Medicinal composition with neticonazole hydrochloride
A technology of neconazole hydrochloride and its composition, which is applied in the field of preparation of drugs for the treatment of ocular fungal infections, can solve the problems of narrow antibacterial spectrum, large ocular skin irritation, and high effective concentration of drugs, and achieve broad antifungal spectrum and alleviate Pigmentation, the effect of enhancing medication compliance
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Embodiment 1
[0017] Embodiment 1 neconazole hydrochloride cetyl pyridinium chloride eye drops
[0018]
[0019]
[0020] Preparation method: Weigh the prescribed amount of neconazole hydrochloride and cetylpyridinium chloride, stir and mix with propylene glycol to disperse them evenly; add an appropriate amount of water for injection to fully dissolve to obtain a uniform and stable solution; take another benzalkonium bromide, add water After dissolving, add it to the above solution, stir evenly; add water to the full amount, filter, heat and sterilize, and pack it separately.
Embodiment 2
[0021] Embodiment 2 neconazole hydrochloride cetylpyridinium chloride mouthwash
[0022]
[0023] Preparation method: Weigh the prescribed amount of neconazole hydrochloride and cetylpyridinium chloride, stir and mix with propylene glycol to disperse them evenly; add an appropriate amount of water for injection to fully dissolve to obtain a uniform and stable solution; take another benzalkonium bromide, add water After dissolving, add it to the above solution, stir evenly; add water to the full amount, filter, heat and sterilize, and pack it separately.
Embodiment 3
[0024] Embodiment 3 neconazole hydrochloride cetylpyridinium chloride gel
[0025]
[0026] Preparation process: slowly add carbomer to water with about 50% of the prescription amount, stir while adding until a transparent gel matrix is formed, dissolve neconazole hydrochloride and cetylpyridinium chloride in an appropriate amount of water, and then add to the matrix, Stir evenly, add propylene glycol, glycerin, purified water to the full amount, and adjust the pH value to neutral with triethanolamine to obtain the product.
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