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A preparation method of medical polylactic acid in situ modified calcium phosphate bone cement 3D printing material

A calcium phosphate bone cement and 3D printing technology, applied in the field of 3D printing materials, can solve the problems of difficult internal stress, structural damage of bone tissue, conduction and dissipation, etc.

Active Publication Date: 2021-02-19
ZHONGSHAN POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are still many clinical application problems of CPC, the most fundamental key technical problem is that the mechanical strength and mechanical properties of the bone tissue after CPC curing are not particularly satisfactory.
The root cause is that the bone tissue cured by CPC is brittle and has poor internal flexibility. When subjected to a large external force, the internal stress generated is difficult to dissipate and dissipate quickly, resulting in the bone tissue cured by CPC. Structural damage occurs due to the action of a large external force

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A method for preparing medical polylactic acid in situ modified calcium phosphate bone cement 3D printing material, comprising the following steps:

[0027] Step 1, preparation of organic hectorite: first disperse 100 parts of hectorite in 400 parts of water at 70°C, and simultaneously disperse 20 parts of quaternary ammonium salts in 400 parts of water at 70°C to obtain hot solutions respectively; then The two hot solutions were mixed, heated to 93°C and stirred for 1.5 hours; then washed, filtered, and dried to constant weight at 80°C to obtain organohexonite;

[0028] In the present embodiment, the quaternary ammonium salt is octadecyltrimethylammonium bromide;

[0029] Wherein, the water in step 1 is pure water;

[0030] Step 2. Preparation of organic hectorite modified calcium phosphate powder: add 10 parts of organic hectorite and 80 parts of calcium phosphate powder prepared in step 1 to 400 parts of absolute ethanol, raise the temperature to 65°C and keep it wa...

Embodiment 2

[0035] A method for preparing medical polylactic acid in situ modified calcium phosphate bone cement 3D printing material, comprising the following steps:

[0036] Step 1, preparation of organic hectorite: first disperse 100 parts of hectorite in 300 parts of water at 60°C, and simultaneously disperse 10 parts of quaternary ammonium salt in 300 parts of water at 60°C to obtain hot solutions respectively; then The two hot solutions are mixed, heated to 90°C and stirred for 1 hour; then washed, filtered, and dried to constant weight at 60°C to obtain organohexonite;

[0037] In the present embodiment, the quaternary ammonium salt is octadecyltrimethylammonium chloride;

[0038] Wherein, the water in step 1 is pure water;

[0039] Step 2. Preparation of organic hectorite modified calcium phosphate powder: add 5 parts of organic hectorite and 40 parts of calcium phosphate powder prepared in step 1 to 300 parts of absolute ethanol, heat up to 50°C and keep it warm for 5h, and then...

Embodiment 3

[0044] A method for preparing medical polylactic acid in situ modified calcium phosphate bone cement 3D printing material, comprising the following steps:

[0045] Step 1, preparation of organic hectorite: first disperse 100 parts of hectorite in 500 parts of water at 85°C, and simultaneously disperse 30 parts of quaternary ammonium salts in 500 parts of water at 85°C to obtain hot solutions respectively; then The two hot solutions were mixed, heated to 95°C and stirred for 2 hours; then washed, filtered, and dried to constant weight at 105°C to obtain organohexonite;

[0046] In the present embodiment, the quaternary ammonium salt is octadecyltrimethylammonium chloride;

[0047] Wherein, the water in step 1 is pure water;

[0048] Step 2. Preparation of organic hectorite modified calcium phosphate powder: add 15 parts of organic hectorite and 100 parts of calcium phosphate powder prepared in step 1 to 500 parts of absolute ethanol, raise the temperature to 80°C and keep it w...

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PUM

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Abstract

The invention relates to the technical field of 3D printing materials, in particular to a method for preparing medical polylactic acid in-situ modified calcium phosphate bone cement 3D printing materials. The preparation method of the medical polylactic acid in situ modified calcium phosphate bone cement 3D printing material comprises: step 1, preparing organic hectorite; step 2, preparing organic hectorite modified calcium phosphate powder; step 3, preparing 3D printing material . The method is not only low in cost, but also simple in process. The medical polylactic acid in-situ modified calcium phosphate bone cement 3D printing material prepared by the preparation method of the medical polylactic acid in-situ modified calcium phosphate bone cement 3D printing material has the advantages of excellent mechanical strength, mechanical properties and flexibility. Moreover, the preparation method of the present application has strong practicability, and the industrialization prospect is extremely bright.

Description

technical field [0001] The invention relates to the technical field of 3D printing materials, in particular to a method for preparing medical polylactic acid in-situ modified calcium phosphate bone cement 3D printing materials. Background technique [0002] Globally, the number of patients with bone defects due to aging, trauma, bone diseases and many other reasons is increasing year by year. Therefore, the demand for bone defect repair materials is increasing day by day. The traditional bone repair method is mainly the transplantation of autologous bone and allogeneic bone. However, due to many insurmountable problems such as immune rejection, limited supply source, and the need for secondary surgery, the traditional bone grafting method is gradually reduced. At the same time, the use of artificial bone Bone repair materials are rapidly increasing. In the field of artificial medical bone tissue materials, calcium phosphate cement (Calcium phosphate cement, CPC) with calci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/02A61L27/12A61L27/18A61L27/50A61L27/58
CPCA61L27/025A61L27/12A61L27/18A61L27/50A61L27/58A61L2430/02C08L67/04
Inventor 聂建华
Owner ZHONGSHAN POLYTECHNIC