, etc. It can solve the problems of broken capsule fragments, reduce friability, improve oxygen barrier and toughness, and reduce oxygen oxidation. risk effect

Inactive Publication Date: 2018-06-22
上海祺宇生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although compared with gelatin capsules, hypromellose capsules are less likely to be broken when pierced, but there are still cases of broken capsule fragments, so it is necessary to further improve the toughness of hypromellose capsules to reduce puncture damage Rate

Method used

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  • Hydroxypropyl methyl cellulose hollow capsule with high oxygen isolation rate and preparing method of hydroxypropyl methyl cellulose hollow capsule
  • Hydroxypropyl methyl cellulose hollow capsule with high oxygen isolation rate and preparing method of hydroxypropyl methyl cellulose hollow capsule
  • Hydroxypropyl methyl cellulose hollow capsule with high oxygen isolation rate and preparing method of hydroxypropyl methyl cellulose hollow capsule

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Experimental program
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Effect test

Embodiment 1～20

[0042] According to the raw materials and proportions of the outer surface coating shown in Table 1, and the conditions of plasma treatment, the hypromellose hollow capsules of the present invention are prepared according to the following steps.

[0043] Step 1. Dissolve hydroxypropyl methylcellulose (produced in Lotte Korea, AN6) in water to make an aqueous solution, immerse the 3# hollow capsule mold in the hydroxypropyl methylcellulose solution and dip it in glue, take it out and dry it on the surface of the capsule mold Form a layer of hypromellose film;

[0044] Step 2. Uniformly disperse the raw materials of the outer surface coating in ethanol according to the proportion shown in Table 1 to obtain the outer surface coating mixed solution. Dip the mold containing the cellulose film in step 1 into the outer surface coating mixture, dry to remove ethanol and cool to room temperature.

[0045] Step 3, applying bias plasma treatment according to the conditions shown in Table ...

Embodiment 21

[0051] Hypromellose hollow capsules with the same thickness were prepared by using the raw materials and proportions of the hydroxypropylmethylcellulose and the outer surface coating in Example 20, but without the plasma treatment in step 3 in the example.

Embodiment 22

[0053] Hypromellose hollow capsules with the same thickness were prepared by using the raw materials and proportions of the hydroxypropylmethylcellulose and the outer surface coating in Example 4, but the plasma treatment was carried out in a nitrogen atmosphere.

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Abstract

The invention discloses a hydroxypropyl methyl cellulose hollow capsule. At least one layer of outer surface coating is included on the outer surface of a capsule wall of the capsule and comprises oneor more of glycerin, glyceride, hydrocarbon, polysiloxane or a derivative of the substances. The outer surface coating has very high oxygen isolation and toughness, the oxygen isolation and toughnessof the hydroxypropyl methyl cellulose hollow capsule are greatly improved, the disadvantage that the hydroxypropyl methyl cellulose hollow capsule itself has a poor oxygen isolation effect is avoided, the hydroxypropyl methyl cellulose hollow capsule can be used for filling a reductive substance, and the storing time of the capsule preparation is prolonged; the puncturing breakage rate of the capsule is also lowered, and the capsule is applicable to filling a dry powder inhaling preparation. Meanwhile, the invention further provides a preparing method of the hydroxypropyl methyl cellulose hollow capsule, the oxygen isolation and toughness of the capsule can be further improved, and the capsule is wider in applicability and more widely applied.

Description

technical field [0001] The invention relates to the field of hollow capsules, in particular to a hypromellose hollow capsule with high oxygen barrier rate and a preparation method thereof. Background technique [0002] With the development of the pharmaceutical industry, capsules are developing very rapidly because they can be used for almost any drug, have no peculiar smell, are easy to swallow, easy to digest and absorb, and have no side effects on the body. They are widely used in the fields of food, medicine and health care products. [0003] The capsule is composed of a hollow capsule shell and its contents, and the hollow capsule shell can be divided into a gelatin hollow capsule and a vegetable hollow capsule. The traditional hollow capsule shell is composed of gelatin. Gelatin is partially degraded from collagen in connective tissues such as animal skin, bone, sarcolemma, and muscle. The main component of gelatin is protein, which is easily contaminated by microorgan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/38A61K47/34A61K47/14A61K9/72
CPCA61K9/4816A61K9/0075A61K47/14A61K47/34A61K47/38
Inventor 马雪华张宇
Owner 上海祺宇生物科技有限公司
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