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Medicinal composition with neticonazole hydrochloride

A technology of neconazole hydrochloride and its composition, which is applied in the field of preparation of drugs for the treatment of ocular fungal infections, can solve the problems of narrow antibacterial spectrum, large ocular skin irritation, and high effective concentration of drugs, and achieve broad antifungal spectrum and alleviate Pigmentation, the effect of enhancing medication compliance

Active Publication Date: 2018-06-22
YANGTZE RIVER PHARM GRP GUANGZHOU HAIRUI PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent 02117618.3 discloses a kind of fluconazole eye drops for the treatment of fungal infections in ophthalmology, but its disadvantages are that the antibacterial spectrum is narrow, the therapeutically effective concentration of the drug is relatively high, and it is highly irritating to the eye skin
At present, there is no report on the pharmaceutical composition with neconazole hydrochloride and cetylpyridinium chloride as active ingredients and its definite treatment of fungal infections, especially fungal keratitis pathogens

Method used

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  • Medicinal composition with neticonazole hydrochloride
  • Medicinal composition with neticonazole hydrochloride
  • Medicinal composition with neticonazole hydrochloride

Examples

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Effect test

Embodiment 1

[0017] Embodiment 1 neconazole hydrochloride cetyl pyridinium chloride eye drops

[0018]

[0019]

[0020] Preparation method: Weigh the prescribed amount of neconazole hydrochloride and cetylpyridinium chloride, stir and mix with propylene glycol to disperse them evenly; add an appropriate amount of water for injection to fully dissolve to obtain a uniform and stable solution; take another benzalkonium bromide, add water After dissolving, add it to the above solution, stir evenly; add water to the full amount, filter, heat and sterilize, and pack it separately.

Embodiment 2

[0021] Embodiment 2 neconazole hydrochloride cetylpyridinium chloride mouthwash

[0022]

[0023] Preparation method: Weigh the prescribed amount of neconazole hydrochloride and cetylpyridinium chloride, stir and mix with propylene glycol to disperse them evenly; add an appropriate amount of water for injection to fully dissolve to obtain a uniform and stable solution; take another benzalkonium bromide, add water After dissolving, add it to the above solution, stir evenly; add water to the full amount, filter, heat and sterilize, and pack it separately.

Embodiment 3

[0024] Embodiment 3 neconazole hydrochloride cetylpyridinium chloride gel

[0025]

[0026] Preparation process: slowly add carbomer to water with about 50% of the prescription amount, stir while adding until a transparent gel matrix is ​​formed, dissolve neconazole hydrochloride and cetylpyridinium chloride in an appropriate amount of water, and then add to the matrix, Stir evenly, add propylene glycol, glycerin, purified water to the full amount, and adjust the pH value to neutral with triethanolamine to obtain the product.

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Abstract

The invention discloses a medicinal composition with neticonazole hydrochloride. The medicinal composition uses the neticonazole hydrochloride and cetylpyridinium chloride as medicinal active components, wherein the weight ratio of the cetylpyridinium chloride to the neticonazole hydrochloride in the medicinal composition is 1 to (0.1 to 1,000), is preferably 1 to (10 to 100), and is further preferably 1 to (20 to 70). The medicinal composition can be prepared in a suitable medicinal dosage form for administration, which is preferably an eye drop, a cream and a tablet. The medicinal composition is particularly effective for the treatment of fungal keratitis, and not only are the administration dosages of two medicines decreased and is the obvious synergistic effect reflected, but also themedicinal composition has a certain treatment advantage compared with other similar medicines on the market.

Description

technical field [0001] The invention relates to a pharmaceutical composition of neconazole hydrochloride, in particular to a pharmaceutical composition of cetylpyridinium chloride and neconazole hydrochloride and its application in the preparation of medicines for treating ocular fungal infections. Background technique [0002] Fungal keratitis (Fungal keratitis, FK) is a serious blinding eye disease, and its incidence has been increasing year by year in recent years. So far, more than 70 kinds of fungi have been found in the world that can cause corneal infection, and the main pathogenic bacteria are mostly concentrated in Fusarium, Aspergillus and Candida albicans. At present, the clinical treatment of fungal infections, especially ocular fungal keratitis, is mainly based on drug therapy, but there is still a lack of low-toxicity, high-efficiency, and cheap therapeutic drugs, making the treatment a very difficult problem in clinical practice. The combined application of d...

Claims

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Application Information

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IPC IPC(8): A61K31/4425A61K31/4174A61P31/10A61P27/02
CPCA61K31/4174A61K31/4425A61K2300/00
Inventor 施猛任亚东夏春森刘志强朴永吉汪刘恒齐华平
Owner YANGTZE RIVER PHARM GRP GUANGZHOU HAIRUI PHARM CO LTD
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