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Absorbable hemostatic bone wax and preparation method thereof

A technology of bone wax and gelatin, which is applied in medical formula, surgery, drug delivery, etc. It can solve the problems of remaining in the body, non-degradable absorption of bone wax, unfavorable wound healing, etc., and achieve excellent physical sealing function and hemostatic performance, good Plugging effect, the effect of simple process

Active Publication Date: 2021-08-31
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide an absorbable hemostatic bone wax aimed at defects such as non-degradable and absorbable bone wax left in the body which is not conducive to wound healing in the prior art

Method used

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  • Absorbable hemostatic bone wax and preparation method thereof
  • Absorbable hemostatic bone wax and preparation method thereof
  • Absorbable hemostatic bone wax and preparation method thereof

Examples

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Embodiment 1

[0046] An absorbable hemostatic bone wax, wherein the mass ratio of gelatin to poloxamer is 7:3, and the hemostatic bone wax comprises the following preparation steps:

[0047] S1. Take 40g of gelatin and place it in a beaker, add 60g of water, place it in a 50°C oven until the gelatin is completely dissolved, and prepare a gelatin aqueous solution with a mass concentration of 40%;

[0048]S2. Take 1.6 g of water-soluble carbodiimide (EDC) and dissolve it in 10 ml of purified water (the mass of EDC is 4% of the mass of gelatin), add a cross-linking agent while stirring in the aqueous gelatin solution, and carry out cross-linking treatment. The speed of stirring is 1000r / min, and the addition speed of crosslinking agent is 2mL / s;

[0049] S3. placing the cross-linked gelatin in water to fully swell;

[0050] S4. Divide the swollen gelatin in step S3 into small pieces, then pulverize it into micron-sized gelatin particles with an aqueous phase material pulverizer, and place the...

Embodiment 2

[0057] An absorbable hemostatic bone wax, wherein the mass ratio of gelatin to poloxamer is 9:1, and the hemostatic bone wax comprises the following preparation steps:

[0058] S1. Take 20g of gelatin and place it in a beaker, add 80g of water, place it in an oven at 80°C until the gelatin is completely dissolved, and prepare a gelatin aqueous solution with a mass concentration of 20%;

[0059] S2. Take 2 g of water-soluble carbodiimide (EDC) and dissolve it in 10 ml of purified water (the mass of EDC is 10% of the mass of gelatin), add a cross-linking agent while stirring in the aqueous gelatin solution, and carry out cross-linking treatment, wherein the The stirring speed is 1000r / min, and the crosslinking agent is added at a speed of 2mL / s;

[0060] S3. placing the cross-linked gelatin in water to fully swell;

[0061] S4. The gelatin swollen in step S3 is divided into small pieces, and then placed in an aqueous phase material pulverizer to pulverize it into micron-sized g...

Embodiment 3

[0067] An absorbable hemostatic bone wax, wherein the mass ratio of gelatin to poloxamer is 1:1, and the hemostatic bone wax comprises the following preparation steps:

[0068] S1. Take 5g of gelatin and place it in a beaker, add 95g of water, place it in a 40°C oven until the gelatin is completely dissolved, and prepare a gelatin aqueous solution with a mass concentration of 5%;

[0069] S2. Take 0.5 g of water-soluble carbodiimide (EDC) and dissolve it in 10 ml of purified water (the mass of EDC is 10% of the mass of gelatin), add a cross-linking agent while stirring in the aqueous gelatin solution, and carry out cross-linking treatment, wherein the The speed of stirring is 1000r / min, and the addition speed of crosslinking agent is 2mL / s;

[0070] S3. placing the cross-linked gelatin in water to fully swell;

[0071] S4. After swelling in step S3, the gelatin material is completely swollen and divided into small pieces, and placed in a water phase material pulverizer. The p...

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Abstract

The invention provides an absorbable hemostatic bone wax and a preparation method thereof. The hemostatic bone wax is composed of gelatin and poloxamer, wherein the mass ratio of gelatin to poloxamer is 1:1-9:1. The hemostatic bone wax provided by the invention has degradability, excellent physical blocking effect and hemostatic performance. In addition, the preparation method of the hemostatic bone wax of the present invention is obtained by fully swelling the cross-linked gelatin, performing mechanical crushing, freeze-drying and secondary crushing, swelling in a poloxamer solution, and freeze-drying again. The preparation method of the present invention is simple, the prepared hemostatic bone wax has a suitable volume swelling rate and saturated water absorption rate, the degradation time of the hemostatic bone wax is 8 weeks to 50 weeks, and the blasting pressure is not lower than 60mmHg, which has a good plugging effect , and can be widely used in the field of hemostasis in orthopedics.

Description

technical field [0001] The invention relates to the technical field of hemostatic materials, in particular to an absorbable hemostatic bone wax and a preparation method thereof. Background technique [0002] Bone wax is a material that physically blocks the bleeding of capillaries in the bone marrow. It can effectively block the bleeding of spongy bone, and can be used to stop bleeding when the bone oozes in various emergency patients. The specific mechanism of bone wax is as follows: on the one hand, bone wax has a very high absorption effect on liquid during the hemostasis process, and promotes the concentration of platelets by rapidly absorbing the water in the blood on the bleeding wound, thereby enhancing the aggregation speed and aggregation ability of platelets ; On the other hand, the bone wax forms a hydrogel after absorbing water, which can be blocked on the surface of the wound, increasing the effect of hemostasis. In addition, after the bone wax absorbs water an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/10A61L24/06A61L24/00
CPCA61L24/0042A61L24/0094A61L2400/04C08L89/00C08L71/02
Inventor 马骋张馨之邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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