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Method for preparing glycine by carrying out catalytic oxidation on ethanolamine by using ionic liquid

A technology of ionic liquid and glycine, which is applied in the field of catalysis, can solve the problems of sharp increase of process cost and decrease of catalytic activity, and achieve the effect of good selectivity, less catalyst consumption and not easy to deactivate

Active Publication Date: 2018-06-22
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the copper catalyst or Raney copper catalyst used can convert aminoethanol to amino acids, its catalytic activity is greatly reduced during the catalyst recycling process, resulting in a sharp increase in the cost of the process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Put 10mL of 0.5M monoethanolamine solution in a stirred autoclave, add 0.5g NaOH and 0.1g imidazole-type ionic liquid ([Emim][FeCl 4 ]); sealed autoclave, with O 2 Replace the air in the kettle three times, and then fill it with 0.5Mpa oxygen; put the reaction kettle in the stirring heating controller, set the temperature at 50°C, let it stand until the temperature in the kettle reaches the target temperature, turn on the stirring to start the reaction; after 2 hours of reaction, turn off Stirrer, release the pressure, and transfer the reaction solution to a beaker. Under the real-time monitoring of the pH meter, titrate the reaction solution with sulfuric acid solution until the pH reaches about 6.0. The obtained reaction solution can be recrystallized from methanol to obtain the glycine product. The ionic liquid is dissolved in methanol and can be recycled after being concentrated by suspension evaporation.

[0012] The product is qualitatively and quantitatively d...

Embodiment 2

[0014] 10mL of 0.5M monoethanolamine solution was placed in a stirred autoclave, and 0.5g NaOH and 0.1g quaternary ammonium ionic liquid ([N 2224 ][CuCl 2 ]); sealed autoclave, with O 2 Replace the air in the kettle three times, and then fill it with 0.5Mpa of oxygen; put the reactor in the stirring heating controller, set the temperature at 50°C, let it stand until the temperature in the kettle reaches the target temperature, start the stirring to start the reaction; after 2 hours of reaction, turn off Stirrer, release the pressure, and transfer the reaction solution to a beaker. Under the real-time monitoring of the pH meter, the reaction solution was titrated with hydrochloric acid solution until the pH reached about 6.0. The obtained reaction solution can be recrystallized from ethanol to obtain the glycine product. The ionic liquid is dissolved in ethanol, and can be recycled after being concentrated by suspension evaporation.

[0015] The product is qualitatively and...

Embodiment 3

[0017] 10mL of 0.5M monoethanolamine solution was placed in a stirred autoclave, and 0.5g NaOH and 0.1g quaternary ammonium ionic liquid ([N 2224 ][FeCl 4 ]); sealed autoclave, with O 2 Replace the air in the kettle three times, and then fill it with 0.5Mpa of oxygen; put the reactor in the stirring heating controller, set the temperature at 50°C, let it stand until the temperature in the kettle reaches the target temperature, start the stirring to start the reaction; after 2 hours of reaction, turn off Stirrer, release the pressure, and transfer the reaction solution to a beaker. Under the real-time monitoring of the pH meter, titrate the reaction solution with phosphoric acid solution until the pH reaches about 6.0. The obtained reaction solution can be recrystallized from ethanol to obtain the glycine product. The ionic liquid is dissolved in ethanol, and can be recycled after being concentrated by suspension evaporation.

[0018] The product is qualitatively and quanti...

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PUM

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Abstract

The invention relates to a method for preparing glycine by using an oxidation method and specifically relates to a method for preparing glycine by carrying out a reaction on a monoethanolamine solution and oxygen as reaction raw materials under the actions of an ionic liquid catalyst and alkaline to generate glycinate and further acidifying glycinate. The method has the characteristics such as high raw material conversion rate, few byproducts, high yield, simplicity and convenience in operation and catalyst recycle.

Description

technical field [0001] The invention relates to a method for synthesizing glycine by catalytically oxidizing monoethanolamine with an ionic liquid, belonging to the technical field of catalysis. technical background [0002] Glycine is an important fine chemical intermediate, widely used in pesticides, medicine, food, feed and other fields. In terms of pesticides, glycine can be used to produce new pesticide herbicide glyphosate and plant growth regulator glyphosate; in medicine, glycine can be used in the formulation of various amino acid infusions, aureomycin buffer, L-dopa (L-Dopa ) and intermediates of some important amino acids; in food, it can be used as food additives, beverage bittering agents, food antioxidants and preservatives, etc.; in addition, glycine is used in feed additives, organic solvents, and daily chemical products. It has also been widely used and is a very important class of fine chemicals. [0003] At present, the methods for synthesizing glycine m...

Claims

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Application Information

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IPC IPC(8): C07C227/02C07C229/08
CPCC07C227/02C07C229/08Y02P20/584
Inventor 王慧张锁江孟祥展王耀锋盛贵阳刘龙李增喜
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI